Gene/Proteome Database (LMPD)

LMPD ID
LMP007350
Gene ID
850824
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
bifunctional choline kinase/ethanolamine kinase CKI1
Gene Symbol
CKI1
Synonyms
-
Alternate Names
bifunctional choline kinase/ethanolamine kinase CKI1
Chromosome
XII
EC Number
2.7.1.32

Proteins

bifunctional choline kinase/ethanolamine kinase CKI1
Refseq ID NP_013234
Protein GI 6323162
UniProt ID P20485
mRNA ID NM_001182020
Length 582
RefSeq Status PROVISIONAL
MVQESRPGSVRSYSVGYQARSRSSSQRRHSLTRQRSSQRLIRTISIESDVSNITDDDDLRAVNEGVAGVQLDVSETANKGPRRASATDVTDSLGSTSSEYIEIPFVKETLDASLPSDYLKQDILNLIQSLKISKWYNNKKIQPVAQDMNLVKISGAMTNAIFKVEYPKLPSLLLRIYGPNIDNIIDREYELQILARLSLKNIGPSLYGCFVNGRFEQFLENSKTLTKDDIRNWKNSQRIARRMKELHVGVPLLSSERKNGSACWQKINQWLRTIEKVDQWVGDPKNIENSLLCENWSKFMDIVDRYHKWLISQEQGIEQVNKNLIFCHNDAQYGNLLFTAPVMNTPSLYTAPSSTSLTSQSSSLFPSSSNVIVDDIINPPKQEQSQDSKLVVIDFEYAGANPAAYDLANHLSEWMYDYNNAKAPHQCHADRYPDKEQVLNFLYSYVSHLRGGAKEPIDEEVQRLYKSIIQWRPTVQLFWSLWAILQSGKLEKKEASTAITREEIGPNGKKYIIKTEPESPEEDFVENDDEPEAGVSIDTFDYMAYGRDKIAVFWGDLIGLGIITEEECKNFSSFKFLDTSYL

Gene Information

Entrez Gene ID
850824
Gene Name
bifunctional choline kinase/ethanolamine kinase CKI1
Gene Symbol
CKI1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004103 IDA:SGD F choline kinase activity
GO:0004305 IMP:SGD F ethanolamine kinase activity
GO:0006657 IDA:GOC P CDP-choline pathway
GO:0006656 IMP:SGD P phosphatidylcholine biosynthetic process
GO:0006646 IMP:SGD P phosphatidylethanolamine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce00564 Glycerophospholipid metabolism
sce_M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC

REACTOME Pathway Links

REACTOME Pathway ID Description
5618446 Synthesis of PC
5618597 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR007521 Choline kinase, N-terminal
IPR026712 Choline/Ethanolamine kinase
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
bifunctional choline kinase/ethanolamine kinase CKI1
Protein Entry
KICH_YEAST
UniProt ID
P20485
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + choline = ADP + phosphocholine.
Function Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline.
Interaction P25293:NAP1; NbExp=5; IntAct=EBI-9699, EBI-11850;
Miscellaneous Present with 3930 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
Similarity Belongs to the choline/ethanolamine kinase family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Monomer. Interacts with NAP1. {ECO:0000269|PubMed:18086883}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007350 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323162 RefSeq NP_013234 582 bifunctional choline kinase/ethanolamine kinase CKI1

Identical Sequences to LMP007350 proteins

Reference Database Accession Length Protein Name
GI:6323162 EMBL CAA97704.1 582 CKI1 [Saccharomyces cerevisiae]
GI:6323162 EMBL CAY37232.1 582 unnamed protein product [Saccharomyces cerevisiae]
GI:6323162 GenBank AAT92798.1 582 YLR133W [Saccharomyces cerevisiae]
GI:6323162 GenBank ABZ48387.1 582 Sequence 22325 from patent US 7314974
GI:6323162 GenBank EIW08749.1 582 Cki1p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323162 Third Party Genbank DAA09444.1 582 TPA: bifunctional choline kinase/ethanolamine kinase CKI1 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007350 proteins

Reference Database Accession Length Protein Name
GI:6323162 GenBank EEU06996.1 582 Cki1p [Saccharomyces cerevisiae JAY291]
GI:6323162 GenBank EWG84391.1 582 Cki1p [Saccharomyces cerevisiae R008]
GI:6323162 GenBank EWG89906.1 582 Cki1p [Saccharomyces cerevisiae P301]
GI:6323162 GenBank EWG94731.1 582 Cki1p [Saccharomyces cerevisiae R103]
GI:6323162 GenBank EWH17288.1 582 Cki1p [Saccharomyces cerevisiae P283]
GI:6323162 gnl McCuskerlabDuke 582 Cki1p [Saccharomyces cerevisiae YJM993]