Gene/Proteome Database (LMPD)

LMPD ID
LMP007307
Gene ID
854495
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
long-chain fatty acid-CoA ligase FAA1
Gene Symbol
FAA1
Synonyms
-
Alternate Names
long-chain fatty acid-CoA ligase FAA1
Chromosome
XV
EC Number
6.2.1.3

Proteins

long-chain fatty acid-CoA ligase FAA1
Refseq ID NP_014962
Protein GI 398366229
UniProt ID P30624
mRNA ID NM_001183737
Length 700
RefSeq Status PROVISIONAL
MVAQYTVPVGKAANEHETAPRRNYQCREKPLVRPPNTKCSTVYEFVLECFQKNKNSNAMGWRDVKEIHEESKSVMKKVDGKETSVEKKWMYYELSHYHYNSFDQLTDIMHEIGRGLVKIGLKPNDDDKLHLYAATSHKWMKMFLGAQSQGIPVVTAYDTLGEKGLIHSLVQTGSKAIFTDNSLLPSLIKPVQAAQDVKYIIHFDSISSEDRRQSGKIYQSAHDAINRIKEVRPDIKTFSFDDILKLGKESCNEIDVHPPGKDDLCCIMYTSGSTGEPKGVVLKHSNVVAGVGGASLNVLKFVGNTDRVICFLPLAHIFELVFELLSFYWGACIGYATVKTLTSSSVRNCQGDLQEFKPTIMVGVAAVWETVRKGILNQIDNLPFLTKKIFWTAYNTKLNMQRLHIPGGGALGNLVFKKIRTATGGQLRYLLNGGSPISRDAQEFITNLICPMLIGYGLTETCASTTILDPANFELGVAGDLTGCVTVKLVDVEELGYFAKNNQGEVWITGANVTPEYYKNEEETSQALTSDGWFKTGDIGEWEANGHLKIIDRKKNLVKTMNGEYIALEKLESVYRSNEYVANICVYADQSKTKPVGIIVPNHAPLTKLAKKLGIMEQKDSSINIENYLEDAKLIKAVYSDLLKTGKDQGLVGIELLAGIVFFDGEWTPQNGFVTSAQKLKRKDILNAVKDKVDAVYSSS

Gene Information

Entrez Gene ID
854495
Gene Name
long-chain fatty acid-CoA ligase FAA1
Gene Symbol
FAA1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005811 IDA:SGD C lipid particle
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:SGD F long-chain fatty acid-CoA ligase activity
GO:0031956 IDA:SGD F medium-chain fatty acid-CoA ligase activity
GO:0001676 IDA:GOC P long-chain fatty acid metabolic process
GO:0015909 IMP:SGD P long-chain fatty acid transport
GO:0035336 IMP:SGD P long-chain fatty-acyl-CoA metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
sce_M00086 beta-Oxidation, acyl-CoA synthesis
sce00071 Fatty acid degradation
sce04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7288 fatty acid beta-oxidation (peroxisome)

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
long-chain fatty acid-CoA ligase FAA1
Protein Entry
LCF1_YEAST
UniProt ID
P30624
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Temperature dependence: Optimum temperature is 30 degrees Celsius.;
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities.
Miscellaneous Present with 7470 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007307 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
398366229 RefSeq NP_014962 700 long-chain fatty acid-CoA ligase FAA1

Identical Sequences to LMP007307 proteins

Reference Database Accession Length Protein Name
GI:398366229 GenBank EIW07747.1 700 Faa1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:398366229 GenBank AGX56817.1 700 Sequence 13953 from patent US 8541208
GI:398366229 GenBank EWG83382.1 700 Faa1p [Saccharomyces cerevisiae R008]
GI:398366229 GenBank EWG88582.1 700 Faa1p [Saccharomyces cerevisiae P301]
GI:398366229 GenBank EWG93256.1 700 Faa1p [Saccharomyces cerevisiae R103]
GI:398366229 gnl McCuskerlabDuke 700 Faa1p [Saccharomyces cerevisiae YJM993]

Related Sequences to LMP007307 proteins

Reference Database Accession Length Protein Name
GI:398366229 DBBJ GAA26626.1 700 K7_Faa1p [Saccharomyces cerevisiae Kyokai no. 7]
GI:398366229 GenBank EDN63641.1 700 long chain fatty acyl-CoA synthetase [Saccharomyces cerevisiae YJM789]
GI:398366229 GenBank EGA56816.1 700 Faa1p [Saccharomyces cerevisiae FostersB]
GI:398366229 GenBank EGA60546.1 563 Faa1p [Saccharomyces cerevisiae FostersO]
GI:398366229 GenBank EHN00062.1 700 Faa1p [Saccharomyces cerevisiae x Saccharomyces kudriavzevii VIN7]
GI:398366229 GenBank EWH16101.1 700 Faa1p [Saccharomyces cerevisiae P283]