LIPID MAPS

LMPD ID

LMP007300

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

lanosterol synthase ERG7

Gene Symbol

ERG7

Synonyms

-

Chromosome

VIII

EC Number

5.4.99.7

lanosterol synthase ERG7
Refseq ID	NP_011939
Protein GI	330443583
UniProt ID	P38604
mRNA ID	NM_001179202
Length	731
MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQPHPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARSTLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYIPVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANSLVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEAFQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKFLCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHMISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVECTDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALIALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALGMYSRAYETHTL

Entrez Gene ID

Gene Name

lanosterol synthase ERG7

Gene Symbol

ERG7

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005783	IEA:UniProtKB-KW	C	endoplasmic reticulum
GO:0005811	IDA:SGD	C	lipid particle
GO:0016020	IEA:UniProtKB-KW	C	membrane
GO:0000250	IMP:SGD	F	lanosterol synthase activity
GO:0006696	IMP:SGD	P	ergosterol biosynthetic process

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
sce01100	Metabolic pathways
ko00100	Steroid biosynthesis
sce00100	Steroid biosynthesis

BIOCYC Pathway ID	Description
PWY-6132	lanosterol biosynthesis
PWY-6132	lanosterol biosynthesis
ERGOSTEROL-SYN-PWY	superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY	superpathway of ergosterol biosynthesis I

REACTOME Pathway ID	Description
5618346	Cholesterol biosynthesis
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins

Accession	Description
IPR001330	Prenyltransferase/squalene oxidase
IPR018333	Squalene cyclase
IPR002365	Terpene synthase, conserved site
IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

Gene Name

lanosterol synthase ERG7

Protein Entry

ERG7_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Biophysicochemical Properties	pH dependence: Optimum pH is 7. {ECO:0000269\|PubMed:1731628}; Temperature dependence: Optimum temperature is 35 degrees Celsius. {ECO:0000269\|PubMed:1731628};
Biophysicochemical Properties	pH dependence: Optimum pH is 7. ; Temperature dependence: Optimum temperature is 35 degrees Celsius. ;
Catalytic Activity	(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
Enzyme Regulation	ERG27 is required for activity
Enzyme Regulation	ERG27 is required for activity. {ECO:0000269\|PubMed:12842197}.
Function	Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
Interaction	Q12452:ERG27; NbExp=4; IntAct=EBI-6572, EBI-38132;
Miscellaneous	Present with 2193 molecules/cell in log phase SD medium
Miscellaneous	Present with 2193 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.
Similarity	Belongs to the terpene cyclase/mutase family
Similarity	Belongs to the terpene cyclase/mutase family. {ECO:0000305}.
Similarity	Contains 3 PFTB repeats
Similarity	Contains 3 PFTB repeats. {ECO:0000305}.
Subcellular Location	Lipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Predominantly in lipid particles.