Gene/Proteome Database (LMPD)

LMPD ID
LMP007396
Gene ID
851468
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
protein farnesyltransferase
Gene Symbol
RAM1
Synonyms
DPR1; FUS8; SCG2; SGP2; STE16
Chromosome
IV
EC Number
2.5.1.58

Proteins

protein farnesyltransferase
Refseq ID NP_010193
Protein GI 6320113
UniProt ID P22007
mRNA ID NM_001180149
Length 431
MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS

Gene Information

Entrez Gene ID
851468
Gene Name
protein farnesyltransferase
Gene Symbol
RAM1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005965 IDA:SGD C protein farnesyltransferase complex
GO:0004660 IDA:SGD F protein farnesyltransferase activity
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0018343 IDA:SGD P protein farnesylation
GO:0042127 IEA:InterPro P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
sce00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR026872 Protein farnesyltransferase subunit beta
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
protein farnesyltransferase
Protein Entry
FNTB_YEAST
UniProt ID
P22007
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 zinc ion per subunit. ;
Function Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins such as a-factor and RAS. The beta subunit is responsible for peptide-binding.
Interaction P29703:RAM2; NbExp=4; IntAct=EBI-14806, EBI-14814;
Miscellaneous Present with 3910 molecules/cell in log phase SD medium
Miscellaneous Present with 3910 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Similarity Belongs to the protein prenyltransferase subunit beta family
Similarity Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
Similarity Contains 5 PFTB repeats
Similarity Contains 5 PFTB repeats. {ECO:0000305}.
Subunit Heterodimer of an alpha and a beta subunit.

Identical and Related Proteins

Unique RefSeq proteins for LMP007396 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320113 RefSeq NP_010193 431 protein farnesyltransferase

Identical Sequences to LMP007396 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007396 proteins

Reference Database Accession Length Protein Name