LIPID MAPS

LMPD ID

LMP007315

Gene ID

855618

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

Gene Symbol

INP52

Synonyms

SJL2

Chromosome

XIV

EC Number

3.1.3.-

phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52
Refseq ID	NP_014293
Protein GI	6324224
UniProt ID	P50942
mRNA ID	NM_001182944
Length	1183
MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPKAELNGNGFRRLSNHEIYGFIGLIEIEGLMFIATITGKSKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAPKHPCHELRKLLSNGSFYYSTDFDLTCTLQKRGFTEHSLSFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIMYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFRLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKLPHQQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKFKPDVVVLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQYEEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYRNITFPRSKTIPHHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKEKLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSSCVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERHSTPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPDEISTSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPHYLSVAANKLNTSQEHSIKVSPSNSKSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDPN

Entrez Gene ID

855618

Gene Name

phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

Gene Symbol

INP52

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030479	IDA:SGD	C	actin cortical patch
GO:0005737	IDA:SGD	C	cytoplasm
GO:0043813	IDA:SGD	F	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
GO:0004438	IDA:SGD	F	phosphatidylinositol-3-phosphatase activity
GO:0004439	IDA:SGD	F	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0043812	IDA:SGD	F	phosphatidylinositol-4-phosphate phosphatase activity
GO:0006897	IEA:UniProtKB-KW	P	endocytosis
GO:0036092	IDA:GOC	P	phosphatidylinositol-3-phosphate biosynthetic process
GO:0046856	IDA:SGD	P	phosphatidylinositol dephosphorylation
GO:0015031	IEA:UniProtKB-KW	P	protein transport

KEGG Pathway Links

KEGG Pathway ID	Description
ko00562	Inositol phosphate metabolism
sce00562	Inositol phosphate metabolism
sce01100	Metabolic pathways
ko04070	Phosphatidylinositol signaling system
sce04070	Phosphatidylinositol signaling system

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-6364	D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY3O-242	phosphatidylinositol phosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618626	Inositol phosphate metabolism
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins
5618126	Phospholipid metabolism
5618611	PI Metabolism
5618625	Synthesis of IP2, IP, and Ins in the cytosol
5618629	Synthesis of IP3 and IP4 in the cytosol
5618610	Synthesis of PIPs at the plasma membrane

InterPro Annotations

Accession	Description
IPR005135	Endonuclease/exonuclease/phosphatase
IPR000300	Inositol polyphosphate-related phosphatase
IPR002013	SAC domain

Entry Information

Gene Name

phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

Protein Entry

INP52_YEAST

UniProt ID

P50942

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Domain	The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)
Domain	The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000269\|PubMed:10224048}.
Function	Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Specifically functions within the early endocytic pathway and actin organization. {ECO:0000269\|PubMed:10224048, ECO:0000269\|PubMed:10625610, ECO:0000269\|PubMed:10962003, ECO:0000269\|PubMed:11094088, ECO:0000269\|PubMed:11311145, ECO:0000269\|PubMed:15169871, ECO:0000269\|PubMed:15691741, ECO:0000269\|PubMed:15798181, ECO:0000269\|PubMed:16406366, ECO:0000269\|PubMed:17452534, ECO:0000269\|PubMed:9265642, ECO:0000269\|PubMed:9560389, ECO:0000269\|PubMed:9788876}.
Interaction	P15891:ABP1; NbExp=2; IntAct=EBI-28834, EBI-2036; Q06604:BSP1; NbExp=4; IntAct=EBI-28834, EBI-37047; P32790:SLA1; NbExp=3; IntAct=EBI-28834, EBI-17313;
Similarity	Belongs to the synaptojanin family
Similarity	Belongs to the synaptojanin family. {ECO:0000305}.
Similarity	Contains 1 SAC domain. {ECO:0000255\|PROSITE- ProRule:PRU00183}.
Similarity	In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family
Similarity	In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}.
Subcellular Location	Cytoplasm, cytoskeleton, actin patch {ECO:0000269\|PubMed:11094088, ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:15798181, ECO:0000269\|PubMed:16406366}.
Subunit	Interacts with ABP1 and BSP1
Subunit	Interacts with ABP1 and BSP1. {ECO:0000269\|PubMed:12606027, ECO:0000269\|PubMed:15798181}.