Gene/Proteome Database (LMPD)

LMPD ID
LMP007281
Gene ID
853384
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Las21p
Gene Symbol
LAS21
Synonyms
GPI7
Alternate Names
Las21p
Chromosome
X
EC Number
2.-.-.-

Proteins

Las21p
Refseq ID NP_012473
Protein GI 6322399
UniProt ID P40367
mRNA ID NM_001181495
Length 830
RefSeq Status PROVISIONAL
MNLKQFTCLSCAQLLAILLFIFAFFPRKIVLTGISKQDPDQDRDLQRDRPFQKLVFVIIDALRSDFLFDSQISHFNNVHQWLNTGEAWGYTSFANPPTVTLPRLKSITTGSTPSFIDLLLNVAQDIDSNDLSEHDSWLQQFIQHNNTIRFMGDDTWLKLFPQQWFDFADPTHSFFVSDFTQVDNNVTRNLPGKLFQEWAQWDVAILHYLGLDHIGHKDGPHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLSPKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDFLQLLPNKLASMKENFMHLWKLSDHHGEVALDDFTAEDIYTKMYTIQETLTKSATNYNYPLLTLAFVGFLIITIIAIYVLLRYSGPDFWQLRVSSLSVLLVSIILGVSTFASSFIEEEHQLWWWIVTAFSAVPLFVYRLNVLIIVRWFIMMACVRSIKFWNNSGQKFIYSNVMSNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHFIVTTILVGLCFTYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKLKVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVFQILESQIFYFFQNIPTASLTSTSKIYFSNLVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNIYVVGILMSVANFAPAIYWSMLPWSINYASIPAQVKLQTFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPKLCYFLGWNFVMGLLNGWLPELALLCALD

Gene Information

Entrez Gene ID
853384
Gene Name
Las21p
Gene Symbol
LAS21
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 IDA:SGD C integral component of endoplasmic reticulum membrane
GO:0005887 IDA:SGD C integral component of plasma membrane
GO:0051377 IMP:SGD F mannose-ethanolamine phosphotransferase activity
GO:0016740 IMP:SGD F transferase activity
GO:0006506 IMP:SGD P GPI anchor biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
sce00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5618284 Post-translational modification: synthesis of GPI-anchored proteins
5618283 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

UniProt Annotations

Entry Information

Gene Name
Las21p
Protein Entry
GPI7_YEAST
UniProt ID
P40367
Species
Yeast (S288c)

Comments

Comment Type Description
Function Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Although not essential, addition of ethanolamine phosphate to the second mannose plays an important role in cell separation via the GPI- based modification of daughter-specific proteins. {ECO:0000269|PubMed:10329735, ECO:0000269|PubMed:14985347, ECO:0000269|PubMed:15452134}.
Miscellaneous Present with 259 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Ptm N-glycosylated. {ECO:0000269|PubMed:10329735}.
Similarity Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10329735, ECO:0000269|PubMed:14562095}; Multi- pass membrane protein {ECO:0000269|PubMed:10329735, ECO:0000269|PubMed:14562095}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007281 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322399 RefSeq NP_012473 830 Las21p

Identical Sequences to LMP007281 proteins

Reference Database Accession Length Protein Name
GI:6322399 GenBank EIW09468.1 830 Las21p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6322399 GenBank AFQ84263.1 830 Sequence 35 from patent US 8252294
GI:6322399 GenBank EWG85059.1 830 Las21p [Saccharomyces cerevisiae R008]
GI:6322399 GenBank EWG95068.1 830 Las21p [Saccharomyces cerevisiae R103]
GI:6322399 GenBank EWH17813.1 830 Las21p [Saccharomyces cerevisiae P283]
GI:6322399 gnl McCuskerlabDuke 830 Las21p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007281 proteins

Reference Database Accession Length Protein Name
GI:6322399 DBBJ GAA24297.1 830 K7_Las21p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6322399 GenBank EDZ71280.1 830 YJL062Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GI:6322399 GenBank EEU06724.1 830 Las21p [Saccharomyces cerevisiae JAY291]
GI:6322399 GenBank EGA58149.1 830 Las21p [Saccharomyces cerevisiae FostersB]
GI:6322399 GenBank EGA61651.1 821 Las21p [Saccharomyces cerevisiae FostersO]
GI:6322399 GenBank EJS43165.1 830 las21p [Saccharomyces arboricola H-6]