Gene/Proteome Database (LMPD)

LMPD ID
LMP007354
Gene ID
851286
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
oxysterol-binding protein related protein SWH1
Gene Symbol
SWH1
Synonyms
OSH1; YAR044W
Alternate Names
oxysterol-binding protein related protein SWH1
Chromosome
I

Proteins

oxysterol-binding protein related protein SWH1
Refseq ID NP_009421
Protein GI 85666110
UniProt ID P35845
mRNA ID NM_001178227
Length 1188
RefSeq Status PROVISIONAL
MEQPDLSSVAISKPLLKLKLLDALRQGSFPNLQDLLKKQFQPLDDPNVQQVLHLMLHYAVQVAPMAVIKEIVHHWVSTTNTTFLNIHLDLNERDSNGNTPLHIAAYQSRGDIVAFLLDQPTINDCVLNNSHLQAIEMCKNLNIAQMMQVKRSTYVAETAQEFRTAFNNRDFGHLESILSSPRNAELLDINGMDPETGDTVLHEFVKKRDVIMCRWLLEHGADPFKRDRKGKLPIELVRKVNENDTATNTKIAIDIELKKLLERATREQSVIDVTNNNLHEAPTYKGYLKKWTNFAQGYKLRWFILSSDGKLSYYIDQADTKNACRGSLNMSSCSLHLDSSEKLKFEIIGGNNGVIRWHLKGNHPIETNRWVWAIQGAIRYAKDREILLHNGPYSPSLALSHGLSSKVSNKENLHATSKRLTKSPHLSKSTLTQNDHDNDDDSTNNNNNKSNNDYDDNNNNNNNDDDDYDDDDESRPLIEPLPLISSRSQSLSEITPGPHSRKSTVSSTRAADIPSDDEGYSEDDSDDDGNSSYTMENGGENDGDEDLNAIYGPYIQKLHMLQRSISIELASLNELLQDKQQHDEYWNTVNTSIETVSEFFDKLNRLTSQREKRMIAQMTKQRDVNNVWIQSVKDLEMELVDKDEKLVALDKERKNLKKMLQKKLNNQPQVETEANEESDDANSMIKGSQESTNTLEEIVKFIEATKESDEDSDADEFFDAEEAASDKKANDSEDLTTNKETPANAKPQEEAPEDESLIVISSPQVEKKNQLLKEGSFVGYEDPVRTKLALDEDNRPKIGLWSVLKSMVGQDLTKLTLPVSFNEPTSLLQRVSEDIEYSHILDQAATFEDSSLRMLYVAAFTASMYASTTNRVSKPFNPLLGETFEYARTDGQYRFFTEQVSHHPPISATWTESPKWDFYGECNVDSSFNGRTFAVQHLGLWYITIRPDHNISVPEETYSWKKPNNTVIGILMGKPQVDNSGDVKVTNHTTGDYCMLHYKAHGWTSAGAYEVRGEVFNKDDKKLWVLGGHWNDSIYGKKVTARGGELTLDRIKTANSATGGPKLDGSKFLIWKANERPSVPFNLTSFALTLNALPPHLIPYLAPTDSRLRPDQRAMENGEYDKAAAEKHRVEVKQRAAKKEREQKGEEYRPKWFVQEEHPVTKSLYWKFNGEYWNKRKNHDFKDCADIF

Gene Information

Entrez Gene ID
851286
Gene Name
oxysterol-binding protein related protein SWH1
Gene Symbol
SWH1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000138 IDA:SGD C Golgi trans cisterna
GO:0005769 IDA:SGD C early endosome
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005635 IDA:SGD C nuclear envelope
GO:0005545 ISS:SGD F 1-phosphatidylinositol binding
GO:0008289 IDA:SGD F lipid binding
GO:0008142 ISS:SGD F oxysterol binding
GO:0015248 IDA:SGD F sterol transporter activity
GO:0006897 IGI:SGD P endocytosis
GO:0006887 IGI:SGD P exocytosis
GO:0030011 IGI:SGD P maintenance of cell polarity
GO:0015918 IDA:SGD P sterol transport

Domain Information

InterPro Annotations

Accession Description
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol-binding protein related protein SWH1
Protein Entry
OSH1_YEAST
UniProt ID
P35845
Species
Yeast (S288c)

Comments

Comment Type Description
Domain The FFAT motif is required for interaction with SCS2 and proper localization of the protein. {ECO:0000269|PubMed:12727870}.
Domain The PH domain is required for targeting the protein to the late Golgi. {ECO:0000269|PubMed:12727870}.
Domain The ankyrin repeats are required for targeting the protein to the NV junction. {ECO:0000269|PubMed:12727870}.
Function Lipid-binding protein involved in maintenance of intracellular sterol distribution and homeostasis. Binds to phosphoinositides. May be involved in formation of PMN vesicles by altering the membrane lipid composition. {ECO:0000269|PubMed:15173322}.
Similarity Belongs to the OSBP family. {ECO:0000305}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Cytoplasm. Golgi apparatus membrane. Nucleus outer membrane. Note=Soluble protein that accumulates on the surface of late Golgi membranes and at nucleus-vacuole (NV) junctions, interorganelle interfaces between the nuclear envelope and the vacuole membrane formed during piecemeal microautophagy of the nucleus (PMN). Targeted exclusively to NV junctions in stationary phase.
Subunit Interacts with NVJ1. {ECO:0000269|PubMed:15367582}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007354 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
85666110 RefSeq NP_009421 1188 oxysterol-binding protein related protein SWH1

Identical Sequences to LMP007354 proteins

Reference Database Accession Length Protein Name
GI:85666110 GenBank AAP31019.1 1188 oxysterol-binding protein-like protein 1 [Saccharomyces cerevisiae]
GI:85666110 SwissProt P35845.4 1188 RecName: Full=Oxysterol-binding protein homolog 1 [Saccharomyces cerevisiae S288c]
GI:85666110 Third Party Genbank DAA07006.1 1188 TPA: oxysterol-binding protein related protein SWH1 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007354 proteins

Reference Database Accession Length Protein Name
GI:85666110 EMBL CAY77670.1 1186 Swh1p [Saccharomyces cerevisiae EC1118]
GI:85666110 GenBank AAC09496.2 1188 Yar042wp [Saccharomyces cerevisiae]
GI:85666110 GenBank EEU08905.1 1188 Swh1p [Saccharomyces cerevisiae JAY291]
GI:85666110 GenBank EWG87937.1 1187 Swh1p [Saccharomyces cerevisiae R008]
GI:85666110 GenBank EWH19741.1 1188 Swh1p [Saccharomyces cerevisiae P283]
GI:85666110 gnl McCuskerlabDuke 1188 Swh1p [Saccharomyces cerevisiae YJM993]