Gene/Proteome Database (LMPD)

LMPD ID
LMP007503
Gene ID
850903
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Ent2p
Gene Symbol
ENT2
Synonyms
-
Alternate Names
Ent2p
Chromosome
XII

Proteins

Ent2p
Refseq ID NP_013307
Protein GI 6323235
UniProt ID Q05785
mRNA ID NM_001182093
Length 613
RefSeq Status PROVISIONAL
MSKQFVRSAKNMMKGYSSTQVLVRDATANDSRTPSIDTLDDLAQRSYDSVDFFEIMDMLDKRLNDKGKYWRHVAKSLTVLDYLVRFGSENCVLWCRENFYVIKTLREFRHENESGFDEGQIIRVKAKELVSLLNDEERLREERSMNTRNRRANRAARPRPRRQRTRSNPHDSSPSYQDDLEKALEESRITAQEDEQRRRELAQYDDEDPDFQAALQLSKEEEELKQLQELQRLQKQQQSLSQFQAPLQQQQPQQQPAYYDIFGNPISQDEYLQYQYQQDQEQAMAQQRWLDQQQEQQQLAEQQYFQQQQQAAAAASALQQQQTAANMQQQQQQPADFQQPLPTGSNNPFSMDNLERQKQEQQHAQLQRQQEEARQQQEQLKLQQLQRQQQEEAQLHQKRQEEAQLQQQQAQLLQQQAQFQQQQPLKQTRTGNQSISDKYSDLNTLLATGTGIDTFGNTGEARIPAQHTKTGTFINSQGTGYKQVTNEPKNNPFLSNQYTGLPSTNIVPTQTGYGFGNQPQSPPTNSPQQNPTGISYSQPQQQQQPQQQPQYMQNFQQQQPQYAQNFQQQPQYTQNYQQQPQYIQPHQQQQQQQQQQQQQQGYTPDQGVSLIDL

Gene Information

Entrez Gene ID
850903
Gene Name
Ent2p
Gene Symbol
ENT2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030479 TAS:SGD C actin cortical patch
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0030276 TAS:SGD F clathrin binding
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0000147 IMP:SGD P actin cortical patch assembly
GO:0007015 IMP:SGD P actin filament organization
GO:0006897 IMP:SGD P endocytosis

KEGG Pathway Links

KEGG Pathway ID Description
ko04144 Endocytosis
sce04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR008942 ENTH_VHS
IPR013809 Epsin-like_N
IPR003903 Ubiquitin interacting motif

UniProt Annotations

Entry Information

Gene Name
Ent2p
Protein Entry
ENT2_YEAST
UniProt ID
Q05785
Species
Yeast (S288c)

Comments

Comment Type Description
Function Binds to membranes enriched in phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. {ECO:0000269|PubMed:10449404}.
Miscellaneous Present with 1970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Phosphorylated by PRK1. {ECO:0000269|PubMed:11694597, ECO:0000269|PubMed:17287358, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}.
Similarity Belongs to the epsin family. {ECO:0000305}.
Similarity Contains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00243}.
Similarity Contains 2 UIM (ubiquitin-interacting motif) repeats. {ECO:0000255|PROSITE-ProRule:PRU00213}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=Localizes in a punctate pattern. Found in the actin cortical patches, although the majority is located at the cell periphery.

Identical and Related Proteins

Unique RefSeq proteins for LMP007503 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323235 RefSeq NP_013307 613 Ent2p

Identical Sequences to LMP007503 proteins

Reference Database Accession Length Protein Name
GI:6323235 GenBank AAB67428.1 613 Ylr206wp [Saccharomyces cerevisiae]
GI:6323235 GenBank ABJ38074.1 613 Sequence 278 from patent US 7101990
GI:6323235 GenBank EIW08813.1 613 Ent2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323235 SwissProt Q05785.1 613 RecName: Full=Epsin-2 [Saccharomyces cerevisiae S288c]
GI:6323235 Third Party Genbank DAA09523.1 613 TPA: Ent2p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007503 proteins

Reference Database Accession Length Protein Name
GI:6323235 GenBank EDN59427.1 616 epsin-like protein [Saccharomyces cerevisiae YJM789]
GI:6323235 GenBank EDV08539.1 614 epsin-2 [Saccharomyces cerevisiae RM11-1a]
GI:6323235 GenBank EEU09240.1 615 Ent2p [Saccharomyces cerevisiae JAY291]
GI:6323235 GenBank EGA57645.1 648 Ent2p [Saccharomyces cerevisiae FostersB]
GI:6323235 GenBank EGA73744.1 615 Ent2p [Saccharomyces cerevisiae AWRI796]
GI:6323235 GenBank EWG84448.1 616 Ent2p [Saccharomyces cerevisiae R008]