Gene/Proteome Database (LMPD)
LMPD ID
LMP007522
Gene ID
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
Gene Symbol
Synonyms
GAT2
Alternate Names
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
Chromosome
II
EC Number
2.3.1.15
Proteins
| bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 | |
|---|---|
| Refseq ID | NP_009542 |
| Protein GI | 6319459 |
| UniProt ID | P32784 |
| mRNA ID | NM_001178251 |
| Length | 759 |
| RefSeq Status | PROVISIONAL |
| MPAPKLTEKFASSKSTQKTTNYSSIEAKSVKTSADQAYIYQEPSATKKILYSIATWLLYNIFHCFFREIRGRGSFKVPQQGPVIFVAAPHANQFVDPVILMGEVKKSVNRRVSFLIAESSLKQPPIGFLASFFMAIGVVRPQDNLKPAEGTIRVDPTDYKRVIGHDTHFLTDCMPKGLIGLPKSMGFGEIQSIESDTSLTLRKEFKMAKPEIKTALLTGTTYKYAAKVDQSCVYHRVFEHLAHNNCIGIFPEGGSHDRTNLLPLKAGVAIMALGCMDKHPDVNVKIVPCGMNYFHPHKFRSRAVVEFGDPIEIPKELVAKYHNPETNRDAVKELLDTISKGLQSVTVTCSDYETLMVVQTIRRLYMTQFSTKLPLPLIVEMNRRMVKGYEFYRNDPKIADLTKDIMAYNAALRHYNLPDHLVEEAKVNFAKNLGLVFFRSIGLCILFSLAMPGIIMFSPVFILAKRISQEKARTALSKSTVKIKANDVIATWKILIGMGFAPLLYIFWSVLITYYLRHKPWNKIYVFSGSYISCVIVTYSALIVGDIGMDGFKSLRPLVLSLTSPKGLQKLQKDRRNLAERIIEVVNNFGSELFPDFDSAALREEFDVIDEEEEDRKTSELNRRKMLRKQKIKRQEKDSSSPIISQRDNHDAYEHHNQDSDGVSLVNSDNSLSNIPLFSSTFHRKSESSLASTSVAPSSSSEFEVENEILEEKNGLASKIAQAVLNKRIGENTAREEEEEEEEEEEEEEEEEEGKEGDA | |
Gene Information
Entrez Gene ID
Gene Name
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
Gene Symbol
Species
Saccharomyces cerevisiae S288c
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:SGD | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0004366 | IDA:SGD | F | glycerol-3-phosphate O-acyltransferase activity |
| GO:0016287 | IDA:SGD | F | glycerone-phosphate O-acyltransferase activity |
| GO:0016024 | IEA:UniProtKB-UniPathway | P | CDP-diacylglycerol biosynthetic process |
| GO:0008654 | IMP:SGD | P | phospholipid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| sce00564 | Glycerophospholipid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-7411 | superpathway phosphatidate biosynthesis (yeast) |
| TRIGLSYN-PWY | triacylglycerol biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002123 | Phospholipid/glycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
Protein Entry
GPT1_YEAST
UniProt ID
Species
Yeast (S288c)
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate. |
| Catalytic Activity | Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}. |
| Function | G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase. {ECO:0000269|PubMed:11544256}. |
| Miscellaneous | Present with 1050 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. |
| Similarity | Belongs to the GPAT/DAPAT family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007522 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6319459 | RefSeq | NP_009542 | 759 | bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 |
Identical Sequences to LMP007522 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6319459 | EMBL | CAA84831.1 | 759 | SCT1 [Saccharomyces cerevisiae] |
| GI:6319459 | SwissProt | P32784.3 | 759 | RecName: Full=Glycerol-3-phosphate O-acyltransferase 1; Short=G-3-P acyltransferase 1; AltName: Full=Dihydroxyacetone phosphate acyltransferase 1; Short=DHAP-AT 1; AltName: Full=Glycerol-3-phosphate / dihydroxyacetone phosphate acyltransferase 1; AltName: Full=Suppressor of choline-transport mutants 1 [Saccharomyces cerevisiae S288c] |
| GI:6319459 | Third Party Genbank | DAA07108.1 | 759 | TPA: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288c] |
Related Sequences to LMP007522 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6319459 | DBBJ | BAA07409.1 | 759 | SCT1 [Saccharomyces cerevisiae] |
| GI:6319459 | DBBJ | GAA21540.1 | 759 | K7_Sct1p [Saccharomyces cerevisiae Kyokai no. 7] |
| GI:6319459 | GenBank | EDV12103.1 | 754 | glycerol-3-phosphate O-acyltransferase 1 [Saccharomyces cerevisiae RM11-1a] |
| GI:6319459 | GenBank | EEU08111.1 | 754 | Sct1p [Saccharomyces cerevisiae JAY291] |
| GI:6319459 | GenBank | EGA88076.1 | 754 | Sct1p [Saccharomyces cerevisiae VL3] |
| GI:6319459 | GenBank | EIW12297.1 | 758 | Sct1p [Saccharomyces cerevisiae CEN.PK113-7D] |