LIPID MAPS

LMPD ID

LMP007466

Gene ID

852989

Species

Saccharomyces cerevisiae S288c (Yeast (S288c))

Gene Name

Ask10p

Gene Symbol

ASK10

Synonyms

RGC2

Chromosome

VII

Ask10p
Refseq ID	NP_011611
Protein GI	6321534
UniProt ID	P48361
mRNA ID	NM_001181226
Length	1146
MSDYFSSRPSQTLTPMGNKPSGGGGGDDASSIHSKSSQYLMDILPDSMTLNESVSSIVANNQAKEFILPETDERSPYFINVPIPKAQPTSTTETKKPLAGDEAIDGQFVKEYPTDILVDRFYKWKKILKGLVIYLREVAYAQEQFARINYQLKGSVKFPFLTDIDETTNTITDPFTTAPRGPKKAQPAQKKVGLTDSEQFQMQMQQEQQENAVQAPTDESKMSLAPHEYKPVQTTESDNTSAASGFVKFGSGSIQDIQVILKKYHLSLANQQFKISKEITSTVIPKLEELRKDLRYKITEIKDLHGDFKTNIGAHIQLTSQLLKKYIAAVKFMNAHGIGNDRASPTNKKPHKLDPKHDPYLLKLQLDLQLKRQVAEETYLQEAFINLQSSGLQLEKIIYTKIQHALLRYSALIDSEARLMIKNMCQELQHGIISKPPAFEWDNFVTQHPSCLLNWKSNDPIPPPRKVSDVIYPHMKSPLAKCIKAGYFLKKSELLPTYHQGYFVLTSNYIHEFQSSDFYNLSSSTPNSTKSSAYSSSVSIADTYANANNAKANNHHRQASDVHNSSTTTGGTAGANGIRGIRKKSYLAPIMSIPLNDCTLKDASSTKFVLVGKPTLNENADVRKSSSSTYLSGSSQASLPKYGHETAKIFSKAPFHKFLKGSKPKNKNTKSSELDQFYAAAQKESNNYVTWTFKIVSPEPSEEELKHFKRWVQDLKNLTSFNDTKDRIKFIEDRVMKSHRFKAGHMSRNSVNIGSHTPCLTDSTFTLQDGTTTSVNLKGRAEKPQYIHIQNNSLADFDGNGFRSKVNTPAIDDYGNLITVERRPAQSPHQYSDYMATSGNTTPSYSSGSRPQSMYNGYNPAVSITSNGMMLQQSTANNNTNPTTNLRHQRNISQTSSLPGFSYTSLSLPVNSPGSSNSESSSGGYFAIPLHGNNNNNNYTQRNSEGSSPCYNDDQIRQQQQPLQMQPLSRTSSSSVNVTAMRSTSAGNSITANAPVVPKVMVNNQNVKTVAADQSATAPSSPTMNSSVTTINRESPYQTLKKTNSTGNVPCLTAEKTHAHPAFYKRGNNSAQNLTTSSSTASRVHPIRKHKKNVSFSSLNSLMFSKKGANHGGNLMTNQFMSGGIQEDDGDSTNNDTIKLNQSIYS

Entrez Gene ID

852989

Gene Name

Ask10p

Gene Symbol

ASK10

Species

Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016591	IDA:SGD	C	DNA-directed RNA polymerase II, holoenzyme
GO:0005737	IDA:SGD	C	cytoplasm
GO:0044257	IMP:SGD	P	cellular protein catabolic process
GO:0034599	IMP:SGD	P	cellular response to oxidative stress
GO:0090372	IMP:SGD	P	positive regulation of glycerol transport
GO:0045944	IMP:SGD	P	positive regulation of transcription from RNA polymerase II promoter

InterPro Annotations

Accession	Description
IPR001849	Pleckstrin homology domain
IPR011993	Pleckstrin homology-like domain

Entry Information

Gene Name

Ask10p

Protein Entry

ASK10_YEAST

UniProt ID

P48361

Species

Yeast (S288c)

Comments

Comment Type	Description
Function	Positive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8
Function	Positive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8. {ECO:0000269\|PubMed:14555478, ECO:0000269\|PubMed:19956799}.
Ptm	Phosphorylated in response to various stresses. stress- induced phosphorylation is partially dependent on HOG1. {ECO:0000269\|PubMed:14555478, ECO:0000269\|PubMed:17287358, ECO:0000269\|PubMed:17330950, ECO:0000269\|PubMed:18407956, ECO:0000269\|PubMed:19779198, ECO:0000269\|PubMed:19956799}.
Similarity	Belongs to the RGC1 family
Similarity	Belongs to the RGC1 family. {ECO:0000305}.
Similarity	Contains 1 PH domain
Similarity	Contains 1 PH domain. {ECO:0000305}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:14562095, ECO:0000269\|PubMed:19956799}. Note=Displays diffuse cytoplasmic localization, but very rapidly aggregates into punctate spots that appear near the cell surface in response to hypo-osmotic shock.
Subunit	Component of the RNA polymerase II holoenzyme. Interacts with RPO21 and SSN8
Subunit	Component of the RNA polymerase II holoenzyme. Interacts with RPO21 and SSN8. {ECO:0000269\|PubMed:14555478}.