LIPID MAPS

LMPD ID

LMP007327

Gene ID

853405

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

succinate dehydrogenase SDH1b

Gene Symbol

YJL045W

Synonyms

-

Chromosome

X

EC Number

1.3.5.1

succinate dehydrogenase SDH1b
Refseq ID	NP_012490
Protein GI	6322416
UniProt ID	P47052
mRNA ID	NM_001181478
Length	634
MLSLKKGITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYKTACLSKLFPTRSHTVAAQGGINAALGNMHPDDWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVIELEHYGMPFSRTEDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFFIEYFAMDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRAITMEIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMGGIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVANTIADTLQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNITEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTAVSASKRKESRGAHAREDYAKRDDVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENECAPVPPAVRSY

Entrez Gene ID

853405

Gene Name

succinate dehydrogenase SDH1b

Gene Symbol

YJL045W

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005743	IEA:UniProtKB-KW	C	mitochondrial inner membrane
GO:0050660	IEA:InterPro	F	flavin adenine dinucleotide binding
GO:0008177	IMP:SGD	F	succinate dehydrogenase (ubiquinone) activity
GO:0045333	IMP:SGD	P	cellular respiration
GO:0022900	IEA:InterPro	P	electron transport chain
GO:0006099	IEA:UniProtKB-UniPathway	P	tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko01200	Carbon metabolism
sce01200	Carbon metabolism
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
sce_M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
ko00020	Citrate cycle (TCA cycle)
sce00020	Citrate cycle (TCA cycle)
M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce_M00009	Citrate cycle (TCA cycle, Krebs cycle)
sce01100	Metabolic pathways
ko00190	Oxidative phosphorylation
sce00190	Oxidative phosphorylation
M00148	Succinate dehydrogenase (ubiquinone)
sce_M00148	Succinate dehydrogenase (ubiquinone)

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-7279-YEAST	aerobic respiration (cytochrome c)
PWY3O-188	aerobic respiration (linear view)
TCA-EUK-PWY-YEAST	TCA cycle, aerobic respiration

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618051	Citric acid cycle (TCA cycle)
5618023	Metabolism
5618052	Pyruvate metabolism and Citric Acid (TCA) cycle
5618290	Respiratory electron transport
5618291	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5618053	The citric acid (TCA) cycle and respiratory electron transport

InterPro Annotations

Accession	Description
IPR003953	FAD binding domain
IPR003952	Fumarate reductase/succinate dehydrogenase, FAD-binding site
IPR015939	Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR011281	Succinate dehydrogenase, flavoprotein subunit
IPR027477	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
IPR014006	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Entry Information

Gene Name

succinate dehydrogenase SDH1b

Protein Entry

SDHX_YEAST

UniProt ID

P47052

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Succinate + a quinone = fumarate + a quinol.
Cofactor	Name=FAD; Xref=ChEBI:CHEBI:57692;
Function	Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4
Function	Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4. {ECO:0000269\|PubMed:9730279}.
Miscellaneous	In vitro, can complement a SDH1 disruption and leads to less than 15% of wild-type SDH reductase activity probably due to its lower expression level (compared to SDH1).
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Similarity	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
Similarity	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Subunit	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit
Subunit	Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. {ECO:0000250}.