Gene/Proteome Database (LMPD)

LMPD ID
LMP007551
Gene ID
948673
Species
Escherichia coli K-12 (E. coli)
Gene Name
phosphatidylserine decarboxylase
Gene Symbol
psd
Synonyms
ECK4156; JW4121
Summary
N-terminal of alpha subunit (Ser254) is midified to pyruvic acid, a point mutation here results in reduced processing. [More information is available at EcoGene: EG10775]. This subunit contains the pyruvate prosthetic group. [More information is available at EcoCyc: EG10775].
Orthologs
View orthologs and multiple alignments for psd

Proteins

phosphatidylserine decarboxylase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_418584
Protein GI 16131985
UniProt ID P0A8K1
Length 322
RefSeq Status REVIEWED
MLNSFKLSLQYILPKLWLTRLAGWGASKRAGWLTKLVIDLFVKYYKVDMKEAQKPDTASYRTFNEFFVRPLRDEVRPIDTDPNVLVMPADGVISQLGKIEEDKILQAKGHNYSLEALLAGNYLMADLFRNGTFVTTYLSPRDYHRVHMPCNGILREMIYVPGDLFSVNHLTAQNVPNLFARNERVICLFDTEFGPMAQILVGATIVGSIETVWAGTITPPREGIIKRWTWPAGENDGSVALLKGQEMGRFKLGSTVINLFAPGKVNLVEQLESLSVTKIGQPLAVSTETFVTPDAEPAPLPAEEIEAEHDASPLVDDKKDQV

Gene Information

Entrez Gene ID
948673
Gene Name
phosphatidylserine decarboxylase
Gene Symbol
psd
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004609 IDA:EcoCyc F phosphatidylserine decarboxylase activity
GO:0006646 IEA:UniProtKB-UniPathway P phosphatidylethanolamine biosynthetic process
GO:0008654 IDA:EcoCyc P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism
eco01100 Metabolic pathways
M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE
eco_M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE

Domain Information

InterPro Annotations

Accession Description
IPR003817 Phosphatidylserine decarboxylase-related

UniProt Annotations

Entry Information

Gene Name
phosphatidylserine decarboxylase
Protein Entry
PSD_ECOLI
UniProt ID
P0A8K1
Species
E. coli

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 6.5-7.5. {ECO:0000269|PubMed:4598120};
Catalytic Activity Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2). {ECO:0000269|PubMed:4598120}.
Cofactor Name=pyruvoyl group; Xref=ChEBI:CHEBI:45360; Evidence={ECO:0000269|PubMed:3042771};
Enzyme Regulation Inhibited by ionic detergents such as Barlox- 12, an amine oxide, and sodium dodecyl sulfate. {ECO:0000269|PubMed:4598120}.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. {ECO:0000269|PubMed:4598120}.
Ptm Is synthesized initially as an inactive proenzyme, which is activated by cleavage to produce a beta chain and an alpha chain. {ECO:0000269|PubMed:3042771}.
Similarity Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:4598120}; Peripheral membrane protein {ECO:0000269|PubMed:4598120}.
Subunit Multimer of the heterodimer. {ECO:0000269|PubMed:3042771}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007551 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16131985 RefSeq NP_418584 322 phosphatidylserine decarboxylase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007551 proteins

Reference Database Accession Length Protein Name
GI:16131985 GenBank KHJ03877.1 322 phosphatidylserine decarboxylase [Escherichia coli]
GI:16131985 GenBank KHJ08625.1 322 phosphatidylserine decarboxylase [Escherichia coli]
GI:16131985 GenBank KHJ12964.1 322 phosphatidylserine decarboxylase [Escherichia coli]
GI:16131985 GenBank KHJ19488.1 322 phosphatidylserine decarboxylase [Escherichia coli]
GI:16131985 GenBank KHJ28686.1 322 phosphatidylserine decarboxylase [Escherichia coli]
GI:16131985 gnl IGS 322 phosphatidylserine decarboxylase [Escherichia coli ER2796]

Related Sequences to LMP007551 proteins

Reference Database Accession Length Protein Name
GI:16131985 GenBank EGB70597.1 322 phosphatidylserine decarboxylase [Escherichia coli TW10509]
GI:16131985 GenBank EGC06219.1 322 phosphatidylserine decarboxylase [Escherichia fergusonii B253]
GI:16131985 GenBank EHW47533.1 322 phosphatidylserine decarboxylase [Escherichia coli DEC9D]
GI:16131985 GenBank ELG93193.1 322 phosphatidylserine decarboxylase proenzyme [Escherichia coli KTE146]
GI:16131985 RefSeq WP_000934924.1 322 phosphatidylserine decarboxylase [Escherichia coli]
GI:16131985 RefSeq WP_001601303.1 322 phosphatidylserine decarboxylase proenzyme [Escherichia coli]