Gene/Proteome Database (LMPD)
Proteins
| oligo-1,6-glucosidase IMA1 | |
|---|---|
| Refseq ID | NP_011803 |
| Protein GI | 398366423 |
| UniProt ID | P53051 |
| mRNA ID | NM_001181416 |
| Length | 589 |
| RefSeq Status | PROVISIONAL |
| MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE | |
Gene Information
Entrez Gene ID
Gene Name
oligo-1,6-glucosidase IMA1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0043169 | IEA:InterPro | F | cation binding |
| GO:0004574 | IDA:SGD | F | oligo-1,6-glucosidase activity |
| GO:0004575 | IDA:SGD | F | sucrose alpha-glucosidase activity |
| GO:0046352 | IMP:SGD | P | disaccharide catabolic process |
| GO:0000023 | IEA:UniProtKB-KW | P | maltose metabolic process |
KEGG Pathway Links
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| GLYCOCAT-PWY | glycogen degradation |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5618460 | Amino acid transport across the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR017853 | Glycoside hydrolase superfamily |
| IPR013781 | Glycoside hydrolase, catalytic domain |
| IPR015902 | Glycoside hydrolase, family 13 |
| IPR013780 | Glycosyl hydrolase, family 13, all-beta |
| IPR006047 | Glycosyl hydrolase, family 13, catalytic domain |
| IPR006589 | Glycosyl hydrolase, family 13, subfamily, catalytic domain |
UniProt Annotations
Entry Information
Gene Name
oligo-1,6-glucosidase IMA1
Protein Entry
MALX3_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. |
| Function | Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization. Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose. {ECO:0000269|PubMed:15291818, ECO:0000269|PubMed:20562106}. |
| Induction | Expression is increased in response to the addition of maltose, isomaltose, and alpha-methylglucopyranoside. {ECO:0000269|PubMed:20562106}. |
| Interaction | P39940:RSP5; NbExp=2; IntAct=EBI-10464, EBI-16219; |
| Miscellaneous | Present with 752 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity | Belongs to the glycosyl hydrolase 13 family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:14576278, ECO:0000269|PubMed:16823961}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007436 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 398366423 | RefSeq | NP_011803 | 589 | oligo-1,6-glucosidase IMA1 |
Identical Sequences to LMP007436 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398366423 | EMBL | CBU98949.1 | 589 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:398366423 | GenBank | ADK27710.1 | 589 | alpha 1,6-glucosidase [Saccharomyces cerevisiae] |
| GI:398366423 | GenBank | EIW10693.1 | 589 | Ima1p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:398366423 | GenBank | AGX66529.1 | 589 | Sequence 33045 from patent US 8541208 |
| GI:398366423 | PDB | 3A4A | 589 | Chain A, Crystal Structure Of Isomaltase From Saccharomyces Cerevisiae |
| GI:398366423 | PDB | 3AJ7 | 589 | Chain A, Crystal Structure Of Isomaltase From Saccharomyces Cerevisiae |
Related Sequences to LMP007436 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:398366423 | DBBJ | BAD00094.1 | 589 | oligo-1,6-glucosidase [Saccharomyces cerevisiae] |
| GI:398366423 | EMBL | CBL86015.1 | 589 | unnamed protein product [Saccharomyces cerevisiae] |
| GI:398366423 | EMBL | CCA60749.1 | 589 | major isomaltase (alpha-1,6-glucosidase) [Saccharomyces carlsbergensis] |
| GI:398366423 | GenBank | EDZ71863.1 | 589 | YGR287Cp-like protein [Saccharomyces cerevisiae AWRI1631] |
| GI:398366423 | PDB | 3AXH | 589 | Chain A, Crystal Structure Of Isomaltase In Complex With Isomaltose |
| GI:398366423 | PDB | 3AXI | 589 | Chain A, Crystal Structure Of Isomaltase In Complex With Maltose |