Gene/Proteome Database (LMPD)
LMPD ID
LMP007682
Gene ID
Species
Escherichia coli K-12 (E. coli)
Gene Name
1-acyl-sn-glycerol-3-phosphate acyltransferase
Gene Symbol
Synonyms
ECK3009; JW2986; parF
Summary
None
Orthologs
Proteins
| 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli str. K-12 substr. MG1655] | |
|---|---|
| Refseq ID | NP_417490 |
| Protein GI | 16130914 |
| UniProt ID | P26647 |
| Length | 245 |
| RefSeq Status | REVIEWED |
| MLYIFRLIITVIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPTDAESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREAAGKV | |
Gene Information
Entrez Gene ID
Gene Name
1-acyl-sn-glycerol-3-phosphate acyltransferase
Gene Symbol
Species
Escherichia coli K-12
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005886 | IDA:EcoCyc | C | plasma membrane |
| GO:0003841 | IMP:EcoCyc | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0016024 | IEA:UniProtKB-UniPathway | P | CDP-diacylglycerol biosynthetic process |
| GO:0046474 | IMP:EcoCyc | P | glycerophospholipid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| eco00561 | Glycerolipid metabolism |
| ko00561 | Glycerolipid metabolism |
| eco00564 | Glycerophospholipid metabolism |
| ko00564 | Glycerophospholipid metabolism |
| eco01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-5667 | CDP-diacylglycerol biosynthesis I |
| PWY-5667 | CDP-diacylglycerol biosynthesis I |
| PWY-5667 | CDP-diacylglycerol biosynthesis I |
| PWY0-1319 | CDP-diacylglycerol biosynthesis II |
| PWY0-1319 | CDP-diacylglycerol biosynthesis II |
| PWY0-1319 | CDP-diacylglycerol biosynthesis II |
| PWY4FS-8 | phosphatidylglycerol biosynthesis II (non-plastidic) |
| PWY4FS-7 | phosphatidylglycerol biosynthesis I (plastidic) |
| PHOSLIPSYN-PWY | phospholipid biosynthesis I |
| PHOSLIPSYN-PWY | phospholipid biosynthesis I |
| PHOSLIPSYN-PWY | phospholipid biosynthesis I |
Domain Information
UniProt Annotations
Entry Information
Gene Name
1-acyl-sn-glycerol-3-phosphate acyltransferase
Protein Entry
PLSC_ECOLI
UniProt ID
Species
E. coli
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-[acyl-carrier-protein] + 1-acyl-sn- glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn- glycerol 3-phosphate. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}. |
| Function | Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. {ECO:0000269|PubMed:2211622}. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}. |
| Subcellular Location | Cell inner membrane {ECO:0000269|PubMed:1557036}; Peripheral membrane protein {ECO:0000269|PubMed:1557036}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007682 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16130914 | RefSeq | NP_417490 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli str. K-12 substr. MG1655] |
Identical Sequences to LMP007682 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130914 | GenBank | KHH97229.1 | 245 | acyl-phosphate glycerol 3-phosphate acyltransferase [Escherichia coli] |
| GI:16130914 | GenBank | KHI12944.1 | 245 | acyl-phosphate glycerol 3-phosphate acyltransferase [Escherichia coli] |
| GI:16130914 | GenBank | KHI21760.1 | 245 | acyl-phosphate glycerol 3-phosphate acyltransferase [Escherichia coli] |
| GI:16130914 | GenBank | KHI59579.1 | 245 | acyl-phosphate glycerol 3-phosphate acyltransferase [Escherichia coli] |
| GI:16130914 | GenBank | KHI85760.1 | 245 | acyl-phosphate glycerol 3-phosphate acyltransferase [Escherichia coli] |
| GI:16130914 | gnl | IGS | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli ER2796] |
Related Sequences to LMP007682 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130914 | DBBJ | BAB37325.1 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli O157:H7 str. Sakai] |
| GI:16130914 | GenBank | ETX79773.1 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli BIDMC 43b] |
| GI:16130914 | GenBank | ETX84198.1 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli BIDMC 43a] |
| GI:16130914 | GenBank | ETX98947.1 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli BIDMC 19B] |
| GI:16130914 | RefSeq | NP_289595.1 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli O157:H7 str. EDL933] |
| GI:16130914 | RefSeq | NP_311929.1 | 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferase [Escherichia coli O157:H7 str. Sakai] |