Gene/Proteome Database (LMPD)

LMPD ID
LMP007571
Gene ID
944849
Species
Escherichia coli K-12 (E. coli)
Gene Name
UDP-N-acetylglucosamine acetyltransferase
Gene Symbol
lpxA
Synonyms
ECK0180; JW0176
Summary
LpxA contains 24 hexapeptide repeats. [More information is available at EcoGene: EG10545]. UDP-N-acetylglucosamine acyltransferase (LpxA) catalyzes the first reaction of lipid A biosynthesis. [More information is available at EcoCyc: EG10545].
Orthologs
View orthologs and multiple alignments for lpxA

Proteins

UDP-N-acetylglucosamine acetyltransferase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_414723
Protein GI 16128174
UniProt ID P0A722
Length 262
RefSeq Status REVIEWED
MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR

Gene Information

Entrez Gene ID
944849
Gene Name
UDP-N-acetylglucosamine acetyltransferase
Gene Symbol
lpxA
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:EcoliWiki C cytoplasm
GO:0008780 IDA:EcoliWiki F acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
GO:0042802 IDA:EcoCyc F identical protein binding
GO:0009245 IEA:UniProtKB-KW P lipid A biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00540 Lipopolysaccharide biosynthesis
ko00540 Lipopolysaccharide biosynthesis
eco_M00060 Lipopolysaccharide biosynthesis, KDO2-lipid A
M00060 Lipopolysaccharide biosynthesis, KDO2-lipid A
eco01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
NAGLIPASYN-PWY lipid IVA biosynthesis
NAGLIPASYN-PWY lipid IVA biosynthesis
NAGLIPASYN-PWY lipid IVA biosynthesis
KDO-NAGLIPASYN-PWY superpathway of (KDO)2-lipid A biosynthesis
KDO-NAGLIPASYN-PWY superpathway of (KDO)2-lipid A biosynthesis
LPSSYN-PWY superpathway of lipopolysaccharide biosynthesis
LPSSYN-PWY superpathway of lipopolysaccharide biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001451 Bacterial transferase hexapeptide repeat
IPR018357 Hexapeptide transferase, conserved site
IPR010137 Lipid_A_LpxA
IPR011004 Trimeric LpxA-like
IPR029098 Udp N-acetylglucosamine O-acyltransferase, C-terminal

UniProt Annotations

Entry Information

Gene Name
UDP-N-acetylglucosamine acetyltransferase
Protein Entry
LPXA_ECOLI
UniProt ID
P0A722
Species
E. coli

Comments

Comment Type Description
Catalytic Activity (R)-3-hydroxytetradecanoyl-[acyl-carrier- protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier- protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D- glucosamine. {ECO:0000255|HAMAP-Rule:MF_00387}.
Function Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Pathway Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. {ECO:0000255|HAMAP- Rule:MF_00387}.
Similarity Belongs to the transferase hexapeptide repeat family. LpxA subfamily. {ECO:0000255|HAMAP-Rule:MF_00387}.
Subcellular Location Cytoplasm.
Subunit Homotrimer. {ECO:0000255|HAMAP-Rule:MF_00387, ECO:0000269|PubMed:16835299, ECO:0000269|PubMed:17434525, ECO:0000269|PubMed:17698807}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007571 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16128174 RefSeq NP_414723 262 UDP-N-acetylglucosamine acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007571 proteins

Reference Database Accession Length Protein Name
GI:16128174 GenBank KHI93288.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]
GI:16128174 GenBank KHI95636.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]
GI:16128174 GenBank KHJ05944.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]
GI:16128174 GenBank KHJ07582.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]
GI:16128174 GenBank KHJ15472.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]
GI:16128174 gnl IGS 262 UDP-N-acetylglucosamine acetyltransferase [Escherichia coli ER2796]

Related Sequences to LMP007571 proteins

Reference Database Accession Length Protein Name
GI:16128174 EMBL CBG33011.1 262 acyl-[acyl-carrier-protein]--UDP-N-acetylglucos am ine O-acyltransferase [Escherichia coli 042]
GI:16128174 GenBank EZJ90743.1 262 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase [Escherichia coli 1-250-04_S3_C1]
GI:16128174 GenBank KEO39456.1 262 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase [Escherichia coli 1-250-04_S3_C2]
GI:16128174 PDB 2JF2 264 Chain A, Nucleotide Substrate Binding By Udp-n-acetylglucosamine Acyltransferase
GI:16128174 RefSeq WP_000565972.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]
GI:16128174 RefSeq WP_032280282.1 262 UDP-N-acetylglucosamine acyltransferase [Escherichia coli]