Gene/Proteome Database (LMPD)

LMPD ID
LMP007602
Gene ID
945530
Species
Escherichia coli K-12 (E. coli)
Gene Name
lipid ABC transporter permease/ATPase
Gene Symbol
msbA
Synonyms
ECK0905; JW0897
Summary
MsbA PDB structures 1JSQ, 1PF4 and 1Z2R, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Chang, 2006). [More information is available at EcoGene: EG10613]. Lipid A serves as a hydrophobic membrane anchor for the lipopolysaccharide, which is a major component of the outer leaflet of the outer membranes of Gram-negative bacteria. [More information is available at EcoCyc: EG10613].
Orthologs
View orthologs and multiple alignments for msbA

Proteins

lipid ABC transporter permease/ATPase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_415434
Protein GI 16128881
UniProt ID P60752
Length 582
RefSeq Status REVIEWED
MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ

Gene Information

Entrez Gene ID
945530
Gene Name
lipid ABC transporter permease/ATPase
Gene Symbol
msbA
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043190 IEA:UniProtKB-HAMAP C ATP-binding cassette (ABC) transporter complex
GO:0016020 IDA:UniProtKB C membrane
GO:0005524 IDA:EcoCyc F ATP binding
GO:0008144 IDA:EcoliWiki F drug binding
GO:0008289 IDA:EcoliWiki F lipid binding
GO:0005319 IMP:EcoCyc F lipid transporter activity
GO:0034040 IDA:EcoliWiki F lipid-transporting ATPase activity
GO:0015437 IDA:EcoCyc F lipopolysaccharide-transporting ATPase activity
GO:1901264 IDA:GOC P carbohydrate derivative transport
GO:0006869 IMP:EcoCyc P lipid transport

KEGG Pathway Links

KEGG Pathway ID Description
eco02010 ABC transporters
ko02010 ABC transporters

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR011917 ABC_transpr_lipidA
IPR001140 ABC_transptr_TM_dom
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
lipid ABC transporter permease/ATPase
Protein Entry
MSBA_ECOLI
UniProt ID
P60752
Species
E. coli

Comments

Comment Type Description
Domain In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Function Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Similarity Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. {ECO:0000255|HAMAP-Rule:MF_01703}.
Similarity Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|HAMAP-Rule:MF_01703}.
Similarity Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule:MF_01703}.
Subcellular Location Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_01703, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:8809774}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:8809774}.
Subunit Homodimer. {ECO:0000255|HAMAP-Rule:MF_01703}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007602 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16128881 RefSeq NP_415434 582 lipid ABC transporter permease/ATPase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007602 proteins

Reference Database Accession Length Protein Name
GI:16128881 GenBank KHJ03639.1 582 lipid transporter ATP-binding/permease [Escherichia coli]
GI:16128881 GenBank KHJ08870.1 582 lipid transporter ATP-binding/permease [Escherichia coli]
GI:16128881 GenBank KHJ19648.1 582 lipid transporter ATP-binding/permease [Escherichia coli]
GI:16128881 GenBank KHJ25168.1 582 lipid transporter ATP-binding/permease [Escherichia coli]
GI:16128881 GenBank KHJ29009.1 582 lipid transporter ATP-binding/permease [Escherichia coli]
GI:16128881 gnl IGS 582 fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component [Escherichia coli ER2796]

Related Sequences to LMP007602 proteins

Reference Database Accession Length Protein Name
GI:16128881 GenBank ELC10906.1 582 lipid A export ATP-binding/permease MsbA [Escherichia coli KTE10]
GI:16128881 GenBank ESE07359.1 582 lipid A export permease/ATP-binding protein MsbA [Escherichia coli 908658]
GI:16128881 GenBank ESK11365.1 582 lipid A export ATP-binding/permease MsbA [Escherichia coli HVH 50 (4-2593475)]
GI:16128881 GenBank EZE91686.1 582 lipid transporter ATP-binding/permease [Escherichia coli O145:NM str. 2010C-3508]
GI:16128881 RefSeq WP_001515137.1 582 lipid A export ATP-binding/permease MsbA [Escherichia coli]
GI:16128881 RefSeq WP_023149757.1 582 lipid A export permease/ATP-binding protein MsbA [Escherichia coli]