Gene/Proteome Database (LMPD)

LMPD ID
LMP007454
Gene ID
851788
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ume6p
Gene Symbol
UME6
Synonyms
CAR80; NIM2; RIM16
Alternate Names
Ume6p
Chromosome
IV

Proteins

Ume6p
Refseq ID NP_010493
Protein GI 6320413
UniProt ID P39001
mRNA ID NM_001180515
Length 836
RefSeq Status PROVISIONAL
MLDKARSQSKHMDESNAAASLLSMETTANNHHYLHNKTSRATLMNSSQDGKKHAEDEVSDGANSRHPTISSASIESLKTTYDENPLLSIMKSTCAPNNTPVHTPSGSPSLKVQSGGDIKDDPKENDTTTTTNTTLQDRRDSDNAVHAAASPLAPSNTPSDPKSLCNGHVAQATDPQISGAIQPQYTATNEDVFPYSSTSTNSNTATTTIVAGAKKKIHLPPPQAPAVSSPGTTAAGSGAGTGSGIRSRTGSDLPLIITSANKNNGKTTNSPMSILSRNNSTNNNDNNSIQSSDSRESSNNNEIGGYLRGGTKRGGSPSNDSQVQHNVHDDQCAVGVAPRNFYFNKDREITDPNVKLDENESKINISFWLNSKYRDEAYSLNESSSNNASSNTDTPTNSRHANTSSSITSRNNFQHFRFNQIPSQPPTSASSFTSTNNNNPQRNNINRGEDPFATSSRPSTGFFYGDLPNRNNRNSPFHTNEQYIPPPPPKYINSKLDGLRSRLLLGPNSASSSTKLDDDLGTAAAVLSNMRSSPYRTHDKPISNVNDMNNTNALGVPASRPHSSSFPSKGVLRPILLRIHNSEQQPIFESNNSTAVFDEDQDQNQDLSPYHLNLNSKKVLDPTFESRTRQVTWNKNGKRIDRRLSAPEQQQQLEVPPLKKSRRSVGNARVASQTNSDYNSLGESSTSSAPSSPSLKASSGLAYTADYPNATSPDFAKSKGKNVKPKAKSKAKQSSKKRPNNTTSKSKANNSQESNNATSSTSQGTRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYDAFKPDFVSDPKKKQMKLEEIKKKTKEAKRRAMKKK

Gene Information

Entrez Gene ID
851788
Gene Name
Ume6p
Gene Symbol
UME6
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0033698 IDA:SGD C Rpd3L complex
GO:0000978 IDA:SGD F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IDA:SGD F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0070491 IDA:SGD F repressing transcription factor binding
GO:0000989 IGI:SGD F transcription factor binding transcription factor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006338 IMP:SGD P chromatin remodeling
GO:0034389 IMP:SGD P lipid particle organization
GO:1900471 IMP:SGD P negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter
GO:0010674 IMP:SGD P negative regulation of transcription from RNA polymerase II promoter during meiosis
GO:0007070 IMP:SGD P negative regulation of transcription from RNA polymerase II promoter during mitosis
GO:0001081 IMP:SGD P nitrogen catabolite repression of transcription from RNA polymerase II promoter
GO:1900475 IMP:SGD P positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter
GO:1900476 IMP:SGD P positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter
GO:1900472 IMP:SGD P positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
GO:1900525 IMP:SGD P positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter
GO:0010673 IMP:SGD P positive regulation of transcription from RNA polymerase II promoter during meiosis
GO:0007124 IMP:SGD P pseudohyphal growth
GO:0009847 IMP:SGD P spore germination

KEGG Pathway Links

KEGG Pathway ID Description
ko04113 Meiosis - yeast
sce04113 Meiosis - yeast

Domain Information

InterPro Annotations

Accession Description
IPR001138 Zn(2)-C6 fungal-type DNA-binding domain

UniProt Annotations

Entry Information

Gene Name
Ume6p
Protein Entry
UME6_YEAST
UniProt ID
P39001
Species
Yeast (S288c)

Comments

Comment Type Description
Function Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Binds to the URS1 site (5'- AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. Associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. Has both a positive and negative role in regulating phospholipid biosynthesis. {ECO:0000269|PubMed:10891485, ECO:0000269|PubMed:10931932, ECO:0000269|PubMed:11081629, ECO:0000269|PubMed:11238941, ECO:0000269|PubMed:12370439, ECO:0000269|PubMed:12693549, ECO:0000269|PubMed:12799429, ECO:0000269|PubMed:1579492, ECO:0000269|PubMed:15837806, ECO:0000269|PubMed:1592244, ECO:0000269|PubMed:2690066, ECO:0000269|PubMed:7760793, ECO:0000269|PubMed:7926768, ECO:0000269|PubMed:8614637, ECO:0000269|PubMed:8618927, ECO:0000269|PubMed:8628320, ECO:0000269|PubMed:9150136, ECO:0000269|PubMed:9343383, ECO:0000269|PubMed:9372955, ECO:0000269|PubMed:9572144, ECO:0000269|PubMed:9710596}.
Miscellaneous Present with 217 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Phosphorylated by RIM11 and MCK1. {ECO:0000269|PubMed:10891485, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198, ECO:0000269|PubMed:9372955}.
Similarity Contains 1 Zn(2)-C6 fungal-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00227}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
Subunit Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6. Interacts with RIM11, MCK1 and IME1. {ECO:0000269|PubMed:10891485, ECO:0000269|PubMed:11238941, ECO:0000269|PubMed:16314178, ECO:0000269|PubMed:8628320, ECO:0000269|PubMed:9150136, ECO:0000269|PubMed:9372955}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007454 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6320413 RefSeq NP_010493 836 Ume6p

Identical Sequences to LMP007454 proteins

Reference Database Accession Length Protein Name
GI:6320413 EMBL CAA92346.1 836 Nim2p [Saccharomyces cerevisiae]
GI:6320413 GenBank AAC14472.1 836 transcriptional regulator [Saccharomyces cerevisiae]
GI:6320413 GenBank AAV19913.1 836 Sequence 173 from patent US 6753314
GI:6320413 GenBank EIW11414.1 836 Ume6p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6320413 SwissProt P39001.2 836 RecName: Full=Transcriptional regulatory protein UME6; AltName: Full=Negative transcriptional regulator of IME2; AltName: Full=Regulator of inducer of meiosis protein 16; AltName: Full=Unscheduled meiotic gene expression protein 6 [Saccharomyces cerevisiae S288c]
GI:6320413 Third Party Genbank DAA12048.1 836 TPA: Ume6p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007454 proteins

Reference Database Accession Length Protein Name
GI:6320413 DBBJ BAA04890.1 836 NIM2 protein [Saccharomyces cerevisiae]
GI:6320413 DBBJ GAA22436.1 836 K7_Ume6p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6320413 GenBank EDN60544.1 836 C6 zinc finger URS1-binding protein [Saccharomyces cerevisiae YJM789]
GI:6320413 GenBank EDV08107.1 836 transcriptional regulator UME6 [Saccharomyces cerevisiae RM11-1a]
GI:6320413 GenBank EEU07829.1 836 Ume6p [Saccharomyces cerevisiae JAY291]
GI:6320413 gnl McCuskerlabDuke 836 Ume6p [Saccharomyces cerevisiae YJM993]