Gene/Proteome Database (LMPD)

LMPD ID
LMP007531
Gene ID
851171
Species
Saccharomyces cerevisiae S288c (Yeast (S288c))
Gene Name
hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
Gene Symbol
HMG2
Synonyms
-
Alternate Names
hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
Chromosome
XII
EC Number
1.1.1.34

Proteins

hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
Refseq ID NP_013555
Protein GI 6323483
UniProt ID P12684
mRNA ID NM_001182338
Length 1045
RefSeq Status PROVISIONAL
MSLPLKTIVHLVKPFACTARFSARYPIHVIVVAVLLSAAAYLSVTQSYLNEWKLDSNQYSTYLSIKPDELFEKCTHYYRSPVSDTWKLLSSKEAADIYTPFHYYLSTISFQSKDNSTTLPSLDDVIYSVDHTRYLLSEEPKIPTELVSENGTKWRLRNNSNFILDLHNIYRNMVKQFSNKTSEFDQFDLFIILAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSLYTTHSLLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYEAMFQEGAYLIRDYLFYISSFIGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILSMKLEINIIHRSTVIRQTLEEDGVVPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLLLLINLYVFTDKLNATILNTVYFDSTIYSLPNFINYKDIGNLSNQVIISVLPKQYYTPLKKYHQIEDSVLLIIDSVSNAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQSNKIDDLVVQQKSATIEFSETRSMPASSGLETPVTAKDIIISEEIQNNECVYALSSQDEPIRPLSNLVELMEKEQLKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTRAVLVRRKALSTLAESPILVSEKLPFRNYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGSAMAGSVGGFNAHAANLVTALFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLVQSHMTHNRKTNKANELPQPSNKGPPCKTSALL

Gene Information

Entrez Gene ID
851171
Gene Name
hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
Gene Symbol
HMG2
Species
Saccharomyces cerevisiae S288c

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:SGD C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005635 IDA:SGD C nuclear envelope
GO:0050661 IEA:InterPro F NADP binding
GO:0004420 ISA:SGD F hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0015936 IEA:InterPro P coenzyme A metabolic process
GO:0006696 ISA:SGD P ergosterol biosynthetic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
sce_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
sce00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR025583 HMG-CoA reductase, N-terminal domain
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
hydroxymethylglutaryl-CoA reductase (NADPH) HMG2
Protein Entry
HMDH2_YEAST
UniProt ID
P12684
Species
Yeast (S288c)

Comments

Comment Type Description
Catalytic Activity (R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH. {ECO:0000255|PROSITE- ProRule:PRU10003}.
Function One of 2 isozymes that catalyze the conversion of HMG- CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis. {ECO:0000269|PubMed:3526336}.
Interaction P12683:HMG1; NbExp=3; IntAct=EBI-8384, EBI-8377;
Miscellaneous Present with 149 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
Similarity Belongs to the HMG-CoA reductase family. {ECO:0000305}.
Similarity Contains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.

Identical and Related Proteins

Unique RefSeq proteins for LMP007531 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6323483 RefSeq NP_013555 1045 hydroxymethylglutaryl-CoA reductase (NADPH) HMG2

Identical Sequences to LMP007531 proteins

Reference Database Accession Length Protein Name
GI:6323483 GenBank AAA34677.1 1045 3-hydroxy-3-methyl glutaryl coenzyme A reductase [Saccharomyces cerevisiae]
GI:6323483 GenBank AAB67527.1 1045 Hmg2p: 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [Saccharomyces cerevisiae]
GI:6323483 GenBank AAA94006.1 1045 Sequence 6 from patent US 5460949
GI:6323483 GenBank ABZ27898.1 1045 Sequence 1836 from patent US 7314974
GI:6323483 GenBank EIW09051.1 1045 Hmg2p [Saccharomyces cerevisiae CEN.PK113-7D]
GI:6323483 Third Party Genbank DAA09750.1 1045 TPA: hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 [Saccharomyces cerevisiae S288c]

Related Sequences to LMP007531 proteins

Reference Database Accession Length Protein Name
GI:6323483 DBBJ GAA25304.1 1045 K7_Hmg2p [Saccharomyces cerevisiae Kyokai no. 7]
GI:6323483 GenBank AAT92819.1 1045 YLR450W [Saccharomyces cerevisiae]
GI:6323483 GenBank EDN59347.1 1045 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase isozyme [Saccharomyces cerevisiae YJM789]
GI:6323483 GenBank EWG84645.1 1045 Hmg2p [Saccharomyces cerevisiae R008]
GI:6323483 GenBank EWG94573.1 1045 Hmg2p [Saccharomyces cerevisiae R103]
GI:6323483 GenBank EWH17035.1 1045 Hmg2p [Saccharomyces cerevisiae P283]