Gene/Proteome Database (LMPD)

LMPD ID
LMP007264
Gene ID
851543
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
oxysterol-binding protein related protein OSH2
Gene Symbol
OSH2
Synonyms
-
Alternate Names
oxysterol-binding protein related protein OSH2
Chromosome
IV

Proteins

oxysterol-binding protein related protein OSH2
Refseq ID NP_010265
Protein GI 6320185
UniProt ID Q12451
mRNA ID NM_001180078
Length 1283
RefSeq Status PROVISIONAL
MSREDLSIAEDLNQVSKPLLKVKLLEVLGQGDFKHLKALVDNEFQPKDDPSVQQVLNLILHYAVQVAPILLIKEIVAHWVDQVGDEKSSSKSDDGIHLDLNYQDENGNTPLHLAAAQSRSDVISFLLSQKSINDCVKNKAHQQPLDMCKDLNVAQMIQLKRDDYFLETVHSLRAAMNKRDFSKLDSIWKNPRNLNLLDINGIDPETGTTLLYEYSQKKDIEMCQWLLKHGAEATVKDGKGRSPLDLVKNIKLPAKPSNNVTPEIKLKNLLEKNLREQAIVHEDVASSKPPTYKGFLKKWTNFAHGYKLRWFILSGDGNLSYYKDQSHVDRPRGTLKVSTCRLHIDSSEKLNFELLGGITGTTRWRLKGNHPIETTRWVNAIQSAIRFAKDKEILNKKKAVPPSLALKNKSPALISHSKTQGSLPEASQYYQHTLHKEVIQPSSVSLYRRPSNNLSVVSSEIQLNDNLTESGKRFVSKMIENRLDGSKTPVGVHTGSALQRVRSSNTLKSNRSMQSGSGVASPIDKVPNGANLSQSNTTTGSTASLSDNNYIDNFEGDEANSDDEEEDLGINFDRDEEYIKAQYGPYKEKLDMYEQAISIELSSLIELIEQEEPSPEVWLTIKKSLINTSTIFGKLKDLTYKRDKRLVDMVSKQGDVNNVWVQSVKELEMELSNKTERLASIDKERRGLKKILHKKLLESHATAGNKESLENDKEQESDTTASTLGQIAKFISATKEEDEASDADEFYDAAELVDEVTELTEAHPEISTAAAPKHAPPPVPNETDNDSQYVQDEKSKIESNVEKTSQKFEKQNNLVTEDEPKTDQSLKNFKAEDKESQVKEKTKEIASSVIGEKTIVAVTTVQKRKEEYLLKEGSYLGYEDGIRKRLSMDKDDRPKISLWAVLKSMVGKDMTRMTLPVTFNEPTSLLQRVAEDLEYSELLDQAATFEDSTLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQVSHHPPISATWTESPRWDFWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVIGILIGNPQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGEVYNKKKQKVWILGGHWNEAIFAKKVVKDGDLSLEKTRTAASAGNGPTDDGTKFLIWKANDRPEEPFNLTPFAITLNAPQPHLLPWLPPTDTRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAARRKREENNLEYHPQWFVRDTHPITKAKYWRYTGKYWVKRRDHDLKDCGDIF

Gene Information

Entrez Gene ID
851543
Gene Name
oxysterol-binding protein related protein OSH2
Gene Symbol
OSH2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005935 IDA:SGD C cellular bud neck
GO:0032541 IDA:SGD C cortical endoplasmic reticulum
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0005886 IDA:SGD C plasma membrane
GO:0005545 ISS:SGD F 1-phosphatidylinositol binding
GO:0008289 IDA:SGD F lipid binding
GO:0008142 ISS:SGD F oxysterol binding
GO:0015248 IDA:SGD F sterol transporter activity
GO:0035621 IMP:SGD P ER to Golgi ceramide transport
GO:0006897 IGI:SGD P endocytosis
GO:0006887 IGI:SGD P exocytosis
GO:0030011 IGI:SGD P maintenance of cell polarity
GO:0015918 IDA:SGD P sterol transport

Domain Information

InterPro Annotations

Accession Description
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol-binding protein related protein OSH2
Protein Entry
OSH2_YEAST
UniProt ID
Q12451
Species
Yeast (S288c)

Comments

Comment Type Description
Domain The FFAT motif is required for interaction with SCS2 and proper localization of the protein. {ECO:0000269|PubMed:12727870}.
Function Lipid-binding protein involved in maintenance of intracellular sterol distribution and homeostasis. Binds to phosphoinositides. {ECO:0000269|PubMed:15173322}.
Interaction P36006:MYO3; NbExp=3; IntAct=EBI-12621, EBI-11670; Q04439:MYO5; NbExp=6; IntAct=EBI-12621, EBI-11687;
Miscellaneous Present with 1069 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the OSBP family. {ECO:0000305}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11408574, ECO:0000269|PubMed:12727870}; Peripheral membrane protein {ECO:0000269|PubMed:11408574, ECO:0000269|PubMed:12727870}. Note=Cell periphery, enriched in small buds of G1 phase cells and near the bud-neck region of S phase cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP007264 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320185 RefSeq NP_010265 1283 oxysterol-binding protein related protein OSH2

Identical Sequences to LMP007264 proteins

Reference Database Accession Length Protein Name
GI:6320185 EMBL CAA88340.1 1283 homolog of yeast SWH1 protein (X74552) [Saccharomyces cerevisiae]
GI:6320185 EMBL CAA98578.1 1283 unnamed protein product [Saccharomyces cerevisiae]
GI:6320185 GenBank EIW11189.1 1283 Osh2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320185 SwissProt Q12451.1 1283 RecName: Full=Oxysterol-binding protein homolog 2 [Saccharomyces cerevisiae S288c]
GI:6320185 Third Party Genbank DAA11831.1 1283 TPA: oxysterol-binding protein related protein OSH2 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007264 proteins

Reference Database Accession Length Protein Name
GI:6320185 EMBL CAY78489.1 1283 Osh2p [Saccharomyces cerevisiae EC1118]
GI:6320185 GenBank EEU04970.1 1283 Osh2p [Saccharomyces cerevisiae JAY291]
GI:6320185 GenBank EHN07998.1 1283 Osh2p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:6320185 GenBank EWG87047.1 1283 Osh2p [Saccharomyces cerevisiae R008]
GI:6320185 GenBank EWG96972.1 1283 Osh2p [Saccharomyces cerevisiae R103]
GI:6320185 gnl McCuskerlabDuke 1283 Osh2p [Saccharomyces cerevisiae YJM993]