Gene/Proteome Database (LMPD)

LMPD ID
LMP007274
Gene ID
855454
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
1-phosphatidylinositol 4-kinase
Gene Symbol
PIK1
Synonyms
PIK120; PIK41
Alternate Names
1-phosphatidylinositol 4-kinase
Chromosome
XIV
EC Number
2.7.1.67

Proteins

1-phosphatidylinositol 4-kinase
Refseq ID NP_014132
Protein GI 6324062
UniProt ID P39104
mRNA ID NM_001183105
Length 1066
RefSeq Status PROVISIONAL
MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS

Gene Information

Entrez Gene ID
855454
Gene Name
1-phosphatidylinositol 4-kinase
Gene Symbol
PIK1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:SGD C nucleus
GO:0005802 IDA:SGD C trans-Golgi network
GO:0004430 IDA:SGD F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 IEA:InterPro P phosphatidylinositol biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0046854 IDA:SGD P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
sce00562 Inositol phosphate metabolism
sce01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY3O-242 phosphatidylinositol phosphate biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR027003 Phosphatidylinositol 4-kinase
IPR021601 Phosphatidylinositol 4-kinase, Pik1, fungi
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
1-phosphatidylinositol 4-kinase
Protein Entry
PIK1_YEAST
UniProt ID
P39104
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Function Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton.
Interaction Q06389:FRQ1; NbExp=3; IntAct=EBI-13423, EBI-11946;
Miscellaneous Present with 1600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Nucleus.
Subunit Interacts with FRQ1. {ECO:0000269|PubMed:10559922}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007274 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324062 RefSeq NP_014132 1066 1-phosphatidylinositol 4-kinase

Identical Sequences to LMP007274 proteins

Reference Database Accession Length Protein Name
GI:6324062 EMBL CAA63231.1 1066 PIK1 [Saccharomyces cerevisiae]
GI:6324062 EMBL CAA96174.1 1066 PIK1 [Saccharomyces cerevisiae]
GI:6324062 GenBank ABZ28010.1 1066 Sequence 1948 from patent US 7314974
GI:6324062 GenBank EDV12501.1 1066 phosphatidylinositol 4-kinase [Saccharomyces cerevisiae RM11-1a]
GI:6324062 SwissProt P39104.1 1066 RecName: Full=Phosphatidylinositol 4-kinase PIK1; Short=PI4-kinase; Short=PtdIns-4-kinase [Saccharomyces cerevisiae S288c]
GI:6324062 Third Party Genbank DAA10293.1 1066 TPA: 1-phosphatidylinositol 4-kinase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007274 proteins

Reference Database Accession Length Protein Name
GI:6324062 EMBL CAY82345.1 1066 Pik1p [Saccharomyces cerevisiae EC1118]
GI:6324062 GenBank EEU07343.1 1066 Pik1p [Saccharomyces cerevisiae JAY291]
GI:6324062 GenBank EWG89010.1 1066 Pik1p [Saccharomyces cerevisiae P301]
GI:6324062 GenBank EWG93908.1 1066 Pik1p [Saccharomyces cerevisiae R103]
GI:6324062 GenBank EWH16363.1 1066 Pik1p [Saccharomyces cerevisiae P283]
GI:6324062 gnl McCuskerlabDuke 1066 Pik1p [Saccharomyces cerevisiae YJM993]