Gene/Proteome Database (LMPD)

LMPD ID
LMP007626
Gene ID
947955
Species
Escherichia coli K-12 (E. coli)
Gene Name
glycerophosphodiester phosphodiesterase, cytosolic
Gene Symbol
ugpQ
Synonyms
ECK3433; JW3414
Summary
Pho regulon. [More information is available at EcoGene: EG11050]. UgpQ is a cytosolic glycerophosphodiester phosphodiesterase with broad substrate specificity . [More information is available at EcoCyc: EG11050].
Orthologs
View orthologs and multiple alignments for ugpQ

Proteins

glycerophosphodiester phosphodiesterase, cytosolic [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417906
Protein GI 16131321
UniProt ID P10908
Length 247
RefSeq Status REVIEWED
MSNWPYPRIVAHRGGGKLAPENTLASIDVGAKYGHKMIEFDAKLSKDGEIFLLHDDNLERTSNGWGVAGELNWQDLLRVDAGSWYSKMFKGEPLPLLSQVAERCREHGMMANIEIKPTTGTGPLTGKMVALAARELWAGMTPPLLSSFEIDALEAAQQAAPELPRGLLLDEWRDDWRELTARLGCVSIHLNHKLLNKARVMQLKDAGLRILVYTVNKPQRAAELLRWGVDCICTDAIDVIGPNFTAQ

Gene Information

Entrez Gene ID
947955
Gene Name
glycerophosphodiester phosphodiesterase, cytosolic
Gene Symbol
ugpQ
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0047389 IDA:EcoCyc F glycerophosphocholine phosphodiesterase activity
GO:0008889 IDA:EcoCyc F glycerophosphodiester phosphodiesterase activity
GO:0047395 IDA:EcoCyc F glycerophosphoinositol glycerophosphodiesterase activity
GO:0000287 IDA:EcoCyc F magnesium ion binding
GO:0006071 IEA:UniProtKB-KW P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-381 glycerol and glycerophosphodiester degradation
PWY0-381 glycerol and glycerophosphodiester degradation
PWY0-381 glycerol degradation I
PWY-6952 glycerophosphodiester degradation
PWY-6952 glycerophosphodiester degradation

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase, cytosolic
Protein Entry
UGPQ_ECOLI
UniProt ID
P10908
Species
E. coli

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.22 mM for glycerophosphoethanolamine {ECO:0000269|PubMed:18083802}; KM=0.66 mM for glycerophosphoserine {ECO:0000269|PubMed:18083802}; KM=0.62 mM for glycerophosphoglycerol {ECO:0000269|PubMed:18083802}; KM=0.39 mM for glycerophosphoinositol {ECO:0000269|PubMed:18083802}; KM=2.0 mM for glycerophosphocholine {ECO:0000269|PubMed:18083802}; pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:18083802};
Catalytic Activity A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. {ECO:0000269|PubMed:18083802}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:18083802}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:18083802}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:18083802};
Function Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
Induction Up-regulated by low levels of phosphate in the medium. {ECO:0000269|PubMed:18083802}.
Miscellaneous There are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli: a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ).
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
Similarity Contains 1 GP-PDE domain. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18083802}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007626 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16131321 RefSeq NP_417906 247 glycerophosphodiester phosphodiesterase, cytosolic [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007626 proteins

Reference Database Accession Length Protein Name
GI:16131321 EMBL CEE09650.1 247 glycerophosphoryl diester phosphodiesterase [Escherichia coli]
GI:16131321 EMBL CDY63446.1 247 glycerophosphodiester phosphodiesterase, cytosolic [Escherichia coli]
GI:16131321 EMBL CDZ22223.1 247 glycerophosphodiester phosphodiesterase, cytosolic [Escherichia coli]
GI:16131321 GenBank KGL68547.1 247 cytoplasmic glycerophosphodiester phosphodiesterase [Escherichia coli NCTC 50110]
GI:16131321 gnl PRJNA257976 247 glycerophosphodiester phosphodiesterase, cytosolic [Escherichia coli BW25113]
GI:16131321 gnl IGS 247 glycerophosphodiester phosphodiesterase, cytosolic [Escherichia coli ER2796]

Related Sequences to LMP007626 proteins

Reference Database Accession Length Protein Name