Gene/Proteome Database (LMPD)
Proteins
| Nte1p | |
|---|---|
| Refseq ID | NP_013652 |
| Protein GI | 6323581 |
| UniProt ID | Q04958 |
| mRNA ID | NM_001182418 |
| Length | 1679 |
| RefSeq Status | PROVISIONAL |
| MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTNSFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTKASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFGYAWRYIRASMSLAGLLPPLEENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQVPEFLLHRRNSI | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:SGD | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0004622 | IDA:SGD | F | lysophospholipase activity |
| GO:0034638 | IMP:SGD | P | phosphatidylcholine catabolic process |
| GO:0071071 | IMP:SGD | P | regulation of phospholipid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00564 | Glycerophospholipid metabolism |
| sce00564 | Glycerophospholipid metabolism |
BIOCYC Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. |
| Enzyme Regulation | Positively regulated by SEC14. Inhibited by organophosphorus esters in the order phenyl saligenin phosphate (PSP) > phenyldipentyl phosphinate (PDPP) = diisopropyl fluorophosphate (DFP) > and paraoxon (PXN). {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:15611060}. |
| Function | Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:15611060, ECO:0000269|PubMed:16777854}. |
| Miscellaneous | Present with 521 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity | Belongs to the NTE family. {ECO:0000305}. |
| Similarity | Contains 1 patatin domain. {ECO:0000305}. |
| Similarity | Contains 2 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15044461}; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15044461}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007217 (as displayed in Record Overview)
Identical Sequences to LMP007217 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323581 | EMBL | CAA86716.1 | 1679 | unknown [Saccharomyces cerevisiae] |
| GI:6323581 | GenBank | EDV11449.1 | 1679 | phosphatidylcholine and lysophosphatidylcholine phospholipase [Saccharomyces cerevisiae RM11-1a] |
| GI:6323581 | GenBank | EWG89254.1 | 1679 | Nte1p [Saccharomyces cerevisiae P301] |
| GI:6323581 | gnl | McCuskerlabDuke | 1679 | Nte1p [Saccharomyces cerevisiae YJM993] |
| GI:6323581 | SwissProt | Q04958.1 | 1679 | RecName: Full=Lysophospholipase NTE1; AltName: Full=Intracellular phospholipase B; AltName: Full=Neuropathy target esterase homolog [Saccharomyces cerevisiae S288c] |
| GI:6323581 | Third Party Genbank | DAA09838.1 | 1679 | TPA: Nte1p [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007217 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323581 | DBBJ | GAA25389.1 | 1679 | K7_Nte1p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6323581 | EMBL | CAY81762.1 | 1679 | Nte1p [Saccharomyces cerevisiae EC1118] |
| GI:6323581 | GenBank | EDN64336.1 | 1679 | phosphatidylcholine and lysophosphatidylcholine phospholipase [Saccharomyces cerevisiae YJM789] |
| GI:6323581 | GenBank | EIW08624.1 | 1679 | Nte1p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:6323581 | GenBank | EWG83874.1 | 1679 | Nte1p [Saccharomyces cerevisiae R008] |
| GI:6323581 | GenBank | EWH16580.1 | 1679 | Nte1p [Saccharomyces cerevisiae P283] |