LIPID MAPS

LMPD ID

LMP007420

Gene ID

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

trans-hexaprenyltranstransferase

Gene Symbol

COQ1

Synonyms

-

Chromosome

II

EC Number

2.5.1.-

trans-hexaprenyltranstransferase
Refseq ID	NP_009557
Protein GI	6319475
UniProt ID	P18900
mRNA ID	NM_001178351
Length	473
MFQRSGAAHHIKLISSRRCRFKSSFAVALNAASKLVTPKILWNNPISLVSKEMNTLAKNIVALIGSGHPVLNKVTSYYFETEGKKVRPLLVLLLSRALSEIPMTERNHLKIDKSDVPEDPIYSKPSQNQLFQRPASSISPLHILHGIKPLNPLTKGPEPLPEETFDKQRGILPKQRRLAEIVEMIHTASLLHDDVIDHSDTRRGRPSGNAAFTNKMAVLAGDFLLGRATVSISRLHNPEVVELMSNSIANLVEGEFMQLKNTSIDADIDTIENGHKLLPVPSKKLEVKEHDFRVPSRQQGLQLSHDQIIETAFEYYIHKTYLKTAALISKSCRCAAILSGASPAVIDECYDFGRNLGICFQLVDDMLDFTVSGKDLGKPSGADLKLGIATAPVLFAWKEDPSLGPLISRNFSERGDVEKTIDSVRLHNGIAKTKILAEEYRDKALQNLRDSLPESDARSALEFLTNSILTRRK

Entrez Gene ID

Gene Name

trans-hexaprenyltranstransferase

Gene Symbol

COQ1

Species

Saccharomyces cerevisiae S288c

GO ID	Source	Type	Description
GO:0005743	IEA:UniProtKB-KW	C	mitochondrial inner membrane
GO:0005739	IMP:SGD	C	mitochondrion
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0000010	IMP:SGD	F	trans-hexaprenyltranstransferase activity
GO:0008299	IEA:UniProtKB-KW	P	isoprenoid biosynthetic process
GO:0006744	IMP:SGD	P	ubiquinone biosynthetic process

KEGG Pathway ID	Description
sce01110	Biosynthesis of secondary metabolites
ko00900	Terpenoid backbone biosynthesis
sce00900	Terpenoid backbone biosynthesis

BIOCYC Pathway ID	Description
HEXPPSYN-PWY	hexaprenyl diphosphate biosynthesis
HEXPPSYN-PWY-1	hexaprenyl diphosphate biosynthesis

Accession	Description
IPR008949	Isoprenoid synthase domain
IPR000092	Polyprenyl synthetase
IPR017446	Polyprenyl synthetase-related

Gene Name

trans-hexaprenyltranstransferase

Protein Entry

COQ1_YEAST

UniProt ID

Species

Yeast (S288c)

Comment Type	Description
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 3 Mg(2+) ions per subunit. ;
Function	Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species.
Interaction	P10592:SSA2; NbExp=2; IntAct=EBI-4912, EBI-8603;
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium
Miscellaneous	Present with 1560 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity	Belongs to the FPP/GGPP synthase family
Similarity	Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.