Gene/Proteome Database (LMPD)

LMPD ID
LMP007729
Gene ID
947408
Species
Escherichia coli K-12 (E. coli)
Gene Name
methylmalonyl-CoA decarboxylase, biotin-independent
Gene Symbol
scpB
Synonyms
ECK2915; JW2886; mmcD; ygfG
Summary
Part of a four gene operon encoding enzymes converting succinate to propionate. [More information is available at EcoGene: EG12972]. Methylmalonyl-CoA decarboxylase is a biotin-independent enzyme that catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. [More information is available at EcoCyc: G7516].
Orthologs
View orthologs and multiple alignments for scpB

Proteins

methylmalonyl-CoA decarboxylase, biotin-independent [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417394
Protein GI 90111512
UniProt ID P52045
Length 261
RefSeq Status REVIEWED
MSYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNHVVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSEDYQEGMNAFLEKRKPNFVGH

Gene Information

Entrez Gene ID
947408
Gene Name
methylmalonyl-CoA decarboxylase, biotin-independent
Gene Symbol
scpB
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0016831 ISS:UniProtKB F carboxy-lyase activity
GO:0004492 IDA:EcoCyc F methylmalonyl-CoA decarboxylase activity

KEGG Pathway Links

KEGG Pathway ID Description
eco00640 Propanoate metabolism
ko00640 Propanoate metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-43 conversion of succinate to propionate
PWY0-43 conversion of succinate to propionate
PWY0-43 conversion of succinate to propionate

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR014748 Crontonase, C-terminal
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
methylmalonyl-CoA decarboxylase, biotin-independent
Protein Entry
SCPB_ECOLI
UniProt ID
P52045
Species
E. coli

Comments

Comment Type Description
Catalytic Activity (S)-methylmalonyl-CoA = propanoyl-CoA + CO(2). {ECO:0000269|PubMed:10769117}.
Function Catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propionate. {ECO:0000269|PubMed:10769117}.
Sequence Caution Sequence=AAA69086.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subunit Dimer of homotrimers. {ECO:0000269|PubMed:10769118}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007729 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90111512 RefSeq NP_417394 261 methylmalonyl-CoA decarboxylase, biotin-independent [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007729 proteins

Reference Database Accession Length Protein Name
GI:90111512 GenBank KHI97103.1 261 methylmalonyl-CoA decarboxylase [Escherichia coli]
GI:90111512 GenBank KHJ09192.1 261 methylmalonyl-CoA decarboxylase [Escherichia coli]
GI:90111512 GenBank KHJ12478.1 261 methylmalonyl-CoA decarboxylase [Escherichia coli]
GI:90111512 GenBank KHJ21140.1 261 methylmalonyl-CoA decarboxylase [Escherichia coli]
GI:90111512 GenBank KHJ29572.1 261 methylmalonyl-CoA decarboxylase [Escherichia coli]
GI:90111512 gnl IGS 261 methylmalonyl-CoA decarboxylase, biotin-independent [Escherichia coli ER2796]

Related Sequences to LMP007729 proteins

Reference Database Accession Length Protein Name
GI:90111512 EMBL CCK48204.1 275 putative enzyme [Escherichia coli chi7122]
GI:90111512 GenBank EGI09306.1 275 methylmalonyl-CoA decarboxylase (Transcarboxylase)(MMCD) [Escherichia coli H736]
GI:90111512 GenBank EGI39893.1 275 methylmalonyl-CoA decarboxylase (Transcarboxylase)(MMCD) [Escherichia coli TA280]
GI:90111512 GenBank EGI45057.1 275 methylmalonyl-CoA decarboxylase (Transcarboxylase)(MMCD) [Escherichia coli H591]
GI:90111512 GenBank EGJ06091.1 275 enoyl-CoA hydratase/isomerase family protein [Escherichia coli D9]
GI:90111512 RefSeq WP_001311113.1 275 methylmalonyl-CoA decarboxylase [Escherichia coli]