Gene/Proteome Database (LMPD)
Proteins
| diphosphomevalonate decarboxylase MVD1 | |
|---|---|
| Refseq ID | NP_014441 |
| Protein GI | 6324371 |
| UniProt ID | P32377 |
| mRNA ID | NM_001183220 |
| Length | 396 |
| MTVYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLWLNGEPHSIDNERTQNCLRDLRQLRKEMESKDASLPTLSQWKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSLFGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKACVLVVSDIKKDVSSTQGMQLTVATSELFKERIEHVVPKRFEVMRKAIVEKDFATFAKETMMDSNSFHATCLDSFPPIFYMNDTSKRIISWCHTINQFYGETIVAYTFDAGPNAVLYYLAENESKLFAFIYKLFGSVPGWDKKFTTEQLEAFNHQFESSNFTARELDLELQKDVARVILTQVGSGPQETNESLIDAKTGLPKE | |
Gene Information
Entrez Gene ID
Gene Name
diphosphomevalonate decarboxylase MVD1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IEA:InterPro | C | cytosol |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0004163 | IDA:SGD | F | diphosphomevalonate decarboxylase activity |
| GO:0019287 | IEA:UniProtKB-UniPathway | P | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| GO:0016126 | IMP:SGD | P | sterol biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce01110 | Biosynthesis of secondary metabolites |
| M00095 | C5 isoprenoid biosynthesis, mevalonate pathway |
| sce_M00095 | C5 isoprenoid biosynthesis, mevalonate pathway |
| sce01100 | Metabolic pathways |
| ko00900 | Terpenoid backbone biosynthesis |
| sce00900 | Terpenoid backbone biosynthesis |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-7391 | isoprene biosynthesis II (engineered) |
| PWY-922 | mevalonate pathway |
| PWY-922 | mevalonate pathway I |
| ERGOSTEROL-SYN-PWY | superpathway of ergosterol biosynthesis |
| ERGOSTEROL-SYN-PWY | superpathway of ergosterol biosynthesis I |
| PWY-5910 | superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) |
| PWY-5910 | superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5618350 | Asparagine N-linked glycosylation |
| 5618349 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 5618346 | Cholesterol biosynthesis |
| 5618023 | Metabolism |
| 5618091 | Metabolism of lipids and lipoproteins |
| 5618074 | Metabolism of proteins |
| 5618285 | Post-translational protein modification |
| 5618347 | Synthesis of Dolichyl-phosphate |
| 5618348 | Synthesis of substrates in N-glycan biosythesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR029765 | Diphosphomevalonate decarboxylase |
| IPR005935 | Diphosphomevalonate/phosphomevalonate decarboxylase |
| IPR006204 | GHMP kinase N-terminal domain |
| IPR013750 | GHMP kinase, C-terminal domain |
| IPR020568 | Ribosomal protein S5 domain 2-type fold |
| IPR014721 | Ribosomal protein S5 domain 2-type fold, subgroup |
UniProt Annotations
Entry Information
Gene Name
diphosphomevalonate decarboxylase MVD1
Protein Entry
MVD1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2). |
| Interaction | Self; NbExp=1; IntAct=EBI-6498, EBI-6498; P10592:SSA2; NbExp=1; IntAct=EBI-6498, EBI-8603; |
| Miscellaneous | Present with 13700 molecules/cell in log phase SD medium |
| Miscellaneous | Present with 13700 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3. |
| Similarity | Belongs to the diphosphomevalonate decarboxylase family |
| Similarity | Belongs to the diphosphomevalonate decarboxylase family. {ECO:0000305}. |
| Subunit | Homodimer |
| Subunit | Homodimer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007235 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6324371 | RefSeq | NP_014441 | 396 | diphosphomevalonate decarboxylase MVD1 |
Identical Sequences to LMP007235 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP007235 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|