LIPID MAPS

LMPD ID

LMP007221

Gene ID

853354

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Gwt1p

Gene Symbol

GWT1

Synonyms

-

Chromosome

X

EC Number

2.3.-.-;

Gwt1p
Refseq ID	NP_012444
Protein GI	37362667
UniProt ID	P47026
mRNA ID	NM_001181524
Length	490
MSTLKQRKEDFVTGLNGGSITEINAVTSIALVTYISWNLLKNSNLMPPGISSVQYIIDFALNWVALLLSITIYASEPYLLNTLILLPCLLAFIYGKFTSSSKPSNPIYNKKKMITQRFQLEKKPYITAYRGGMLILTAIAILAVDFPIFPRRFAKVETWGTSLMDLGVGSFVFSNGIVSSRALLKNLSLKSKPSFLKNAFNALKSGGTLLFLGLLRLFFVKNLEYQEHVTEYGVHWNFFITLSLLPLVLTFIDPVTRMVPRCSIAIFISCIYEWLLLKDDRTLNFLILADRNCFFSANREGIFSFLGYCSIFLWGQNTGFYLLGNKPTLNNLYKPSTQDVVAASKKSSTWDYWTSVTPLSGLCIWSTIFLVISQLVFQYHPYSVSRRFANLPYTLWVITYNLLFLTGYCLTDKIFGNSSEYYKVAECLESINSNGLFLFLLANVSTGLVNMSMVTIDSSPLKSFLVLLAYCSFIAVISVFLYRKRIFIKL

Entrez Gene ID

853354

Gene Name

Gwt1p

Gene Symbol

GWT1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005789	IEA:InterPro	C	endoplasmic reticulum membrane
GO:0016021	IDA:SGD	C	integral component of membrane
GO:0032216	IMP:SGD	F	glucosaminyl-phosphotidylinositol O-acyltransferase activity
GO:0006506	IDA:SGD	P	GPI anchor biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
M00065	GPI-anchor biosynthesis, core oligosaccharide
sce_M00065	GPI-anchor biosynthesis, core oligosaccharide
ko00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce01100	Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618074	Metabolism of proteins
5618284	Post-translational modification: synthesis of GPI-anchored proteins
5618285	Post-translational protein modification
5618283	Synthesis of glycosylphosphatidylinositol (GPI)

InterPro Annotations

Accession	Description
IPR009447	GWT1

Entry Information

Gene Name

Gwt1p

Protein Entry

GWT1_YEAST

UniProt ID

P47026

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins
Function	Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins. {ECO:0000269\|PubMed:12714589, ECO:0000269\|PubMed:12753194}.
Interaction	Q12127:CCW12; NbExp=1; IntAct=EBI-25989, EBI-5303; Q05359:ERP1; NbExp=1; IntAct=EBI-25989, EBI-6581; P54837:ERV25; NbExp=1; IntAct=EBI-25989, EBI-6642; P38694:MSC7; NbExp=1; IntAct=EBI-25989, EBI-24511;
Miscellaneous	Target of the antifungal compound 1-[4- butylbenzyl]isoquinoline that inhibits cell wall localization of GPI-anchored mannoproteins.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Sequence Caution	Sequence=CAA58476.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA89384.1; Type=Erroneous initiation; Evidence= ;
Sequence Caution	Sequence=CAA58476.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA89384.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the PIGW family
Similarity	Belongs to the PIGW family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum membrane ; Multi- pass membrane protein {ECO:0000269\|PubMed:12714589, ECO:0000269\|PubMed:14562095}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:12714589, ECO:0000269\|PubMed:14562095}; Multi- pass membrane protein {ECO:0000269\|PubMed:12714589, ECO:0000269\|PubMed:14562095}.