Gene/Proteome Database (LMPD)

LMPD ID
LMP007543
Gene ID
945766
Species
Escherichia coli K-12 (E. coli)
Gene Name
malonyl-CoA-[acyl-carrier-protein] transacylase
Gene Symbol
fabD
Synonyms
ECK1078; JW1078; tfpA
Summary
The fabD gene is part of a fatty acid biosynthesis operon and the malonyl-CoA transacylase is part of a multienzyme fatty acid synthase II complex. [More information is available at EcoCyc: EG11317].
Orthologs
View orthologs and multiple alignments for fabD

Proteins

malonyl-CoA-[acyl-carrier-protein] transacylase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_415610
Protein GI 16129055
UniProt ID P0AAI9
Length 309
RefSeq Status REVIEWED
MTQFAFVFPGQGSQTVGMLADMAASYPIVEETFAEASAALGYDLWALTQQGPAEELNKTWQTQPALLTASVALYRVWQQQGGKAPAMMAGHSLGEYSALVCAGVIDFADAVRLVEMRGKFMQEAVPEGTGAMAAIIGLDDASIAKACEEAAEGQVVSPVNFNSPGQVVIAGHKEAVERAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFNAPTVPVVNNVDVKCETNGDAIRDALVRQLYNPVQWTKSVEYMAAQGVEHLYEVGPGKVLTGLTKRIVDTLTASALNEPSAMAAALEL

Gene Information

Entrez Gene ID
945766
Gene Name
malonyl-CoA-[acyl-carrier-protein] transacylase
Gene Symbol
fabD
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004314 IMP:EcoCyc F [acyl-carrier-protein] S-malonyltransferase activity
GO:0006633 IDA:EcoCyc P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00061 Fatty acid biosynthesis
ko00061 Fatty acid biosynthesis
eco_M00082 Fatty acid biosynthesis, initiation
M00082 Fatty acid biosynthesis, initiation
eco01212 Fatty acid metabolism
ko01212 Fatty acid metabolism
eco01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-4381 fatty acid biosynthesis initiation I
PWY-4381 fatty acid biosynthesis initiation I
PWY-4381 fatty acid biosynthesis initiation I
PWY0-881 superpathway of fatty acid biosynthesis I (E. coli)
PWY0-881 superpathway of fatty acid biosynthesis I (E. coli)
FASYN-INITIAL-PWY superpathway of fatty acid biosynthesis initiation (E. coli)
FASYN-INITIAL-PWY superpathway of fatty acid biosynthesis initiation (E. coli)
FASYN-INITIAL-PWY superpathway of fatty acid biosynthesis initiation (E. coli)
PWY-6285 superpathway of fatty acids biosynthesis (E. coli)

Domain Information

InterPro Annotations

Accession Description
IPR014043 Acyl transferase
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR001227 Acyl transferase domain
IPR024925 Malonyl_CoA-ACP_transAc
IPR004410 Malonyl_CoA-ACP_transAc_FabD
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding

UniProt Annotations

Entry Information

Gene Name
malonyl-CoA-[acyl-carrier-protein] transacylase
Protein Entry
FABD_ECOLI
UniProt ID
P0AAI9
Species
E. coli

Comments

Comment Type Description
Catalytic Activity Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the FabD family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007543 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16129055 RefSeq NP_415610 309 malonyl-CoA-[acyl-carrier-protein] transacylase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007543 proteins

Reference Database Accession Length Protein Name
GI:16129055 GenBank KHJ03011.1 309 malonyl CoA-ACP transacylase [Escherichia coli]
GI:16129055 GenBank KHJ05627.1 309 malonyl CoA-ACP transacylase [Escherichia coli]
GI:16129055 GenBank KHJ10640.1 309 malonyl CoA-ACP transacylase [Escherichia coli]
GI:16129055 GenBank KHJ17519.1 309 malonyl CoA-ACP transacylase [Escherichia coli]
GI:16129055 GenBank KHJ22769.1 309 malonyl CoA-ACP transacylase [Escherichia coli]
GI:16129055 gnl IGS 309 malonyl-CoA-[acyl-carrier-protein] transacylase [Escherichia coli ER2796]

Related Sequences to LMP007543 proteins

Reference Database Accession Length Protein Name
GI:16129055 GenBank EII93666.1 309 [acyl-carrier-protein] S-malonyltransferase [Escherichia coli TW07793]
GI:16129055 GenBank KDX43062.1 317 malonyl CoA-acyl carrier protein transacylase [Escherichia coli 2-156-04_S4_C3]
GI:16129055 GenBank KDX61420.1 317 malonyl CoA-acyl carrier protein transacylase [Escherichia coli 2-210-07_S4_C2]
GI:16129055 GenBank KDX69750.1 317 malonyl CoA-acyl carrier protein transacylase [Escherichia coli 2-210-07_S4_C3]
GI:16129055 GenBank KEM92438.1 317 malonyl CoA-acyl carrier protein transacylase [Escherichia coli 2-222-05_S4_C1]
GI:16129055 RefSeq WP_032169893.1 317 malonyl CoA-ACP transacylase [Escherichia coli]