Gene/Proteome Database (LMPD)
Proteins
| dihydrolipoyllysine-residue acetyltransferase | |
|---|---|
| Refseq ID | NP_014328 |
| Protein GI | 398365063 |
| UniProt ID | P12695 |
| mRNA ID | NM_001182909 |
| Length | 482 |
| RefSeq Status | PROVISIONAL |
| MSAFVRVVPRISRSSVLTRSLRLQLRCYASYPEHTIIGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPVNKPIAVYVEDKADVPAFKDFKLEDSGSDSKTSTKAQPAEPQAEKKQEAPAEETKTSAPEAKKSDVAAPQGRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKSSKQSSQTSGAAAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISKLLKLRQSLNATANDKYKLSINDLLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAPEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQVTITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL | |
Gene Information
Entrez Gene ID
Gene Name
dihydrolipoyllysine-residue acetyltransferase
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005967 | IDA:SGD | C | mitochondrial pyruvate dehydrogenase complex |
| GO:0004742 | IDA:SGD | F | dihydrolipoyllysine-residue acetyltransferase activity |
| GO:0006086 | IDA:SGD | P | acetyl-CoA biosynthetic process from pyruvate |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
| IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
| IPR000089 | Biotin/lipoyl attachment |
| IPR023213 | Chloramphenicol acetyltransferase-like domain |
| IPR006257 | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| IPR004167 | E3-binding domain |
| IPR011053 | Single hybrid motif |
UniProt Annotations
Entry Information
Gene Name
dihydrolipoyllysine-residue acetyltransferase
Protein Entry
ODP2_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
| Cofactor | Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.; |
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). {ECO:0000269|PubMed:7030741}. |
| Miscellaneous | Present with 5440 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Miscellaneous | The E2 component contains covalently-bound lipoyl cofactors and it participates in the generation of acetyl groups from hydroxyethyl-thiamine pyrophosphate-E1 and their transfer to coenzyme A. |
| Similarity | Belongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}. |
| Similarity | Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:14562095}. |
| Subunit | Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds. {ECO:0000269|PubMed:7030741}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007331 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 398365063 | RefSeq | NP_014328 | 482 | dihydrolipoyllysine-residue acetyltransferase |
Identical Sequences to LMP007331 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365063 | GenBank | EDZ69677.1 | 482 | YNL071Wp-like protein [Saccharomyces cerevisiae AWRI1631] |
| GI:398365063 | GenBank | EIW08021.1 | 482 | Lat1p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:398365063 | GenBank | AGP21943.1 | 482 | Sequence 106 from patent US 8465964 |
| GI:398365063 | GenBank | EWG89157.1 | 482 | Lat1p [Saccharomyces cerevisiae P301] |
| GI:398365063 | GenBank | AIB02138.1 | 482 | Sequence 87 from patent US 8669094 |
| GI:398365063 | Third Party Genbank | DAA10474.1 | 482 | TPA: dihydrolipoyllysine-residue acetyltransferase [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007331 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398365063 | GenBank | EEU09356.1 | 482 | Lat1p [Saccharomyces cerevisiae JAY291] |
| GI:398365063 | GenBank | EGA77098.1 | 482 | Lat1p [Saccharomyces cerevisiae Vin13] |
| GI:398365063 | GenBank | EGA85075.1 | 482 | Lat1p [Saccharomyces cerevisiae VL3] |
| GI:398365063 | GenBank | EWG83770.1 | 482 | Lat1p [Saccharomyces cerevisiae R008] |
| GI:398365063 | GenBank | EWH16512.1 | 482 | Lat1p [Saccharomyces cerevisiae P283] |
| GI:398365063 | gnl | McCuskerlabDuke | 482 | Lat1p [Saccharomyces cerevisiae YJM993] |