Gene/Proteome Database (LMPD)

LMPD ID
LMP007343
Gene ID
855637
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Tcb2p
Gene Symbol
TCB2
Synonyms
-
Alternate Names
Tcb2p
Chromosome
XIV

Proteins

Tcb2p
Refseq ID NP_014312
Protein GI 6324242
UniProt ID P48231
mRNA ID NM_001182925
Length 1178
RefSeq Status PROVISIONAL
MSPNSSKTRTDQISSMPGINEATKVESKNVVKDAVPIKSEVETNGTSIVREKQDPSYVGWKQVGGWEEKDELTSEDLLVDVNKDTFLGNLLPDKFYGDWYHEVAILIIAGLCSFVLGYFKFSLASVLIVMLTTGMLYRTSSKKYRESLRDLAQKEQTVEKITSDYESVEWLNTFLDKYWPIIEPSVSQQIVDGTNTALSENVAIPKFIKAIWLDQFTLGVKPPRIDAIKTFQNTKSDVVVMDVCLSFTPHDMSDLDAKQCRNYVNSNVVLKAKIFGMDIPVSVADIFFQVFVRFRFQLMTTLPLVETINIQLLEVPEVDFISRLLGNSVFNWEILAIPGLMRLIQKMAFKYLSPVLLPPFSLQLNIPQLLSKTGLPIGVLEIKVKNAHGLRKLVGMIKKTVDPYLTFELSGKIVGKTKVFKNSANPVWNESIYILLQSFTDPLTIAVYDKRETLSDKKMGTVIFNLNKLHANHYHKNEKVHFLRNSKPVGELTFDLRFFPTIEPKKLLNGDEEPLPDMNTGITKITIRELKGLDELSDKKFVFAELYVNAELVMTTKKEKRTAHLKWNSDYYSVVTDRRKTICRFVLKDQSGKVISSSVQPLNHLIDRTEVNKEWIPLRNGKGELKVTTYWRPVDIDLGLKSVGYTTPIGMLRVFINKAENLRNPDSLGKISPYAKVSVNGVARGRTNERIETLNPIWNQSIYVSVTSPLQKVSIDCFGIDTNGDDHNLGSLNIQTQNIYHKDNDDKYTIFIDNAPRTGNLIGKKGVKGTVTYYLSFYPVVPVLSLEEAKEVDEINEKKDKLEKQKSTLDDKNISKEEKERIKKEEFRLTEKYDMYSYKMKLDLDELLQYNAGVLGVTVLGGELPQPGLYVQTFFDSCGYAAITSAKNAIRTIKTGWSGDFMIKELEWSVTTFRVTKTKDANKAENFICEVNIPTIELVRNCYYKPSVLNLIGKKSAKLLVQVSWFPVTATELPQSDLITNSGDLKITAKSAENLIGVNKNGYSDPYVEFFLNEKSTSPFFKTAVQKKTLNPTWNESKTIEVSNRVNDYLTINVKDYESTNSNRSIGKAVVPLSTIDPESDTTFNIPLVGPKGEDGGVLHLEFEFEPRYTTNVVKREAGLGNFATKGLGTGIKAGSTVFALGTNVVSTGLGTIDKVKAGVFGGKKSTTTGDKKSEEKQ

Gene Information

Entrez Gene ID
855637
Gene Name
Tcb2p
Gene Symbol
TCB2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005933 IDA:SGD C cellular bud
GO:0032541 IDA:SGD C cortical endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008289 IDA:SGD F lipid binding
GO:0090158 IGI:SGD P endoplasmic reticulum membrane organization
GO:0060304 IGI:SGD P regulation of phosphatidylinositol dephosphorylation

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR017147 Tricalbin

UniProt Annotations

Entry Information

Gene Name
Tcb2p
Protein Entry
TCB2_YEAST
UniProt ID
P48231
Species
Yeast (S288c)

Comments

Comment Type Description
Domain The C2 domains show Ca(2+)-independent phospholipid binding. None of the C2 domains retains all 5 conserved Asp residues found in calcium-binding C2 domains.
Function May play a role in membrane trafficking. {ECO:0000269|PubMed:15049706, ECO:0000269|PubMed:15141306}.
Interaction Q03640:TCB3; NbExp=1; IntAct=EBI-28779, EBI-27872; Q07824:TPO1; NbExp=1; IntAct=EBI-28779, EBI-38106;
Miscellaneous Present with 2630 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the tricalbin family. {ECO:0000305}.
Similarity Contains 3 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Traffics from the cell surface to intracellular vesicles near the vacuole. {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15141306}.
Subunit Interacts with TCB1 and TCB3 via its C-terminal domain. {ECO:0000269|PubMed:15141306}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007343 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324242 RefSeq NP_014312 1178 Tcb2p

Identical Sequences to LMP007343 proteins

Reference Database Accession Length Protein Name
GI:6324242 EMBL CAA61423.1 1178 ORF N2250 [Saccharomyces cerevisiae]
GI:6324242 EMBL CAA95963.1 1178 unnamed protein product [Saccharomyces cerevisiae]
GI:6324242 GenBank EIW08004.1 1178 Tcb2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6324242 SwissProt P48231.1 1178 RecName: Full=Tricalbin-2 [Saccharomyces cerevisiae S288c]
GI:6324242 Third Party Genbank DAA10458.1 1178 TPA: Tcb2p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007343 proteins

Reference Database Accession Length Protein Name
GI:6324242 GenBank EDN62725.1 1178 conserved protein [Saccharomyces cerevisiae YJM789]
GI:6324242 GenBank EEU05480.1 1178 Tcb2p [Saccharomyces cerevisiae JAY291]
GI:6324242 GenBank EWG83754.1 1178 Tcb2p [Saccharomyces cerevisiae R008]
GI:6324242 GenBank EWG93804.1 1178 Tcb2p [Saccharomyces cerevisiae R103]
GI:6324242 GenBank EWH16498.1 1178 Tcb2p [Saccharomyces cerevisiae P283]
GI:6324242 gnl McCuskerlabDuke 1178 Tcb2p [Saccharomyces cerevisiae YJM993]