Gene/Proteome Database (LMPD)

LMPD ID
LMP007263
Gene ID
852815
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Gene Symbol
ALG2
Synonyms
-
Chromosome
VII
EC Number
2.4.1.132

Proteins

GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Refseq ID NP_011450
Protein GI 6321373
UniProt ID P43636
mRNA ID NM_001180930
Length 503
MIEKDKRTIAFIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVKNGQLKVEVYGDFLPTNFLGRFFIVFATIRQLYLVIQLILQKKVNAYQLIIIDQLSTCIPLLHIFSSATLMFYCHFPDQLLAQRAGLLKKIYRLPFDLIEQFSVSAADTVVVNSNFTKNTFHQTFKYLSNDPDVIYPCVDLSTIEIEDIDKKFFKTVFNEGDRFYLSINRFEKKKDVALAIKAFALSEDQINDNVKLVICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKTNNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETIKSYVAGENESSATGWLKPAVPIQWATAIDESRKILQNGSVNFERNGPLRVKKYFSREAMTQSFEENVEKVIWKEKKYYPWEIFGISFSNFILHMAFIKILPNNPWPFLFMATFMVLYFKNYLWGIYWAFVFALSYPYEEI

Gene Information

Entrez Gene ID
852815
Gene Name
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Gene Symbol
ALG2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IC:SGD C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004378 IDA:SGD F GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
GO:0033164 IDA:SGD F glycolipid 6-alpha-mannosyltransferase activity
GO:0097502 IDA:GOC P mannosylation
GO:0006490 IDA:SGD P oligosaccharide-lipid intermediate biosynthetic process
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
sce01100 Metabolic pathways
ko00510 N-Glycan biosynthesis
sce00510 N-Glycan biosynthesis
M00055 N-glycan precursor biosynthesis
sce_M00055 N-glycan precursor biosynthesis
ko00513 Various types of N-glycan biosynthesis
sce00513 Various types of N-glycan biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis
MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618350 Asparagine N-linked glycosylation
5618349 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5618074 Metabolism of proteins
5618285 Post-translational protein modification

Domain Information

InterPro Annotations

Accession Description
IPR027054 ALG2
IPR028098 Glyco_trans_4_N
IPR001296 Glycosyl transferase, family 1

UniProt Annotations

Entry Information

Gene Name
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase
Protein Entry
ALG2_YEAST
UniProt ID
P43636
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta- (1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D- Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol
Catalytic Activity GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta- (1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D- Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}.
Catalytic Activity GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)- D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol
Catalytic Activity GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc- beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)- D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol. {ECO:0000269|PubMed:16878994}.
Function Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate
Function Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate. {ECO:0000269|PubMed:16878994}.
Interaction P16661:ALG1; NbExp=2; IntAct=EBI-2459, EBI-2206309;
Miscellaneous Present with 1840 molecules/cell in log phase SD medium
Miscellaneous Present with 1840 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily
Similarity Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044395}; Multi-pass membrane protein {ECO:0000269|PubMed:15044395}.
Subunit Interacts with ALG1
Subunit Interacts with ALG1. {ECO:0000269|PubMed:15044395}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007263 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6321373 RefSeq NP_011450 503 GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase

Identical Sequences to LMP007263 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007263 proteins

Reference Database Accession Length Protein Name