Gene/Proteome Database (LMPD)

LMPD ID
LMP007260
Gene ID
855288
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
long-chain fatty acid-CoA ligase FAA4
Gene Symbol
FAA4
Synonyms
-
Chromosome
XIII
EC Number
6.2.1.3

Proteins

long-chain fatty acid-CoA ligase FAA4
Refseq ID NP_013974
Protein GI 6323903
UniProt ID P47912
mRNA ID NM_001182754
Length 694
MTEQYSVAVGEAANEHETAPRRNIRVKDQPLIRPINSSASTLYEFALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDKPIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMSQGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPSDKRQNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHFPKPEDPACIMYTSGSTGTPKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANVKTLTPTSTRNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERNIPCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLIGYGLTEGVANACVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNNQGELLFKGAPICSEYYKNPEETAAAFTDDGWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYADENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIELLCGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVYKENT

Gene Information

Entrez Gene ID
855288
Gene Name
long-chain fatty acid-CoA ligase FAA4
Gene Symbol
FAA4
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005811 IDA:SGD C lipid particle
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:SGD F long-chain fatty acid-CoA ligase activity
GO:0001676 IDA:GOC P long-chain fatty acid metabolic process
GO:0015909 IGI:SGD P long-chain fatty acid transport
GO:0035336 IMP:SGD P long-chain fatty-acyl-CoA metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00086 beta-Oxidation, acyl-CoA synthesis
sce_M00086 beta-Oxidation, acyl-CoA synthesis
ko00061 Fatty acid biosynthesis
sce00061 Fatty acid biosynthesis
ko00071 Fatty acid degradation
sce00071 Fatty acid degradation
ko01212 Fatty acid metabolism
sce01212 Fatty acid metabolism
sce01100 Metabolic pathways
ko04146 Peroxisome
sce04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5143 fatty acid activation
PWY-7288 fatty acid beta-oxidation (peroxisome)
YEAST-FAO-PWY fatty acid oxidation (non-cyclic)

REACTOME Pathway Links

REACTOME Pathway ID Description
5618090 Fatty acid, triacylglycerol, and ketone body metabolism
5618114 Fatty Acyl-CoA Biosynthesis
5618023 Metabolism
5618091 Metabolism of lipids and lipoproteins
5618123 Synthesis of very long-chain fatty acyl-CoAs
5618115 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
long-chain fatty acid-CoA ligase FAA4
Protein Entry
LCF4_YEAST
UniProt ID
P47912
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate.
Miscellaneous Present with 31200 molecules/cell in log phase SD medium
Miscellaneous Present with 31200 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007260 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323903 RefSeq NP_013974 694 long-chain fatty acid-CoA ligase FAA4

Identical Sequences to LMP007260 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007260 proteins

Reference Database Accession Length Protein Name