Gene/Proteome Database (LMPD)

LMPD ID
LMP007392
Gene ID
854808
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
long-chain fatty acid-CoA ligase FAA3
Gene Symbol
FAA3
Synonyms
-
Chromosome
IX
EC Number
6.2.1.3

Proteins

long-chain fatty acid-CoA ligase FAA3
Refseq ID NP_012257
Protein GI 6322182
UniProt ID P39002
mRNA ID NM_001179359
Length 694
MSEQHSVAVGKAANEHETAPRRNVRVKKRPLIRPLNSSASTLYEFALECFNKGGKRDGMAWRDVIEIHETKKTIVRKVDGKDKSIEKTWLYYEMSPYKMMTYQELIWVMHDMGRGLAKIGIKPNGEHKFHIFASTSHKWMKIFLGCISQGIPVVTAYDTLGESGLIHSMVETESAAIFTDNQLLAKMIVPLQSAKDIKFLIHNEPIDPNDRRQNGKLYKAAKDAINKIREVRPDIKIYSFEEVVKIGKKSKDEVKLHPPEPKDLACIMYTSGSISAPKGVVLTHYNIVSGIAGVGHNVFGWIGSTDRVLSFLPLAHIFELVFEFEAFYWNGILGYGSVKTLTNTSTRNCKGDLVEFKPTIMIGVAAVWETVRKAILEKISDLTPVLQKIFWSAYSMKEKSVPCTGFLSRMVFKKVRQATGGHLKYIMNGGSAISIDAQKFFSIVLCPMIIGYGLTETVANACVLEPDHFEYGIVGDLVGSVTAKLVDVKDLGYYAKNNQGELLLKGAPVCSEYYKNPIETAVSFTYDGWFRTGDIVEWTPKGQLKIIDRRKNLVKTLNGEYIALEKLESVYRSNSYVKNICVYADESRVKPVGIVVPNPGPLSKFAVKLRIMKKGEDIENYIHDKALRNAVFKEMIATAKSQGLVGIELLCGIVFFDEEWTPENGFVTSAQKLKRREILAAVKSEVERVYKENS

Gene Information

Entrez Gene ID
854808
Gene Name
long-chain fatty acid-CoA ligase FAA3
Gene Symbol
FAA3
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:SGD F long-chain fatty acid-CoA ligase activity
GO:0031957 IDA:SGD F very long-chain fatty acid-CoA ligase activity
GO:0001676 IGI:SGD P long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00086 beta-Oxidation, acyl-CoA synthesis
sce_M00086 beta-Oxidation, acyl-CoA synthesis
ko00061 Fatty acid biosynthesis
sce00061 Fatty acid biosynthesis
ko00071 Fatty acid degradation
sce00071 Fatty acid degradation
ko01212 Fatty acid metabolism
sce01212 Fatty acid metabolism
sce01100 Metabolic pathways
ko04146 Peroxisome
sce04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5143 fatty acid activation
PWY-7288 fatty acid beta-oxidation (peroxisome)
YEAST-FAO-PWY fatty acid oxidation (non-cyclic)

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
long-chain fatty acid-CoA ligase FAA3
Protein Entry
LCF3_YEAST
UniProt ID
P39002
Species
Yeast (S288c)

Comments

Comment Type Description
Biophysicochemical Properties Temperature dependence: Optimum temperature is 25 degrees Celsius.;
Biophysicochemical Properties Temperature dependence: Optimum temperature is 25 degrees Celsius.;
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10.
Miscellaneous Present with 6440 molecules/cell in log phase SD medium
Miscellaneous Present with 6440 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subunit Interacts with FRK1
Subunit Interacts with FRK1. {ECO:0000269|PubMed:20489023}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007392 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6322182 RefSeq NP_012257 694 long-chain fatty acid-CoA ligase FAA3

Identical Sequences to LMP007392 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007392 proteins

Reference Database Accession Length Protein Name