Gene/Proteome Database (LMPD)

LMPD ID
LMP007715
Gene ID
947934
Species
Escherichia coli K-12 (E. coli)
Gene Name
sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding
Gene Symbol
glpD
Synonyms
ECK3412; JW3389; glyD
Summary
LpxB and GlpD associate in vitro. [More information is available at EcoGene: EG10394]. The aerobic glycerol 3-phosphate dehydrogenase (GlpD) is a homodimeric enzyme associated with the cytoplasmic membrane through binding to negatively-charged phopholipids . [More information is available at EcoCyc: EG10394].
Orthologs
View orthologs and multiple alignments for glpD

Proteins

sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417884
Protein GI 16131300
UniProt ID P13035
Length 501
RefSeq Status REVIEWED
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARRENGLWIVEAEDIDTGKKYSWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLNVYNTHFKKQLSRDDIVWTYSGVRPLCDDESDSPQAITRDYTLDIHDENGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYARTYGSNSELLLGNAGTVSDLGEDFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNADQQSRVSQWLVEYTQQRLSLAS

Gene Information

Entrez Gene ID
947934
Gene Name
sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding
Gene Symbol
glpD
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009331 IDA:EcoCyc C glycerol-3-phosphate dehydrogenase complex
GO:0005887 IDA:EcoCyc C integral component of plasma membrane
GO:0009055 IDA:EcoCyc F electron carrier activity
GO:0052591 IEA:UniProtKB-EC F sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
GO:0052590 IDA:EcoCyc F sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
GO:0046168 IMP:EcoCyc P glycerol-3-phosphate catabolic process
GO:0019563 IEA:UniProtKB-UniPathway P glycerol catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-381 glycerol and glycerophosphodiester degradation
PWY0-381 glycerol and glycerophosphodiester degradation
PWY-4261 glycerol degradation I
PWY0-381 glycerol degradation I
PWY-4261 glycerol degradation I
PWY-6952 glycerophosphodiester degradation
PWY-6952 glycerophosphodiester degradation

Domain Information

InterPro Annotations

Accession Description
IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase
IPR006076 FAD dependent oxidoreductase

UniProt Annotations

Entry Information

Gene Name
sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding
Protein Entry
GLPD_ECOLI
UniProt ID
P13035
Species
E. coli

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor.
Interaction P0ACS9:acrR; NbExp=1; IntAct=EBI-548509, EBI-1117360; P69330:citD; NbExp=1; IntAct=EBI-548509, EBI-1119230; P0A9K7:phoU; NbExp=1; IntAct=EBI-548509, EBI-1133614; P0A8D3:yaiI; NbExp=1; IntAct=EBI-548509, EBI-1116378;
Miscellaneous There are two sn-glycerol-3-phosphate dehydrogenase isozymes in E.coli: one is aerobic, the other anaerobic.
Pathway Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1.
Sequence Caution Sequence=AAA23888.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP007715 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16131300 RefSeq NP_417884 501 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007715 proteins

Reference Database Accession Length Protein Name
GI:16131300 GenBank KHH88541.1 501 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131300 GenBank KHH91823.1 501 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131300 GenBank KHI18724.1 501 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131300 GenBank KHI19124.1 501 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131300 GenBank KHI60312.1 501 glycerol-3-phosphate dehydrogenase [Escherichia coli]
GI:16131300 gnl IGS 501 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding [Escherichia coli ER2796]

Related Sequences to LMP007715 proteins

Reference Database Accession Length Protein Name
GI:16131300 GenBank EGI08646.1 506 glycerol-3-phosphate dehydrogenase [Escherichia coli H736]
GI:16131300 GenBank EQQ18660.1 501 aerobic glycerol-3-phosphate dehydrogenase [Escherichia coli HVH 91 (4-4638751)]
GI:16131300 GenBank EQZ62488.1 501 aerobic glycerol-3-phosphate dehydrogenase [Escherichia coli UMEA 3682-1]
GI:16131300 GenBank ERA98486.1 501 aerobic glycerol-3-phosphate dehydrogenase [Escherichia coli KOEGE 3 (4a)]
GI:16131300 RefSeq YP_006135875.1 501 aerobic glycerol-3-phosphate dehydrogenase [Escherichia coli UMNK88]
GI:16131300 RefSeq YP_006170516.1 501 glycerol-3-phosphate dehydrogenase [Escherichia coli P12b]