Gene/Proteome Database (LMPD)
Proteins
| hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 | |
|---|---|
| Refseq ID | NP_013636 |
| Protein GI | 6323565 |
| UniProt ID | P12683 |
| mRNA ID | NM_001182434 |
| Length | 1054 |
| RefSeq Status | PROVISIONAL |
| MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSVIQYYFNGWQLDSNSVFETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPHHYYLLNLNFNSPNETDSIPELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSDRKSLFDVKTLAYSLYDVFSENVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQCILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTDEIVFESVSEEGGRLIQDHLLCIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALRLEMNVIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLFVFINFYNFGANWVNDAFNSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKSYQRIEDMVLLLLRNVSVAIRDRFVSKLVLSALVCSAVINVYLLNAARIHTSYTADQLVKTEVTKKSFTAPVQKASTPVLTNKTVISGSKVKSLSSAQSSSSGPSSSSEEDDSRDIESLDKKIRPLEELEALLSSGNTKQLKNKEVAALVIHGKLPLYALEKKLGDTTRAVAVRRKALSILAEAPVLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLVGSAMAGSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGHLVQSHMTHNRKPAEPTKPNNLDATDINRLKDGSVTCIKS | |
Gene Information
Entrez Gene ID
Gene Name
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IDA:SGD | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005635 | IDA:SGD | C | nuclear envelope |
| GO:0050661 | IEA:InterPro | F | NADP binding |
| GO:0004420 | IDA:SGD | F | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| GO:0015936 | IEA:InterPro | P | coenzyme A metabolic process |
| GO:0006696 | IMP:SGD | P | ergosterol biosynthetic process |
| GO:0019287 | IC:SGD | P | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce_M00095 | C5 isoprenoid biosynthesis, mevalonate pathway |
| sce00900 | Terpenoid backbone biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR025583 | HMG-CoA reductase, N-terminal domain |
| IPR023282 | Hydroxymethylglutaryl-CoA reductase, N-terminal |
| IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II |
| IPR009023 | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain |
| IPR023074 | Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain |
| IPR023076 | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site |
| IPR009029 | Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain |
| IPR004554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type |
| IPR000731 | Sterol-sensing domain |
UniProt Annotations
Entry Information
Gene Name
hydroxymethylglutaryl-CoA reductase (NADPH) HMG1
Protein Entry
HMDH1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH. {ECO:0000255|PROSITE- ProRule:PRU10003}. |
| Function | One of 2 isozymes that catalyze the conversion of HMG- CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis. {ECO:0000269|PubMed:3526336, ECO:0000269|PubMed:9292983}. |
| Interaction | P12684:HMG2; NbExp=3; IntAct=EBI-8377, EBI-8384; |
| Pathway | Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. |
| Similarity | Belongs to the HMG-CoA reductase family. {ECO:0000305}. |
| Similarity | Contains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007493 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6323565 | RefSeq | NP_013636 | 1054 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 |
Identical Sequences to LMP007493 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323565 | GenBank | ABZ27911.1 | 1054 | Sequence 1849 from patent US 7314974 |
| GI:6323565 | GenBank | ACP76210.1 | 1054 | Sequence 8 from patent US 7501268 |
| GI:6323565 | GenBank | ACP76212.1 | 1054 | Sequence 12 from patent US 7501268 |
| GI:6323565 | GenBank | AFX58119.1 | 1054 | Sequence 50 from patent US 8309323 |
| GI:6323565 | GenBank | AFX58160.1 | 1054 | Sequence 155 from patent US 8309323 |
| GI:6323565 | Third Party Genbank | DAA09822.1 | 1054 | TPA: hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007493 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6323565 | DBBJ | GAA25373.1 | 1054 | K7_Hmg1p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6323565 | GenBank | EDV11434.1 | 1054 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase isozyme [Saccharomyces cerevisiae RM11-1a] |
| GI:6323565 | GenBank | EIW08607.1 | 1054 | Hmg1p [Saccharomyces cerevisiae CEN.PK113-7D] |
| GI:6323565 | GenBank | EWG89240.1 | 1054 | Hmg1p [Saccharomyces cerevisiae P301] |
| GI:6323565 | GenBank | EWH16565.1 | 1054 | Hmg1p [Saccharomyces cerevisiae P283] |
| GI:6323565 | gnl | McCuskerlabDuke | 1054 | Hmg1p [Saccharomyces cerevisiae YJM993] |