LIPID MAPS

LMPD ID

LMP007323

Gene ID

854253

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Tcb1p

Gene Symbol

TCB1

Synonyms

-

Chromosome

XV

Tcb1p
Refseq ID	NP_014729
Protein GI	6324660
UniProt ID	Q12466
mRNA ID	NM_001183505
Length	1186
MAKEDTGVTAPKKPETAQVANINGIDKLEPPKTKEETESSKSVSSEKAAHASDESFKRSIHEASYVGWKQIGGWEDKDELTLDDELMDMTRETFLDNIIPDSLYGDWYHSVAIFFIGGVASFALGHYKFSMGSAFFVIVITSLLYRTSAKKYRGSIRELVQKEFTVQKVENDYESLEWLNAFLDKYWPILEPSVSQLIVQQANEQMATNEAIPKFITQLWIDELTLGVKPPRVDLVKTFQNTASDVVVMDWGISFTPHDLCDMSAKQVRNYVNELAVVKAKIFGITIPVSVSDIAFKAHARVKFKLMTPFPHVETVNIQLLKVPDFDFVATLFGRSIFNWEILAIPGLMTLIQKMAKKYMGPILLPPFSLQLNIPQLLSGSNLSIGILEITVKNAKGLKRTSSILNESIDPYLSFEFNDISIAKTRTVRDTLNPVWDETLYVLLNSFTDPLTISVYDKRAKLKDKVLGRIQYNLNTLHDKTTQRNLKAQFLRNSKPVGELTFDLRFFPTLEEKKLPDGSVEELPDLNTGIAKVVVEEGSRFAEEEQKVTAYVEVYLNAKLVLTTGKATDTGTLKWNSDYEAVIADRRKTRYKFVVKDGKGEEIGSTIQTLNDLIDRSQVNKNLIPLKNQKGDIKITTYWRPVRLEIGSNSVAYTPPIGAIRVFIEKANDLRNLEKFGTIDPYCKVLVNGLSKGRTDFKSQTLNPVWNQVIYVAVTSPNQRITLQCMDVETVNKDRSLGEFNVNVQDLFKKDENDKYEETIDEKAKVGRLVMPKKKPKGTITYYTSFYPALPVLTLEEIQDLDKVNKKKKALELRKSAIDEKKISKEDKAKFDQEWNEVKELEDMYSNRQKLDLPELLQYNQGVLAVTVLNGELPDSGLYVQAFFDDNGHPRFVSPRIPSRIVKNGWSGDVIIKELDKSITTFRVAKNKNYNRVEKCVCEVELPTQELVKNCYYKPSILHLSGEGSAKLMLQISWFPIDTKQLPANDLITNSGDLTIMSRSAENLIASDLNGYSDPYLKYYINNEEDCAYKTKVVKKTLNPKWNDEGTIQINNRLNDVLRIKVMDWDSTSADDTIGTAEIPLNKVKVEGTTELDVPVEGLENAGQDGGMLHLAFSFKPRYTISVSKREKKVGDIASKGLGTGLKAGTTVIGGGVGAIGKIKKGVFGGLGSLTNHKKNHEMGEEETKF

Entrez Gene ID

854253

Gene Name

Tcb1p

Gene Symbol

TCB1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0032541	IDA:SGD	C	cortical endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005886	IEA:UniProtKB-KW	C	plasma membrane
GO:0005544	IEA:UniProtKB-KW	F	calcium-dependent phospholipid binding
GO:0008289	IDA:SGD	F	lipid binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0090158	IGI:SGD	P	endoplasmic reticulum membrane organization
GO:0060304	IGI:SGD	P	regulation of phosphatidylinositol dephosphorylation

InterPro Annotations

Accession	Description
IPR000008	C2 domain
IPR017147	Tricalbin

Entry Information

Gene Name

Tcb1p

Protein Entry

TCB1_YEAST

UniProt ID

Q12466

Species

Yeast (S288c)

Comments

Comment Type	Description
Cofactor	Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
Cofactor	Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ;
Domain	The C-terminal C2 domain shows Ca(2+)-dependent phospholipid binding. It binds to phosphatidylserine, phosphatidylinositol and various phosphoinositides. The other C2 domains do not retain all 5 conserved Asp residues found in calcium-binding C2 domains.
Function	May play a role in membrane trafficking
Function	May play a role in membrane trafficking. {ECO:0000269\|PubMed:15049706, ECO:0000269\|PubMed:15141306}.
Interaction	P43603:LSB3; NbExp=1; IntAct=EBI-34614, EBI-22980; Q03640:TCB3; NbExp=1; IntAct=EBI-34614, EBI-27872;
Miscellaneous	Present with 6140 molecules/cell in log phase SD medium
Miscellaneous	Present with 6140 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the tricalbin family
Similarity	Belongs to the tricalbin family. {ECO:0000305}.
Similarity	Contains 3 C2 domains. {ECO:0000255\|PROSITE- ProRule:PRU00041}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269\|PubMed:14562095}.
Subcellular Location	Cell membrane ; Multi-pass membrane protein .
Subunit	Interacts with TCB2 via its C-terminal domain
Subunit	Interacts with TCB2 via its C-terminal domain. {ECO:0000269\|PubMed:15141306}.