LIPID MAPS

LMPD ID

LMP007339

Gene ID

850553

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Ypi1p

Gene Symbol

YPI1

Synonyms

-

Chromosome

VI

Ypi1p
Refseq ID	NP_116658
Protein GI	14318525
UniProt ID	P43587
mRNA ID	NM_001179968
Length	155
MSGNQMAMGSEQQQTVGSRTVSVEEVPAVLQLRATQDPPRSQEAMPTRHNVRWEENVIDNENMNKKKTKICCIFHPQNEDEEECNHHSDDDGSSSSGSSSSESENEKDLDFNERRQRRLERRHRKLEKKRSYSPNAYEIQPDYSEYRRKQQEKKD

Entrez Gene ID

850553

Gene Name

Ypi1p

Gene Symbol

YPI1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005634	IDA:SGD	C	nucleus
GO:0071862	IGI:SGD	F	protein phosphatase type 1 activator activity
GO:0004865	IDA:SGD	F	protein serine/threonine phosphatase inhibitor activity
GO:0006873	IMP:SGD	P	cellular ion homeostasis
GO:0005977	IMP:SGD	P	glycogen metabolic process
GO:0007094	IGI:SGD	P	mitotic spindle assembly checkpoint
GO:0032515	IDA:SGD	P	negative regulation of phosphoprotein phosphatase activity
GO:0035308	IDA:SGD	P	negative regulation of protein dephosphorylation
GO:0032516	IGI:SGD	P	positive regulation of phosphoprotein phosphatase activity
GO:1900180	IDA:SGD	P	regulation of protein localization to nucleus

InterPro Annotations

Accession	Description
IPR011107	PPI_Ypi1

Entry Information

Gene Name

Ypi1p

Protein Entry

YPI1_YEAST

UniProt ID

P43587

Species

Yeast (S288c)

Comments

Comment Type	Description
Caution	Was originally (PubMed:14506263) thought to be an inhibitor of type 1 phosphatases using in vitro experiments, but further in vivo experiments (PubMed:18172024) showed that it was rather an activator of these phosphatases
Caution	Was originally (PubMed:14506263) thought to be an inhibitor of type 1 phosphatases using in vitro experiments, but further in vivo experiments (PubMed:18172024) showed that it was rather an activator of these phosphatases. {ECO:0000305\|PubMed:14506263, ECO:0000305\|PubMed:18172024}.
Function	Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control. Regulates the nuclear localization of type 1 phosphatase GLC7 and SDS22, and is involved in the regulation of mRNA 3'-end processing. May also regulate the activity of type 1 phosphatase PPZ1. {ECO:0000269\|PubMed:14506263, ECO:0000269\|PubMed:16137619, ECO:0000269\|PubMed:17142459, ECO:0000269\|PubMed:18172024}.
Interaction	P32598:GLC7; NbExp=4; IntAct=EBI-22913, EBI-13715; P36047:SDS22; NbExp=4; IntAct=EBI-22913, EBI-16783;
Miscellaneous	Present with 1080 molecules/cell in log phase SD medium
Miscellaneous	Present with 1080 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity	Belongs to the YPI1 family
Similarity	Belongs to the YPI1 family. {ECO:0000305}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:17142459, ECO:0000269\|PubMed:18172024}.
Subunit	Interacts with GLC7, PPZ1 and SDS22. {ECO:0000269\|PubMed:14506263, ECO:0000269\|PubMed:17142459, ECO:0000269\|PubMed:18172024}.