Gene/Proteome Database (LMPD)

LMPD ID
LMP007559
Gene ID
948907
Species
Escherichia coli K-12 (E. coli)
Gene Name
acyl-CoA thioester hydrolase
Gene Symbol
ybgC
Synonyms
ECK0725; JW0726
Summary
YbgC-ACP interacts with PssA and PlsB. ybgC is the first gene in tolQRA operon. [More information is available at EcoGene: EG11110]. Esterase/thioesterase activity of YbgC was discovered in a high-throughput screen of purified proteins . [More information is available at EcoCyc: EG11110].
Orthologs
View orthologs and multiple alignments for ybgC

Proteins

acyl-CoA thioester hydrolase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_415264
Protein GI 16128711
UniProt ID P0A8Z3
Length 134
RefSeq Status REVIEWED
MNTTLFRWPVRVYYEDTDAGGVVYHASYVAFYERARTEMLRHHHFSQQALMAERVAFVVRKMTVEYYAPARLDDMLEIQTEITSMRGTSLVFTQRIVNAENTLLNEAEVLVVCVDPLKMKPRALPKSIVAEFKQ

Gene Information

Entrez Gene ID
948907
Gene Name
acyl-CoA thioester hydrolase
Gene Symbol
ybgC
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016790 IDA:EcoCyc F thiolester hydrolase activity
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR008272 HB-CoA_thioesterase_AS
IPR029069 HotDog domain
IPR006683 Thioesterase superfamily
IPR014166 Tol-Pal_acyl-CoA_thioesterase
IPR006684 YbgC/YbaW

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioester hydrolase
Protein Entry
YBGC_ECOLI
UniProt ID
P0A8Z3
Species
E. coli

Comments

Comment Type Description
Function Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro, catalyzing the hydrolysis of the thioester bond. {ECO:0000269|PubMed:16294310}.
Interaction P0A6A8:acpP; NbExp=6; IntAct=EBI-543276, EBI-542566; O32591:espP (xeno); NbExp=3; IntAct=EBI-543276, EBI-852989; P0A7A7:plsB; NbExp=3; IntAct=EBI-543276, EBI-542961; P10408:secA; NbExp=3; IntAct=EBI-543276, EBI-543213;
Similarity Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. {ECO:0000305}.
Subcellular Location Cell inner membrane {ECO:0000269|PubMed:16294310}; Peripheral membrane protein {ECO:0000269|PubMed:16294310}; Cytoplasmic side {ECO:0000269|PubMed:16294310}.
Subunit Interacts with ACP, PlsB and PssA, forming altogether a complex at the inner membrane. {ECO:0000269|PubMed:16294310}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007559 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16128711 RefSeq NP_415264 134 acyl-CoA thioester hydrolase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007559 proteins

Reference Database Accession Length Protein Name
GI:16128711 GenBank KHJ09651.1 134 acyl-CoA thioesterase [Escherichia coli]
GI:16128711 GenBank KHJ10449.1 134 acyl-CoA thioesterase [Escherichia coli]
GI:16128711 GenBank KHJ17352.1 134 acyl-CoA thioesterase [Escherichia coli]
GI:16128711 GenBank KHJ20653.1 134 acyl-CoA thioesterase [Escherichia coli]
GI:16128711 GenBank KHJ21599.1 134 acyl-CoA thioesterase [Escherichia coli]
GI:16128711 gnl IGS 134 acyl-CoA thioesterase, involved in phospholipid metabolism [Escherichia coli ER2796]

Related Sequences to LMP007559 proteins

Reference Database Accession Length Protein Name
GI:16128711 PDB 1S5U 138 Chain B, Crystal Structure Of Hypothetical Protein Ec709 From Escherichia Coli
GI:16128711 PDB 1S5U 138 Chain C, Crystal Structure Of Hypothetical Protein Ec709 From Escherichia Coli
GI:16128711 PDB 1S5U 138 Chain D, Crystal Structure Of Hypothetical Protein Ec709 From Escherichia Coli
GI:16128711 PDB 1S5U 138 Chain E, Crystal Structure Of Hypothetical Protein Ec709 From Escherichia Coli
GI:16128711 PDB 1S5U 138 Chain F, Crystal Structure Of Hypothetical Protein Ec709 From Escherichia Coli
GI:16128711 PDB 1S5U 138 Chain G, Crystal Structure Of Hypothetical Protein Ec709 From Escherichia Coli