Gene/Proteome Database (LMPD)

LMPD ID
LMP007627
Gene ID
947732
Species
Escherichia coli K-12 (E. coli)
Gene Name
ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein
Gene Symbol
mlaE
Synonyms
ECK3183; JW3161; vpsB; yrbE
Summary
YrbE is in an operon with ABC transporter homologs and may be a permease protein. [More information is available at EcoGene: EG12800]. Yrbe is the membrane component of a predicted ABC superfamily toluene efflux transporter. [More information is available at EcoCyc: EG12800].
Orthologs
View orthologs and multiple alignments for mlaE

Proteins

ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417661
Protein GI 16131084
UniProt ID P64606
Length 260
RefSeq Status REVIEWED
MLLNALASLGHKGIKTLRTFGRAGLMLFNALVGKPEFRKHAPLLVRQLYNVGVLSMLIIVVSGVFIGMVLGLQGYLVLTTYSAETSLGMLVALSLLRELGPVVAALLFAGRAGSALTAEIGLMRATEQLSSMEMMAVDPLRRVISPRFWAGVISLPLLTVIFVAVGIWGGSLVGVSWKGIDSGFFWSAMQNAVDWRMDLVNCLIKSVVFAITVTWISLFNGYDAIPTSAGISRATTRTVVHSSLAVLGLDFVLTALMFGN

Gene Information

Entrez Gene ID
947732
Gene Name
ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein
Gene Symbol
mlaE
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005543 IMP:EcoCyc F phospholipid binding
GO:0005548 IMP:EcoCyc F phospholipid transporter activity
GO:0015914 IMP:GOC P phospholipid transport

KEGG Pathway Links

KEGG Pathway ID Description
eco02010 ABC transporters
ko02010 ABC transporters
M00210 Phospholipid transport system
eco_M00210 Phospholipid transport system

Domain Information

InterPro Annotations

Accession Description
IPR003453 Permease domain

UniProt Annotations

Entry Information

Gene Name
ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein
Protein Entry
MLAE_ECOLI
UniProt ID
P64606
Species
E. coli

Comments

Comment Type Description
Disruption Phenotype Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed:19383799}.
Function Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO:0000269|PubMed:19383799}.
Similarity Belongs to the MlaE permease family. {ECO:0000305}.
Subcellular Location Cell inner membrane {ECO:0000269|PubMed:19383799}; Multi-pass membrane protein {ECO:0000269|PubMed:19383799}.
Subunit The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed:19383799}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007627 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16131084 RefSeq NP_417661 260 ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007627 proteins

Reference Database Accession Length Protein Name
GI:16131084 GenBank KHJ07263.1 260 ABC transporter permease [Escherichia coli]
GI:16131084 GenBank KHJ13773.1 260 ABC transporter permease [Escherichia coli]
GI:16131084 GenBank KHJ16504.1 260 ABC transporter permease [Escherichia coli]
GI:16131084 GenBank KHJ25762.1 260 ABC transporter permease [Escherichia coli]
GI:16131084 GenBank KHJ26164.1 260 ABC transporter permease [Escherichia coli]
GI:16131084 gnl IGS 260 ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein [Escherichia coli ER2796]

Related Sequences to LMP007627 proteins

Reference Database Accession Length Protein Name
GI:16131084 DBBJ GAL52154.1 260 putative phospholipid ABC transporter permease protein MlaE [Escherichia albertii NBRC 107761]
GI:16131084 GenBank ELC16256.1 260 toluene ABC transporter membrane protein [Escherichia sp. KTE11]
GI:16131084 GenBank EOQ54981.1 260 toluene ABC transporter membrane protein [Escherichia coli KTE33]
GI:16131084 GenBank KHI36704.1 260 ABC transporter permease [Escherichia coli]
GI:16131084 gnl mgcchina 260 conserved hypothetical protein [Shigella dysenteriae Sd197]
GI:16131084 RefSeq WP_000925792.1 260 MULTISPECIES: ABC transporter permease [Enterobacteriaceae]