LIPID MAPS

LMPD ID

LMP007361

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Plb1p

Gene Symbol

PLB1

Synonyms

-

Chromosome

XIII

EC Number

3.1.1.5

Plb1p
Refseq ID	NP_013721
Protein GI	6323650
UniProt ID	P39105
mRNA ID	NM_001182504
Length	664
MKLQSLLVSAAVLTSLTENVNAWSPNNSYVPANVTCDDDINLVREASGLSDNETEWLKKRDAYTKEALHSFLNRATSNFSDTSLLSTLFGSNSSNMPKIAVACSGGGYRAMLSGAGMLAAMDNRTDGANEHGLGGLLQGATYLAGLSGGNWLTSTLAWNNWTSVQAIVDNTTESNSIWDISHSILTPDGINIFKTGSRWDDISDDVQDKKDAGFNISLADVWGRALAYNFWPSLHRGGVGYTWSTLREADVFKNGEMPFPITVADGRYPGTTVINLNATLFEFNPFEMGSWDPTLNAFTDVKYLGTNVTNGKPVNKGQCIAGFDNTGFITATSSTLFNQFLLRLNSTDLPSFIANLATDFLEDLSDNSDDIAIYAPNPFKEANFLQKNATSSIIESEYLFLVDGGEDNQNIPLVPLLQKERELDVIFALDNSADTDDYWPDGASLVNTYQRQFGSQGLNLSFPYVPDVNTFVNLGLNKKPTFFGCDARNLTDLEYIPPLIVYIPNSRHSFNGNQSTFKMSYSDSERLGMIKNGFEAATMGNFTDDSDFLGCVGCAIIRRKQQNLNATLPSECSQCFTNYCWNGTIDSRSVSGVGNDDYSSSASLSASAAAASASASASASASASASGSSTHKKNAGNALVNYSNLNTNTFIGVLSVISAVFGLI

Entrez Gene ID

Gene Name

Plb1p

Gene Symbol

PLB1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0031225	IEA:UniProtKB-KW	C	anchored component of membrane
GO:0042597	IDA:SGD	C	periplasmic space
GO:0005886	IDA:SGD	C	plasma membrane
GO:0004622	IMP:SGD	F	lysophospholipase activity
GO:0006650	IMP:SGD	P	glycerophospholipid metabolic process
GO:0036151	IMP:SGD	P	phosphatidylcholine acyl-chain remodeling
GO:0009395	IEA:InterPro	P	phospholipid catabolic process

KEGG Pathway ID	Description
ko00564	Glycerophospholipid metabolism
sce00564	Glycerophospholipid metabolism

BIOCYC Pathway ID	Description
PWY-7409	phospholipid remodeling (phosphatidylethanolamine)
PWY-7409	phospholipid remodeling (phosphatidylethanolamine, yeast)

Accession	Description
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR002642	Lysophospholipase, catalytic domain

Gene Name

Plb1p

Protein Entry

PLB1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Catalytic Activity	2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Function	Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol >> phosphatidylcholine > phosphatidylethanolamine. {ECO:0000269\|PubMed:10497163, ECO:0000269\|PubMed:8051052}.
Interaction	P38800:YHR080C; NbExp=1; IntAct=EBI-13462, EBI-24597;
Similarity	Belongs to the lysophospholipase family
Similarity	Belongs to the lysophospholipase family. {ECO:0000305}.
Similarity	Contains 1 PLA2c domain. {ECO:0000255\|PROSITE- ProRule:PRU00555}.
Subcellular Location	Cell membrane {ECO:0000305\|PubMed:10383953, ECO:0000305\|PubMed:10497163}; Lipid-anchor, GPI-anchor .
Subcellular Location	Cell membrane {ECO:0000305\|PubMed:10383953, ECO:0000305\|PubMed:10497163}; Lipid-anchor, GPI-anchor {ECO:0000305\|PubMed:10383953, ECO:0000305\|PubMed:10497163}.