Gene/Proteome Database (LMPD)

LMPD ID
LMP007244
Gene ID
855680
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Slm2p
Gene Symbol
SLM2
Synonyms
LIT1
Alternate Names
Slm2p
Chromosome
XIV

Proteins

Slm2p
Refseq ID NP_014351
Protein GI 398365255
UniProt ID P53955
mRNA ID NM_001182886
Length 656
RefSeq Status PROVISIONAL
MSYQRNSARASLDLRSQYQQLEGRMRSEHFNPAYQQQQQKGQNIPLSLPSSLAQRNPIPYPIDAVTSDPTIPAQLNVYDHDRQNSIVDAAAGTNTTHSLNSNNIPSSQNNNINNNNINNVGSFTDPSMLTLPKMSLHSHQKQYDSNQNDPRSPLAILIPTSAQPTDVLSARFSAWRNVIRAILVYLSETASIQDEIVRQQLRLSHAVQFPFFSIENQYQPVSNEDKSMQKFFLPLGSGSVQDLPTMLTKYHDNLASLASKSSKELTSEIIPRLEDLRRDLLVKIKEIKALQSDFKNSCNKELQQTKHLMKLFNESLKECKLGTPKSDPFLIKLQLEKQIKRQLVEENYLHEAFDNLQNSGAQLESVIVMEIQNGLTSYARILGKEAQVVFDSVISKLDSTILNKNTNLEWDSFILRNISNFVPPNLPMRRFKEISYSNQNDPFTFEVKSGFLEKRSKFLKSYSRGFYVLTPSFLHEFKTPDKHKFSTPLMSIPLVECTVTEHSKKTKSNSEQGKNKFILRTNSNGLIHRGHNWVFKVDSYDDMIEWFGNIKALSSLPNYDDKCKYVSKVAKLSKEKAKSNENTTESVTPQVTNEQHTRYDDVSSSNFPLNSIPKLDNLTITNTTSSIPETNDSQIQNRVPEFYIENVDSPRKSNQL

Gene Information

Entrez Gene ID
855680
Gene Name
Slm2p
Gene Symbol
SLM2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031932 IPI:SGD C TORC2 complex
GO:0005886 IDA:SGD C plasma membrane
GO:0035091 TAS:SGD F phosphatidylinositol binding
GO:0031929 IPI:SGD P TOR signaling
GO:0030036 IGI:SGD P actin cytoskeleton organization
GO:0051017 IGI:SGD P actin filament bundle assembly
GO:0070941 IGI:SGD P eisosome assembly
GO:0016197 IGI:SGD P endosomal transport
GO:0030950 IPI:SGD P establishment or maintenance of actin cytoskeleton polarity
GO:0001558 IGI:SGD P regulation of cell growth

Domain Information

InterPro Annotations

Accession Description
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
Slm2p
Protein Entry
SLM2_YEAST
UniProt ID
P53955
Species
Yeast (S288c)

Comments

Comment Type Description
Function Together with SLM1, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335}.
Interaction P43603:LSB3; NbExp=2; IntAct=EBI-28706, EBI-22980;
Miscellaneous Present with 2610 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Peripheral membrane protein {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}; Cytoplasmic side {ECO:0000269|PubMed:15023338, ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497}.
Subunit Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5- bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2. {ECO:0000269|PubMed:15372071, ECO:0000269|PubMed:15689497, ECO:0000269|PubMed:16738335}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007244 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398365255 RefSeq NP_014351 656 Slm2p

Identical Sequences to LMP007244 proteins

Reference Database Accession Length Protein Name
GI:398365255 EMBL CAA95915.1 656 unnamed protein product [Saccharomyces cerevisiae]
GI:398365255 GenBank AAT92677.1 656 YNL047C [Saccharomyces cerevisiae]
GI:398365255 GenBank AAV20394.1 656 Sequence 654 from patent US 6753314
GI:398365255 GenBank EIW08045.1 656 Slm2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398365255 SwissProt P53955.1 656 RecName: Full=Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2; AltName: Full=Synthetic lethal with MSS4 protein 2; AltName: Full=TORC2 effector protein SLM2 [Saccharomyces cerevisiae S288c]
GI:398365255 Third Party Genbank DAA10498.1 656 TPA: Slm2p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007244 proteins

Reference Database Accession Length Protein Name
GI:398365255 DBBJ GAA26048.1 656 K7_Slm2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:398365255 EMBL CAY82554.1 656 Slm2p [Saccharomyces cerevisiae EC1118]
GI:398365255 GenBank EWG83791.1 656 Slm2p [Saccharomyces cerevisiae R008]
GI:398365255 GenBank EWG89179.1 656 Slm2p [Saccharomyces cerevisiae P301]
GI:398365255 GenBank EWG93840.1 656 Slm2p [Saccharomyces cerevisiae R103]
GI:398365255 gnl McCuskerlabDuke 656 Slm2p [Saccharomyces cerevisiae YJM993]