Gene/Proteome Database (LMPD)

LMPD ID
LMP007218
Gene ID
856262
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Taz1p
Gene Symbol
TAZ1
Synonyms
-
Alternate Names
Taz1p
Chromosome
XVI
EC Number
2.3.1.23

Proteins

Taz1p
Refseq ID NP_015466
Protein GI 6325398
UniProt ID Q06510
mRNA ID NM_001184237
Length 381
RefSeq Status PROVISIONAL
MSFRDVLERGDEFLEAYPRRSPLWRFLSYSTSLLTFGVSKLLLFTCYNVKLNGFEKLETALERSKRENRGLMTVMNHMSMVDDPLVWATLPYKLFTSLDNIRWSLGAHNICFQNKFLANFFSLGQVLSTERFGVGPFQGSIDASIRLLSPDDTLDLEWTPHSEVSSSLKKAYSPPIIRSKPSWVHVYPEGFVLQLYPPFENSMRYFKWGITRMILEATKPPIVVPIFATGFEKIASEAVTDSMFRQILPRNFGSEINVTIGDPLNDDLIDRYRKEWTHLVEKYYDPKNPNDLSDELKYGKEAQDLRSRLAAELRAHVAEIRNEVRKLPREDPRFKSPSWWKRFNTTEGKSDPDVKVIGENWAIRRMQKFLPPEGKPKGKDD

Gene Information

Entrez Gene ID
856262
Gene Name
Taz1p
Gene Symbol
TAZ1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031307 IDA:SGD C integral component of mitochondrial outer membrane
GO:0005743 IDA:SGD C mitochondrial inner membrane
GO:0005758 TAS:Reactome C mitochondrial intermembrane space
GO:0005741 IDA:SGD C mitochondrial outer membrane
GO:0005739 IDA:SGD C mitochondrion
GO:0047184 IMP:SGD F 1-acylglycerophosphocholine O-acyltransferase activity
GO:0035965 IMP:SGD P cardiolipin acyl-chain remodeling
GO:0032048 IMP:SGD P cardiolipin metabolic process
GO:0007007 IMP:SGD P inner mitochondrial membrane organization
GO:0042775 IMP:SGD P mitochondrial ATP synthesis coupled electron transport
GO:0008654 IMP:SGD P phospholipid biosynthetic process
GO:0006461 IMP:SGD P protein complex assembly

KEGG Pathway Links

KEGG Pathway ID Description
sce00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7416 phospholipid remodeling (phosphatidylcholine)
TRIGLSYN-PWY triacylglycerol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618125 Glycerophospholipid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase
IPR000872 Tafazzin

UniProt Annotations

Entry Information

Gene Name
Taz1p
Protein Entry
TAZ1_YEAST
UniProt ID
Q06510
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=7 uM for lysophosphatidylcholine;
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
Enzyme Regulation Inhibited by zinc and o-phenanthroline. {ECO:0000269|PubMed:9930410}.
Function Acyltransferase which mediates the conversion of 1-acyl- sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a broad LPC fatty acyl chain substrate specificity utilizing LPC molecules ranging in length from C-10 to C-20. Does not utilize other lysolipids than LPC as acceptor. Also shows acyl-CoA-independent acyltransferase activity. Required for normal phospholipid content of mitochondrial membranes. Involved in the remodeling of the acyl groups of cardiolipin in the mitochondrial inner membrane, which affects the assembly and stability of respiratory chain complex IV and its supercomplex forms. {ECO:0000269|PubMed:14651618, ECO:0000269|PubMed:15588229, ECO:0000269|PubMed:16135531}.
Miscellaneous Present with 1340 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the taffazin family. {ECO:0000305}.
Subcellular Location Mitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Intermembrane side {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007218 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6325398 RefSeq NP_015466 381 Taz1p

Identical Sequences to LMP007218 proteins

Reference Database Accession Length Protein Name
GI:6325398 GenBank EGA80631.1 381 Taz1p [Saccharomyces cerevisiae Lalvin QA23]
GI:6325398 GenBank EGA84402.1 381 Taz1p [Saccharomyces cerevisiae VL3]
GI:6325398 GenBank EIW07246.1 381 Taz1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6325398 GenBank EWG82917.1 381 Taz1p [Saccharomyces cerevisiae R008]
GI:6325398 GenBank EWH15597.1 381 Taz1p [Saccharomyces cerevisiae P283]
GI:6325398 gnl McCuskerlabDuke 381 Taz1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007218 proteins

Reference Database Accession Length Protein Name
GI:6325398 DBBJ GAA27097.1 384 K7_Taz1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6325398 GenBank AAT92758.1 381 YPR140W [Saccharomyces cerevisiae]
GI:6325398 GenBank EDZ68673.1 381 YPR140Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6325398 GenBank EEU08320.1 384 Taz1p [Saccharomyces cerevisiae JAY291]
GI:6325398 GenBank EHN04136.1 381 Taz1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6325398 GenBank EWG88248.1 381 Taz1p [Saccharomyces cerevisiae P301]