Gene/Proteome Database (LMPD)

LMPD ID
LMP007517
Gene ID
850432
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Atg15p
Gene Symbol
ATG15
Synonyms
AUT5; CVT17
Alternate Names
Atg15p
Chromosome
III
EC Number
3.1.1.3

Proteins

Atg15p
Refseq ID NP_009994
Protein GI 10383802
UniProt ID P25641
mRNA ID NM_001178779
Length 520
RefSeq Status PROVISIONAL
MLHKSPSRKRFASPLHLGCILTLTVLCLIAYYFALPDYLSVGKSSSRGAMDQKSDGTFRLKSIYRHGVGANHRLHQRLEVTPEVISAAGMLYQETTTQGQDFEDQEPLWTTNAEYATTNPFDFEFELRRMPLLMKRMKERDPEFIESYIYGETYMTEEEEHAMWIDDDIVAPNITDRGTVVSLALMSSNAYVRIPQTGDWRNVTEPWNETEPEDFGWDGDGIRGHVFYNEVENIVVLSIKGTSAQGLPGSGEDETTGNDKINDNLLFSCCCARVSYLWTTVCDCYVKSYICDESCLEKELRRKDRFYSAVVDIYKGVLKEYPDAAIWVTGHSLGGALASLLGRTFGLPAVAFESPGELLPSKRLHLPFPPGLPSYMEGIWHFGHNADPIFMGTCNGASSSCSLVGYAMETACHTGRVCVYDVVNDKGWSVNMFNHRIHKVIDEVLLGYEQAAKCVEPEPCVDCYNWKFIPSRDWESSSRLITKTKSHAAPTTTTRTTATTTSSSTCVGRNWLGFCTKYEL

Gene Information

Entrez Gene ID
850432
Gene Name
Atg15p
Gene Symbol
ATG15
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0016021 IDA:UniProtKB C integral component of membrane
GO:0005775 IDA:UniProtKB C vacuolar lumen
GO:0004806 IEA:UniProtKB-EC F triglyceride lipase activity
GO:0006914 IDA:UniProtKB P autophagy
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0030397 IDA:UniProtKB P membrane disassembly
GO:0034496 IMP:SGD P multivesicular body membrane disassembly
GO:0034727 IMP:SGD P piecemeal microautophagy of nucleus
GO:0006624 IDA:UniProtKB P vacuolar protein processing

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
sce00561 Glycerolipid metabolism
sce01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
LIPAS-PWY triacylglycerol degradation

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002921 Fungal lipase-like domain

UniProt Annotations

Entry Information

Gene Name
Atg15p
Protein Entry
ATG15_YEAST
UniProt ID
P25641
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension. {ECO:0000269|PubMed:11085977, ECO:0000269|PubMed:11264288, ECO:0000269|PubMed:11566994, ECO:0000269|PubMed:12499386, ECO:0000269|PubMed:18690010, ECO:0000269|PubMed:21364763, ECO:0000269|PubMed:21777356}.
Miscellaneous Present with 3060 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Ptm Glycosylated. {ECO:0000269|PubMed:11085977, ECO:0000269|PubMed:11566994, ECO:0000269|PubMed:12499386}.
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Subunit Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).

Identical and Related Proteins

Unique RefSeq proteins for LMP007517 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10383802 RefSeq NP_009994 520 Atg15p

Identical Sequences to LMP007517 proteins

Reference Database Accession Length Protein Name
GI:10383802 EMBL CAC42987.1 520 hypothetical protein [Saccharomyces cerevisiae]
GI:10383802 GenBank EIW11800.1 520 Atg15p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:10383802 GenBank AHN96127.1 520 ATG15 [synthetic construct]
GI:10383802 GenBank AHV79330.1 520 ATG15 [synthetic construct]
GI:10383802 SwissProt P25641.2 520 RecName: Full=Putative lipase ATG15; AltName: Full=Autophagy-related protein 15; AltName: Full=Cytoplasm to vacuole targeting protein 17 [Saccharomyces cerevisiae S288c]
GI:10383802 Third Party Genbank DAA07540.1 520 TPA: Atg15p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007517 proteins

Reference Database Accession Length Protein Name
GI:10383802 DBBJ GAA21971.1 520 K7_Atg15p [Saccharomyces cerevisiae Kyokai no. 7]
GI:10383802 EMBL CAY78272.1 520 Atg15p [Saccharomyces cerevisiae EC1118]
GI:10383802 GenBank EDN62181.1 520 autophagy-related protein [Saccharomyces cerevisiae YJM789]
GI:10383802 GenBank EGA75797.1 520 Atg15p [Saccharomyces cerevisiae AWRI796]
GI:10383802 GenBank EGA83765.1 520 Atg15p [Saccharomyces cerevisiae Lalvin QA23]
GI:10383802 SwissProt A6ZTP2.1 520 RecName: Full=Putative lipase ATG15; AltName: Full=Autophagy-related protein 15; AltName: Full=Cytoplasm to vacuole targeting protein 17 [Saccharomyces cerevisiae YJM789]