LIPID MAPS

LMPD ID

LMP007302

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Akr1p

Gene Symbol

AKR1

Synonyms

-

Chromosome

IV

EC Number

2.3.1.225

Akr1p
Refseq ID	NP_010550
Protein GI	6320470
UniProt ID	P39010
mRNA ID	NM_001180572
Length	764
MVNELENVPRASTLTNEEQTVDPSNNDSQEDISLGDSNEITSLASLKAIRSGNEEESGNEQVNHNDEAEEDPLLTRYHTACQRGDLATVKEMIHGKLLEVNNDGDSTEHITGLHWASINNRLSVVDFLVSQGADVNARAGALHATPLHWAARYGYVYIVDFLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSLLWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDGADFFQKTDTGKDCFAIAQEMNTVYSLREALTHSGFDYHGYPIKKWFKKSQHAKLVTFITPFLFLGIAFALFSHINPLFVIIVLFLLAIATNKGLNKFVLPSYGRMGVHNVTLLRSPLLSGVFFGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFYLFGQLVIMDPGCLPEETDHENVRQTISNLLEIGKFDTKNFCIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDVGLKNHKAFIFFITLMESGIFTFLALCLEYFDELEDAHEDTSQKNGKCFILGASDLCSGLIYDRFVFLILLWALLQSIWVASLIFVQAFQICKGMTNTEFNVLMKESKSIGPDGLSFNENFNTTPEGFAPSIDPGEESNDTVLAPVPGSTIRKPRTCFGVCYAVTGMDQWLAVIKETIGIKDSTGHNVYSITSRIPTNYGWKRNVKDFWLTSDINAPLWRRILYPPSGSKALLNGIEVDYFKLYKLPNKDVEQGNDMV

Entrez Gene ID

Gene Name

Akr1p

Gene Symbol

AKR1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005768	IEA:UniProtKB-KW	C	endosome
GO:0005794	IDA:SGD	C	Golgi apparatus
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016020	IDA:SGD	C	membrane
GO:0016409	IDA:SGD	F	palmitoyltransferase activity
GO:0019706	IEA:UniProtKB-EC	F	protein-cysteine S-palmitoyltransferase activity
GO:0008270	IEA:InterPro	F	zinc ion binding
GO:0018345	IDA:SGD	P	protein palmitoylation
GO:0006612	IMP:SGD	P	protein targeting to membrane
GO:0030100	IMP:SGD	P	regulation of endocytosis
GO:0010969	IGI:SGD	P	regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion

Accession	Description
IPR002110	Ankyrin repeat
IPR020683	Ankyrin repeat-containing domain
IPR001594	Zinc finger, DHHC-type, palmitoyltransferase

Gene Name

Akr1p

Protein Entry

AKR1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain	The DHHC domain is required for palmitoyltransferase activity.
Function	Palmitoyltransferase specific for casein kinase 1. Palmitoylates isoforms YCK1 and YCK2 at both C-terminal cysteine residues, which is required for their proper plasma membrane localization. Required for constitutive endocytosis of a-factor receptor STE3 and both constitutive and pheromone-induced endocytosis of alpha-factor receptor STE2. {ECO:0000269\|PubMed:10866691, ECO:0000269\|PubMed:12370247, ECO:0000269\|PubMed:15105419, ECO:0000269\|PubMed:8524293, ECO:0000269\|PubMed:9243510}.
Interaction	P18851:STE4; NbExp=3; IntAct=EBI-2421, EBI-7390; P23291:YCK1; NbExp=3; IntAct=EBI-2421, EBI-4718;
Miscellaneous	Present with 4072 molecules/cell in log phase SD medium
Miscellaneous	Present with 4072 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily
Similarity	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. {ECO:0000305}.
Similarity	Contains 1 DHHC-type zinc finger
Similarity	Contains 1 DHHC-type zinc finger. {ECO:0000255\|PROSITE-ProRule:PRU00067}.
Similarity	Contains 6 ANK repeats. {ECO:0000255\|PROSITE- ProRule:PRU00023}.
Subcellular Location	Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.