Gene/Proteome Database (LMPD)

LMPD ID
LMP007270
Gene ID
851881
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
inositol monophosphate 1-phosphatase INM2
Gene Symbol
INM2
Synonyms
-
Chromosome
IV
EC Number
3.1.3.25

Proteins

inositol monophosphate 1-phosphatase INM2
Refseq ID NP_010573
Protein GI 398366417
UniProt ID Q05533
mRNA ID NM_001180595
Length 292
MVLTRQVLEEVENTFIELLRSKIGPLVKSHAGTNFCSYDDKANGVDLVTALDKQIESIIKENLTAKYPSFKFIGEETYVKGVTKITNGPTFIVDPIDGTTNFIHGYPYSCTSLGLAEMGKPVVGVVFNPHLNQLFHASKGNGAFLNDQEIKVSKRPLILQKSLIALEGGSERTEGSQGNFDKKMNTYKNLLSESGAFVHGFRSAGSAAMNICYVASGMLDAYWEGGCWAWDVCAGWCILEEAGGIMVGGNCGEWNIPLDRRCYLAIRGGCESMEQKRFAESFWPHVAGELEY

Gene Information

Entrez Gene ID
851881
Gene Name
inositol monophosphate 1-phosphatase INM2
Gene Symbol
INM2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008934 IDA:SGD F inositol monophosphate 1-phosphatase activity
GO:0052832 IEA:UniProtKB-EC F inositol monophosphate 3-phosphatase activity
GO:0052833 IEA:UniProtKB-EC F inositol monophosphate 4-phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0046855 IDA:SGD P inositol phosphate dephosphorylation
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
sce01110 Biosynthesis of secondary metabolites
ko00562 Inositol phosphate metabolism
sce00562 Inositol phosphate metabolism
sce01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
sce04070 Phosphatidylinositol signaling system

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-2301 myo-inositol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618626 Inositol phosphate metabolism
5618023 Metabolism
5618625 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR020550 Inositol monophosphatase, conserved site
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
inositol monophosphate 1-phosphatase INM2
Protein Entry
INM2_YEAST
UniProt ID
Q05533
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.12 mM for inositol 1-phosphate {ECO:0000269|PubMed:10096091}; Vmax=16 umol/min/mg enzyme for inositol 1-phosphate {ECO:0000269|PubMed:10096091};
Biophysicochemical Properties Kinetic parameters: KM=0.12 mM for inositol 1-phosphate ; Vmax=16 umol/min/mg enzyme for inositol 1-phosphate ;
Catalytic Activity Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation Inhibited by Li(+) and Na(+)
Enzyme Regulation Inhibited by Li(+) and Na(+). {ECO:0000269|PubMed:10096091}.
Function Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling
Function Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling. {ECO:0000269|PubMed:10096091, ECO:0000269|PubMed:12593845}.
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
Similarity Belongs to the inositol monophosphatase family
Similarity Belongs to the inositol monophosphatase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007270 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398366417 RefSeq NP_010573 292 inositol monophosphate 1-phosphatase INM2

Identical Sequences to LMP007270 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007270 proteins

Reference Database Accession Length Protein Name