LIPID MAPS

LMPD ID

LMP007382

Gene ID

855986

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

isopentenyl-diphosphate delta-isomerase IDI1

Gene Symbol

IDI1

Synonyms

BOT2; LPH10

Chromosome

XVI

EC Number

5.3.3.2

isopentenyl-diphosphate delta-isomerase IDI1
Refseq ID	NP_015208
Protein GI	6325140
UniProt ID	P15496
mRNA ID	NM_001183931
Length	288
MTADNNSMPHGAVSSYAKLVQNQTPEDILEEFPEIIPLQQRPNTRSSETSNDESGETCFSGHDEEQIKLMNENCIVLDWDDNAIGAGTKKVCHLMENIEKGLLHRAFSVFIFNEQGELLLQQRATEKITFPDLWTNTCCSHPLCIDDELGLKGKLDDKIKGAITAAVRKLDHELGIPEDETKTRGKFHFLNRIHYMAPSNEPWGEHEIDYILFYKINAKENLTVNPNVNEVRDFKWVSPNDLKTMFADPSYKFTPWFKIICENYLFNWWEQLDDLSEVENDRQIHRML

Entrez Gene ID

855986

Gene Name

isopentenyl-diphosphate delta-isomerase IDI1

Gene Symbol

IDI1

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-KW	C	cytoplasm
GO:0016787	IEA:InterPro	F	hydrolase activity
GO:0004452	IDA:SGD	F	isopentenyl-diphosphate delta-isomerase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0050992	IEA:UniProtKB-UniPathway	P	dimethylallyl diphosphate biosynthetic process
GO:0045337	IDA:SGD	P	farnesyl diphosphate biosynthetic process
GO:0016126	IEA:UniProtKB-KW	P	sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
M00095	C5 isoprenoid biosynthesis, mevalonate pathway
sce_M00095	C5 isoprenoid biosynthesis, mevalonate pathway
sce01100	Metabolic pathways
ko00900	Terpenoid backbone biosynthesis
sce00900	Terpenoid backbone biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY-6859	all-trans-farnesol biosynthesis
HEXPPSYN-PWY-1	hexaprenyl diphosphate biosynthesis
PWY-7391	isoprene biosynthesis II (engineered)
PWY-922	mevalonate pathway
PWY-922	mevalonate pathway I
ERGOSTEROL-SYN-PWY	superpathway of ergosterol biosynthesis
ERGOSTEROL-SYN-PWY	superpathway of ergosterol biosynthesis I
PWY-5910	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5910	superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5123	trans, trans-farnesyl diphosphate biosynthesis
PWY-5123	trans, trans-farnesyl diphosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5618346	Cholesterol biosynthesis
5618023	Metabolism
5618091	Metabolism of lipids and lipoproteins

InterPro Annotations

Accession	Description
IPR011876	Isopentenyl-diphosphate delta-isomerase, type 1
IPR000086	NUDIX hydrolase domain
IPR015797	NUDIX hydrolase domain-like

Entry Information

Gene Name

isopentenyl-diphosphate delta-isomerase IDI1

Protein Entry

IDI1_YEAST

UniProt ID

P15496

Species

Yeast (S288c)

Comments

Comment Type	Description
Catalytic Activity	Isopentenyl diphosphate = dimethylallyl diphosphate.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 1 Mg(2+) ion per subunit. ;
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Interaction	Self; NbExp=1; IntAct=EBI-8902, EBI-8902; P53090:ARO8; NbExp=1; IntAct=EBI-8902, EBI-2042933; P10174:COX7; NbExp=1; IntAct=EBI-8902, EBI-2050505; P22696:ESS1; NbExp=1; IntAct=EBI-8902, EBI-6679; P32288:GLN1; NbExp=1; IntAct=EBI-8902, EBI-7665; P53978:HEF3; NbExp=1; IntAct=EBI-8902, EBI-6345; P00817:IPP1; NbExp=1; IntAct=EBI-8902, EBI-9338; P33203:PRP40; NbExp=1; IntAct=EBI-8902, EBI-701; P38206:RFT1; NbExp=1; IntAct=EBI-8902, EBI-15028; P21524:RNR1; NbExp=1; IntAct=EBI-8902, EBI-15234; P09938:RNR2; NbExp=1; IntAct=EBI-8902, EBI-15240; Q07979:RSC58; NbExp=1; IntAct=EBI-8902, EBI-36549; P39940:RSP5; NbExp=1; IntAct=EBI-8902, EBI-16219; P53040:TAF6; NbExp=1; IntAct=EBI-8902, EBI-18876; Q12415:TFC7; NbExp=1; IntAct=EBI-8902, EBI-33456; P25386:USO1; NbExp=1; IntAct=EBI-8902, EBI-20157;
Miscellaneous	Present with 25500 molecules/cell in log phase SD medium
Miscellaneous	Present with 25500 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Similarity	Belongs to the IPP isomerase type 1 family
Similarity	Belongs to the IPP isomerase type 1 family. {ECO:0000305}.
Similarity	Contains 1 nudix hydrolase domain
Similarity	Contains 1 nudix hydrolase domain. {ECO:0000255\|PROSITE-ProRule:PRU00794}.
Subcellular Location	Cytoplasm.