Gene/Proteome Database (LMPD)
Proteins
| tetrafunctional fatty acid synthase subunit FAS1 | |
|---|---|
| Refseq ID | NP_012739 |
| Protein GI | 6322666 |
| UniProt ID | P07149 |
| mRNA ID | NM_001179748 |
| Length | 2051 |
| MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNKSGKIFVETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEKGSTFGINLIYVNPFMLQWGIPLIKELRSKGYPIQFLTIGAGVPSLEVASEYIETLGLKYLGLKPGSIDAISQVINIAKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNIMLIFGSGFGSADDTYPYLTGEWSTKFDYPPMPFDGFLFGSRVMIAKEVKTSPDAKKCIAACTGVPDDKWEQTYKKPTGGIVTVRSEMGEPIHKIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLNADFQKPWFATVNGQARDLATMTYEEVAKRLVELMFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDVQSQVDSSSVSEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKENVKVARLAGKYIPNLTAKPFQVTKEYFQDVYDLTGSEPIKEIIDNWEKYEQS | |
Gene Information
Entrez Gene ID
Gene Name
tetrafunctional fatty acid synthase subunit FAS1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:SGD | C | cytosol |
| GO:0005835 | IDA:SGD | C | fatty acid synthase complex |
| GO:0005811 | IDA:SGD | C | lipid particle |
| GO:0019171 | IDA:SGD | F | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| GO:0047451 | IEA:UniProtKB-EC | F | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity |
| GO:0004313 | IDA:SGD | F | [acyl-carrier-protein] S-acetyltransferase activity |
| GO:0004314 | IDA:SGD | F | [acyl-carrier-protein] S-malonyltransferase activity |
| GO:0004318 | IEA:UniProtKB-EC | F | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| GO:0004319 | IDA:SGD | F | enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity |
| GO:0004321 | IEA:UniProtKB-EC | F | fatty-acyl-CoA synthase activity |
| GO:0016295 | IEA:UniProtKB-EC | F | myristoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0004320 | IEA:UniProtKB-EC | F | oleoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0016296 | IEA:UniProtKB-EC | F | palmitoyl-[acyl-carrier-protein] hydrolase activity |
| GO:0016409 | IDA:SGD | F | palmitoyltransferase activity |
| GO:0042759 | IMP:SGD | P | long-chain fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00061 | Fatty acid biosynthesis |
| sce00061 | Fatty acid biosynthesis |
| M00083 | Fatty acid biosynthesis, elongation |
| sce_M00083 | Fatty acid biosynthesis, elongation |
| M00082 | Fatty acid biosynthesis, initiation |
| sce_M00082 | Fatty acid biosynthesis, initiation |
| ko01212 | Fatty acid metabolism |
| sce01212 | Fatty acid metabolism |
| sce01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-5966 | fatty acid biosynthesis initiation |
| PWY-5966 | fatty acid biosynthesis initiation II |
| FASYN-ELONG2-PWY | fatty acid elongation |
| FASYN-ELONG-PWY-1 | fatty acid elongation -- saturated |
| PWY-5994 | palmitate biosynthesis |
| PWY-5994 | palmitate biosynthesis I (animals and fungi) |
| PWY3O-355 | stearate biosynthesis |
| PWY3O-355 | stearate biosynthesis III (fungi) |
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
tetrafunctional fatty acid synthase subunit FAS1
Protein Entry
FAS1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. |
| Catalytic Activity | Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]. |
| Catalytic Activity | Acetyl-CoA + n malonyl-CoA + 2n NADPH = long- chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+). |
| Catalytic Activity | An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH. |
| Catalytic Activity | Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]. |
| Catalytic Activity | Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate. |
| Function | Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. |
| Interaction | P19097:FAS2; NbExp=3; IntAct=EBI-6795, EBI-6806; |
| Miscellaneous | Present with 91800 molecules/cell in log phase SD medium |
| Miscellaneous | Present with 91800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Sequence Caution | Sequence=CAA27616.1; Type=Frameshift; Positions=1845, 1948, 2017; Evidence= ; |
| Sequence Caution | Sequence=CAA27616.1; Type=Frameshift; Positions=1845, 1948, 2017; Evidence={ECO:0000305}; |
| Similarity | Belongs to the fungal fatty acid synthetase subunit beta family |
| Similarity | Belongs to the fungal fatty acid synthetase subunit beta family. {ECO:0000305}. |
| Similarity | Contains 1 MaoC-like domain |
| Similarity | Contains 1 MaoC-like domain. {ECO:0000305}. |
| Subunit | [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta). |
Identical and Related Proteins
Unique RefSeq proteins for LMP007458 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6322666 | RefSeq | NP_012739 | 2051 | tetrafunctional fatty acid synthase subunit FAS1 |
Identical Sequences to LMP007458 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP007458 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|