Gene/Proteome Database (LMPD)

LMPD ID
LMP007508
Gene ID
852522
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Gene Symbol
PDB1
Synonyms
-
Alternate Names
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Chromosome
II
EC Number
1.2.4.1

Proteins

pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Refseq ID NP_009780
Protein GI 6319698
UniProt ID P32473
mRNA ID NM_001178569
Length 366
RefSeq Status PROVISIONAL
MFSRLPTSLARNVARRAPTSFVRPSAAAAALRFSSTKTMTVREALNSAMAEELDRDDDVFLIGEEVAQYNGAYKVSKGLLDRFGERRVVDTPITEYGFTGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQMVFRGPNGAAVGVGAQHSQDFSPWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYGESFEISEEALSPEFTLPYKAKIEREGTDISIVTYTRNVQFSLEAAEILQKKYGVSAEVINLRSIRPLDTEAIIKTVKKTNHLITVESTFPSFGVGAEIVAQVMESEAFDYLDAPIQRVTGADVPTPYAKELEDFAFPDTPTIVKAVKEVLSIE

Gene Information

Entrez Gene ID
852522
Gene Name
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Gene Symbol
PDB1
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042645 IDA:SGD C mitochondrial nucleoid
GO:0005967 IDA:SGD C mitochondrial pyruvate dehydrogenase complex
GO:0005739 IMP:SGD C mitochondrion
GO:0004739 IMP:SGD F pyruvate dehydrogenase (acetyl-transferring) activity
GO:0006086 IDA:SGD P acetyl-CoA biosynthetic process from pyruvate
GO:0006096 IEA:UniProtKB-KW P glycolytic process

KEGG Pathway Links

KEGG Pathway ID Description
sce01200 Carbon metabolism
sce00020 Citrate cycle (TCA cycle)
sce00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR027110 Pyruvate dehydrogenase E1 component subunit beta
IPR029061 Thiamin diphosphate-binding fold
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR005475 Transketolase-like, pyrimidine-binding domain

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Protein Entry
ODPB_YEAST
UniProt ID
P32473
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Miscellaneous Present with 9970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Subcellular Location Mitochondrion matrix.
Subunit Pyruvate dehydrogenase (E1) is a tetramer of 2 alpha and 2 beta subunits. Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.

Identical and Related Proteins

Unique RefSeq proteins for LMP007508 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6319698 RefSeq NP_009780 366 pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta

Identical Sequences to LMP007508 proteins

Reference Database Accession Length Protein Name
GI:6319698 GenBank AEU53524.1 366 Sequence 155 from patent US 8062891
GI:6319698 GenBank AGO72477.1 366 Sequence 155 from patent US 8470972
GI:6319698 GenBank AGP21931.1 366 Sequence 58 from patent US 8465964
GI:6319698 GenBank AGU32468.1 366 Sequence 155 from patent US 8507277
GI:6319698 GenBank AGX48372.1 366 Sequence 155 from patent US 8541550
GI:6319698 GenBank AIB02137.1 366 Sequence 85 from patent US 8669094

Related Sequences to LMP007508 proteins

Reference Database Accession Length Protein Name
GI:6319698 GenBank AAA34583.1 366 pyruvate dehydrogenase E1-beta subunit [Saccharomyces cerevisiae]
GI:6319698 GenBank AAW00665.1 366 Sequence 46 from patent US 6773917
GI:6319698 GenBank EWG87787.1 366 Pdb1p [Saccharomyces cerevisiae R008]
GI:6319698 GenBank EWG92553.1 366 Pdb1p [Saccharomyces cerevisiae P301]
GI:6319698 GenBank EWG97413.1 366 Pdb1p [Saccharomyces cerevisiae R103]
GI:6319698 GenBank EWH19597.1 366 Pdb1p [Saccharomyces cerevisiae P283]