Gene/Proteome Database (LMPD)

LMPD ID
LMP007616
Gene ID
948652
Species
Escherichia coli K-12 (E. coli)
Gene Name
fatty acid metabolism regulon transcriptional regulator
Gene Symbol
fadR
Synonyms
ECK1175; JW1176; dec; ole; oleR; thdB
Summary
The fad genes are induced and fabAB, iclR are repressed by long chain acyl-CoA thioesters binding to and releasing FadR from the DNA. [More information is available at EcoGene: EG10281]. FadR is a dual DNA-binding transcriptional regulator for fatty acid metabolism. [More information is available at EcoCyc: EG10281].
Orthologs
View orthologs and multiple alignments for fadR

Proteins

fatty acid metabolism regulon transcriptional regulator [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_415705
Protein GI 16129150
UniProt ID P0A8V6
Length 239
RefSeq Status REVIEWED
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR

Gene Information

Entrez Gene ID
948652
Gene Name
fatty acid metabolism regulon transcriptional regulator
Gene Symbol
fadR
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-HAMAP C cytoplasm
GO:0003677 IEA:UniProtKB-HAMAP F DNA binding
GO:0000062 IEA:InterPro F fatty-acyl-CoA binding
GO:0003700 ISS:EcoCyc F sequence-specific DNA binding transcription factor activity
GO:0019395 EXP:EcoCyc P fatty acid oxidation
GO:0045892 ISS:EcoCyc P negative regulation of transcription, DNA-templated
GO:0045723 IMP:CACAO P positive regulation of fatty acid biosynthetic process
GO:0045893 ISS:EcoCyc P positive regulation of transcription, DNA-templated
GO:0019217 IGI:CACAO P regulation of fatty acid metabolic process
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR028374 FadR_C
IPR014178 FA-response_TF_FadR
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR011991 Winged helix-turn-helix DNA-binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acid metabolism regulon transcriptional regulator
Protein Entry
FADR_ECOLI
UniProt ID
P0A8V6
Species
E. coli

Comments

Comment Type Description
Domain The C-terminal domain bind acyl-CoA.
Function Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. Binding of FadR is specifically inhibited by long chain fatty acyl-CoA compounds.
Similarity Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule:MF_00696}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00696}.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP007616 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16129150 RefSeq NP_415705 239 fatty acid metabolism regulon transcriptional regulator [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007616 proteins

Reference Database Accession Length Protein Name
GI:16129150 GenBank KHJ06629.1 239 fatty acid metabolism regulator [Escherichia coli]
GI:16129150 GenBank KHJ13630.1 239 fatty acid metabolism regulator [Escherichia coli]
GI:16129150 GenBank KHJ16076.1 239 fatty acid metabolism regulator [Escherichia coli]
GI:16129150 GenBank KHJ27345.1 239 fatty acid metabolism regulator [Escherichia coli]
GI:16129150 GenBank KHJ28756.1 239 fatty acid metabolism regulator [Escherichia coli]
GI:16129150 gnl IGS 239 DNA-binding transcriptional dual regulator of fatty acid metabolism [Escherichia coli ER2796]

Related Sequences to LMP007616 proteins

Reference Database Accession Length Protein Name
GI:16129150 GenBank EGJ05323.1 247 fatty acid metabolism transcriptional regulator FadR [Escherichia coli D9]
GI:16129150 gnl mgcchina 247 fatty acid metabolism regulator [Shigella flexneri 5 str. 8401]
GI:16129150 gnl REF_mgcchina 247 fatty acid metabolism regulator [Shigella flexneri 5 str. 8401]
GI:16129150 gnl ChinaCDC 247 Fatty acid metabolism regulator protein [Shigella flexneri 2002017]
GI:16129150 RefSeq YP_005726877.1 247 Fatty acid metabolism regulator protein [Shigella flexneri 2002017]
GI:16129150 RefSeq WP_000882869.1 247 fatty acid metabolism regulator [Shigella flexneri]