Gene/Proteome Database (LMPD)

LMPD ID
LMP007523
Gene ID
854159
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
Pfa4p
Gene Symbol
PFA4
Synonyms
-
Alternate Names
Pfa4p
Chromosome
XV
EC Number
2.3.1.225

Proteins

Pfa4p
Refseq ID NP_014640
Protein GI 6324571
UniProt ID Q12006
mRNA ID NM_001183257
Length 378
RefSeq Status PROVISIONAL
MPVKLRWPWLGIAIPTFLISFIGYGAHYFILSNFLSVPKQITFEFCLSMIWLSYYLAICTNPGRPLPNYKPPPDIWRNFCKKCQSYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGFANYPHFLRFLFWIIVTTSVLFCIQAKRIYFIWQQRHLPGYFFKKSELIFLTISSPLNSFVLLTITILFLRCLFNQILNGRSQIESWDMDRLESLFNSGRLTQKLIDNTWRIYPESRSFQNKKDAEEHLTKKRPRFDELVNFPYDFDLYTNALLYLGPIHLWLWPYGVPTGDGNNFPKNGISKYEANSSLEDHILSLPWPPDGGKTNTVFNHGSSTIEMRNESGEQLIRTRLPQNGRHASREKWYNDWGESLDDFGVDVDME

Gene Information

Entrez Gene ID
854159
Gene Name
Pfa4p
Gene Symbol
PFA4
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:SGD C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016409 IDA:UniProt F palmitoyltransferase activity
GO:0019706 IEA:UniProtKB-EC F protein-cysteine S-palmitoyltransferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0018345 IDA:UniProt P protein palmitoylation

Domain Information

InterPro Annotations

Accession Description
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase

UniProt Annotations

Entry Information

Gene Name
Pfa4p
Protein Entry
PFA4_YEAST
UniProt ID
Q12006
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
Domain The DHHC domain is required for palmitoyltransferase activity. {ECO:0000250}.
Function Can palmitoylate RAS2 in vitro. {ECO:0000269|PubMed:12379641}.
Ptm Autopalmitoylated.
Similarity Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily. {ECO:0000305}.
Similarity Contains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15973437}; Multi-pass membrane protein {ECO:0000269|PubMed:15973437}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007523 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6324571 RefSeq NP_014640 378 Pfa4p

Identical Sequences to LMP007523 proteins

Reference Database Accession Length Protein Name
GI:6324571 GenBank EDN63868.1 378 palmitoyltransferase [Saccharomyces cerevisiae YJM789]
GI:6324571 GenBank EDV10606.1 378 palmitoyltransferase [Saccharomyces cerevisiae RM11-1a]
GI:6324571 GenBank EGA73128.1 378 Pfa4p [Saccharomyces cerevisiae AWRI796]
GI:6324571 GenBank EGA84910.1 378 Pfa4p [Saccharomyces cerevisiae VL3]
GI:6324571 GenBank EWG93457.1 378 Pfa4p [Saccharomyces cerevisiae R103]
GI:6324571 Third Party Genbank DAA10780.1 378 TPA: Pfa4p [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007523 proteins

Reference Database Accession Length Protein Name
GI:6324571 DBBJ GAA26321.1 378 K7_Pfa4p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6324571 GenBank EEU08924.1 378 Pfa4p [Saccharomyces cerevisiae JAY291]
GI:6324571 GenBank EGA76982.1 378 Pfa4p [Saccharomyces cerevisiae Vin13]
GI:6324571 GenBank EIW07432.1 378 Pfa4p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6324571 GenBank EWH15854.1 378 Pfa4p [Saccharomyces cerevisiae P283]
GI:6324571 gnl McCuskerlabDuke 378 Pfa4p [Saccharomyces cerevisiae YJM993]