Gene/Proteome Database (LMPD)

LMPD ID
LMP007422
Gene ID
855248
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
mevalonate kinase
Gene Symbol
ERG12
Synonyms
RAR1
Alternate Names
mevalonate kinase
Chromosome
XIII
EC Number
2.7.1.36

Proteins

mevalonate kinase
Refseq ID NP_013935
Protein GI 6323864
UniProt ID P07277
mRNA ID NM_001182715
Length 443
RefSeq Status PROVISIONAL
MSLPFLTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSINDFNAITEDQVNSQKLAKAQQATDGLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVCLCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVNQWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYTRIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETNNELYEQLLELIRINHGLLVSIGVSHPGLELIKNLSDDLRIGSTKLTGAGGGGCSLTLLRRDITQEQIDSFKKKLQDDFSYETFETDLGGTGCCLLSAKNLNKDLKIKSLVFQLFENKTTTKQQIDDLLLPGNTNLPWTS

Gene Information

Entrez Gene ID
855248
Gene Name
mevalonate kinase
Gene Symbol
ERG12
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004496 IDA:SGD F mevalonate kinase activity
GO:0006696 IMP:SGD P ergosterol biosynthetic process
GO:0010142 IMP:SGD P farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0019287 IMP:SGD P isopentenyl diphosphate biosynthetic process, mevalonate pathway

KEGG Pathway Links

KEGG Pathway ID Description
sce04146 Peroxisome
sce00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006204 GHMP kinase N-terminal domain
IPR006203 GHMP kinase, ATP-binding, conserved site
IPR013750 GHMP kinase, C-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
mevalonate kinase
Protein Entry
KIME_YEAST
UniProt ID
P07277
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity ATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
Enzyme Regulation Farnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase by binding competitively at the ATP-binding site.
Function May contribute to the regulation of the isoprenoid and sterol pathway in living cells.
Function RAR (regulation of autonomous replication) is a protein whose activity increases the mitotic stability of plasmids.
Miscellaneous Present with 3300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP007422 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323864 RefSeq NP_013935 443 mevalonate kinase

Identical Sequences to LMP007422 proteins

Reference Database Accession Length Protein Name
GI:6323864 DBBJ GAA25657.1 443 K7_Erg12p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6323864 GenBank ADI53348.1 443 Sequence 6 from patent US 7422884
GI:6323864 GenBank EIW08475.1 443 Erg12p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323864 GenBank AFX58121.1 443 Sequence 54 from patent US 8309323
GI:6323864 GenBank AGD02013.1 443 Sequence 1 from patent US 8338155
GI:6323864 Third Party Genbank DAA10107.1 443 TPA: mevalonate kinase [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007422 proteins

Reference Database Accession Length Protein Name
GI:6323864 GenBank AGD02014.1 456 Sequence 3 from patent US 8338155
GI:6323864 GenBank EWG84124.1 443 Erg12p [Saccharomyces cerevisiae R008]
GI:6323864 GenBank EWG89476.1 443 Erg12p [Saccharomyces cerevisiae P301]
GI:6323864 GenBank EWG94142.1 443 Erg12p [Saccharomyces cerevisiae R103]
GI:6323864 GenBank EWH16799.1 443 Erg12p [Saccharomyces cerevisiae P283]
GI:6323864 gnl McCuskerlabDuke 443 Erg12p [Saccharomyces cerevisiae YJM993]